Intensive Combination Approach to Rollback the Epidemic (iCARE) in Nigerian Adolescents
Intensive Combination Approach to Rollback the Epidemic (iCARE) in Nigerian Adolescents
批准号:
10046115
负责人:
Robert Garofalo
金额:
$37.64万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-01-17 至 2020-08-31
关键词:
AIDS/HIV problemAdolescentAdultAfrica South of the SaharaAgeAwarenessBloodCaringCenters for Disease Control and Prevention (U.S.)ClinicCollaborationsCommunitiesContinuity of Patient CareDevelopmentEpidemicEvidence based interventionFeedbackFocus GroupsGenderGoalsGovernmentHIVHIV InfectionsHIV SeroprevalenceHairHealthHot SpotHuman immunodeficiency virus testIncidenceInfrastructureInstitutionInterventionLinkLiteratureMeasurementMeasuresMediator of activation proteinMedical RecordsNigeriaNigerianOutcomeOutcome MeasurePharmacy facilityPhasePoliciesPopulationPovertyPrevalencePublic HealthRandomizedRecordsResearchResearch TrainingSiteSubgroupTestingText MessagingTimeUnited States National Institutes of HealthUniversitiesViralViral Load resultYouthagedantiretroviral therapybaseburden of illnesscare outcomesdesignevidence baseexperienceimprovedinnovationintervention effectmHealthmedication compliancemen who have sex with menmultidisciplinaryneglectpediatric human immunodeficiency virus infectionpeerpilot trialprimary outcomeprogramsresponsesame-sex partnershipsocial mediasocial stigmatherapy adherencetherapy developmenttransmission processworking groupyoung manyoung men who have sex with men
中文摘要
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英文摘要
Nigeria has the 2nd highest number of people living with HIV (PLWH) and the most pediatric HIV infections
globally, however, it has been neglected as a focus of public health efforts. Progress towards UNAIDS 90-90-
90 goals in Nigeria has been slow with all goals < 35%. Youth and men who have sex with men (MSM), are the
weakest link in Nigeria's response to the HIV epidemic. Interventions reaching youth (including hard-to-reach
MSM) and improving HIV care outcomes across the HIV care continuum should involve combination
interventions as these have additive benefits compared to single interventions. In this study, we propose to
build on infrastructure developed through a very successful U.S-Nigeria HIV-centered academic partnership in
collaboration with partner institutions in Ibadan, Lagos and Jos, Nigeria. We will test two combination
interventions among youths aged 15 to 24 years across the HIV care continuum. In the UG3 phase, we will
(Aim 1) develop manualized interventions for: (a) HIV testing and linkage; and (b) HIV care outcomes among
youth age 15-24 years in Ibadan using a combination approach that includes theoretically-grounded peer
navigation and mHealth components. Once developed we will (Aim 2) test each combination intervention in
pilot trials in Ibadan for feasibility, acceptability and initial efficacy using a pre-post design. The two
interventions include: 2a) social media engagement + peer navigation to improve HIV testing and linkage to
care among young MSM. The pilot test for this intervention will be considered successful if there is an increase
of ≥ 30% in the number of young men completing HIV tests and an increase in the HIV incidence rate by
OR=2.0 over a 48-week period compared to baseline. In addition, we will pilot test: 2b) a short message
service (SMS; via adaptation of an evidence-based intervention, TXTXT) + peer navigation intervention to
improve HIV care outcomes (e.g. care retention, ART adherence and viral suppression) among 40 young
PLWH. This pilot intervention will be considered successful if there is ≥ 30% increase in proportion with viral
load < 1000 copies/mL over a 48-week period, reflecting an effect size of OR=1.5 compared to baseline. We
will also assess feasibility for measurement of medication adherence (via ART concentration in hair) and
retention in care (via medical records abstraction). In the UH3 phase we will (Aim 3) demonstrate the scalability
and efficacy of the two combination interventions in different HIV seroprevalence settings in Nigeria by: 3a)
conducting a randomized stepped wedge trial (5 steps, 6 sites) in Ibadan, Lagos and Jos; and 3b) testing ART
adherence and retention in care as mediators AND age, gender, and mode of transmission as potential
moderators of the HIV care intervention effect. We hypothesize that, using the same primary outcome
measures as in the UG3, the effect size of each combination intervention across and within settings, will be ≥
the effects observed in the UG3. Our goal is to develop efficacious and scalable combination intervention
strategies that will accelerate UNAIDS 90/90/90 goals among Nigerian youths, including MSM.
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DOI:
10.3390/tropicalmed8110498
发表时间:
2023-11-16
期刊:
Tropical medicine and infectious disease
影响因子:
2.9
作者:
[Ahonkhai AA, Kuti KM, Hirschhorn LR, Kuhns LM, Garofalo R, Johnson AK, Adetunji A, Berzins B, Okonkwor O, Awolude O, Omigbodun O, Taiwo BO]
通讯作者:
Taiwo BO
Accelerating adolescent HIV research in low-income and middle-income countries: evidence from a research consortium.
