Risk for Gestational Diabetes: A Condition of Abdominal Fatness or Sedentariness?

妊娠期糖尿病的风险：腹部肥胖或久坐的情况？

• 批准号: 10047149
• 负责人: Katherine Heimburger Ingram
• 金额: $ 40.63万
• 依托单位: KENNESAW STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10047149
• 关键词: Abdomen; Accelerometer; Adipose tissue; Affect; Age; Beta Cell; Body Composition; Body fat; C-Peptide; Central obesity; Child; Childhood; Childhood diabetes; Computer Models; Dangerousness; Data Collection; Development; Early Intervention; Equipment; Exercise; Exercise Test; Exposure to; Future; Gases; Gestational Diabetes; Health; High-Risk Pregnancy; Hour; Intra-abdominal; Laboratories; Life Style; Measures; Metabolic Diseases; Methods; Modeling; Neonatal; Non-Insulin-Dependent Diabetes Mellitus; Nulliparity; OGTT; Obesity; Overweight; Physiology; Plasma; Population; Population Intervention; Postpartum Period; Pregnancy; Pregnant Women; Prospective cohort study; Race; Recording of previous events; Regression Analysis; Research; Research Assistant; Risk; Risk Factors; Role; Sampling; Science; Structure of beta Cell of islet; Students; Testing; Thick; Third Pregnancy Trimester; Time; Ultrasonography; Universities; Visit; abdominal fat; cardiorespiratory fitness; college; diabetes risk; early pregnancy; effective intervention; experience; fitness; gestational weight gain; high risk; insight; insulin sensitivity; lifestyle intervention; maternal obesity; novel; obesity in children; prenatal; racial diversity; sedentary; sedentary activity; sedentary lifestyle; skills; subcutaneous; undergraduate research

Intrauterine exposure to gestational diabetes (GDM) is associated with a high risk of childhood obesity and explains over 47% of pediatric type 2 diabetes. To mitigate this impact of GDM on children, high-risk pregnancies must be identified earlier and effective interventions must be developed. Maternal obesity, and especially central obesity, is a known predictor of GDM and research shows that exercise is protective. What remains unknown are the roles of sedentariness and cardiorespiratory fitness (CRF) within the obesity-GDM relationship. The purpose of the proposed study is to determine the independent and interaction effects among ultrasound measures of abdominal adiposity, sedentariness, and CRF on insulin sensitivity and pancreatic β-cell responsivity in pregnancy. Once these relationships are delineated, then effective lifestyle interventions can be developed. This is a prospective cohort study of 115 racially diverse, nulliparous pregnant women,18-35 years old, and overweight or obese (BMI 25-35) with no history of metabolic disease. Measures will include body composition, including ultrasound assessment of abdominal adipose tissue as intra-abdominal and subcutaneous, sedentary behavior via 4-day accelerometry, minimal model computation of insulin sensitivity and pancreatic β-cell responsivity from 2-hour frequently sampled oral glucose tolerance test, and CRF via graded exercise test. Four visits will take place in the Kennesaw State University Exercise Science (ES) Physiology Laboratory at baseline (12-15 weeks), mid-gestation (18-19 weeks), third trimester (26-28 weeks), and post-partum (4 weeks). Independent and interaction effects of abdominal adipose tissue thickness, sedentary behavior, and CRF on gestational insulin sensitivity and pancreatic β-cell responsivity will be tested.

宫内暴露于妊娠期糖尿病（GDM）与儿童肥胖的高风险相关，并解释了超过47%的儿童2型糖尿病。为了减轻GDM对儿童的影响，必须及早发现高危妊娠，并制定有效的干预措施。母亲肥胖，尤其是中心性肥胖，是已知的GDM的预测因子，研究表明运动是有保护作用的。目前尚不清楚的是久坐的作用