在低收入和中等收入国家中加速青少年艾滋病毒研究:研究财团的证据。
DOI:
10.1097/qad.0000000000003049
发表时间:
2021-12-01
期刊:
AIDS (London, England)
影响因子:
--
作者:
[Tucker JD, Iwelunmor J, Abrams E, Donenberg G, Wilson EC, Blachman-Demner D, Laimon L, Taiwo BO, Kuhns LM, John-Stewart GC, Kohler P, Subramanian S, Ayieko J, Gbaja-Biamila T, Oladele D, Obiezu-Umeh C, Chima KP, Jalil EM, Falcao J, Ezechi OC, Kapogiannis BG]
通讯作者:
Kapogiannis BG
DOI:
10.1097/qai.0000000000002694
发表时间:
2021-08-01
期刊:
Journal of acquired immune deficiency syndromes (1999)
影响因子:
--
作者:
[Taiwo BO, Kuti KM, Kuhns LM, Omigbodun O, Awolude O, Adetunji A, Berzins B, Janulis P, Johnson AK, Okonkwor O, Oladeji BD, Muldoon A, Adewumi OM, Amoo P, Atunde H, Kapogiannis B, Garofalo R]
通讯作者:
Garofalo R
DOI:
10.1371/journal.pone.0258190
发表时间:
2021
期刊:
PloS one
影响因子:
3.7
作者:
[Kuhns LM, Johnson AK, Adetunji A, Kuti KM, Garofalo R, Omigbodun O, Awolude OA, Oladeji BD, Berzins B, Okonkwor O, Amoo OP, Olomola O, Taiwo B]
通讯作者:
Taiwo B
Intensive Combination Approach to Rollback the HIV Epidemic in Nigerian Youth (iCARE) Plus Effectiveness / Implementation Hybrid Study
-
批准号:10749347
-
项目类别:
-
资助金额:$141.02万
-
财政年份:2023
-
负责人:Robert Garofalo
-
依托单位:
MyPEEPS Mobile Plus: A Multi-Level HIV Prevention Intervention for Young MSM
-
批准号:10818851
-
项目类别:
-
资助金额:$116.46万
-
财政年份:2023
-
负责人:Robert Garofalo
-
依托单位:
Development and Testing of MyPEEPS Mobile for Young Transgender Men
-
批准号:10544319
-
项目类别:
-
资助金额:$31.92万
-
财政年份:2022
-
负责人:Robert Garofalo
-
依托单位:
Development and Testing of MyPEEPS Mobile for Young Transgender Men
-
批准号:10407736
-
项目类别:
-
资助金额:$34.15万
-
财政年份:2022
-
负责人:Robert Garofalo
-
依托单位:
mLab App for Improving Uptake of rapid HIV self-testing and Linking Youth to Care
-
批准号:9927670
-
项目类别:
-
资助金额:$81.64万
-
财政年份:2018
-
负责人:Robert Garofalo
-
依托单位:
mLab App for Improving Uptake of rapid HIV self-testing and Linking Youth to Care
-
批准号:10404092
-
项目类别:
-
资助金额:$77.24万
-
财政年份:2018
-
负责人:Robert Garofalo
-
依托单位:
mLab App for Improving Uptake of rapid HIV self-testing and Linking Youth to Care
-
批准号:10160957
-
项目类别:
-
资助金额:$81.58万
-
财政年份:2018
-
负责人:Robert Garofalo
-
依托单位:
mLab App for Improving Uptake of rapid HIV self-testing and Linking Youth to Care
-
批准号:9755512
-
项目类别:
-
资助金额:$82.92万
-
财政年份:2018
-
负责人:Robert Garofalo
-
依托单位:
Adaptive intervention strategies trial for strengthening adherence to antiretroviral HIV treatment among youth
-
批准号:10371803
-
项目类别:
-
资助金额:$59.15万
-
财政年份:2016
-
负责人:Robert Garofalo
-
依托单位:
A Pragmatic Clinical Trial of MyPEEPS Mobile to Improve HIV prevention Behaviors in Diverse Adolescent MSM
-
批准号:9902191
-
项目类别:
-
资助金额:$157.58万
-
财政年份:2016
-
负责人:Robert Garofalo
-
依托单位:
Adaptive intervention strategies trial for strengthening adherence to antiretroviral HIV treatment among youth
-
批准号:9357686
-
项目类别:
-
资助金额:$62.78万
-
财政年份:2016
-
负责人:Robert Garofalo
-
依托单位:
A Pragmatic Clinical Trial of MyPEEPS Mobile to Improve HIV prevention Behaviors in Diverse Adolescent MSM
-
批准号:9569861
-
项目类别:
-
资助金额:$7.96万
-
财政年份:2016
-
负责人:Robert Garofalo
-
依托单位:
Employing eSBI in a Community-based HIV Testing Environment for At-risk Youth
-
批准号:9054477
-
项目类别:
-
资助金额:$64.08万
-
财政年份:2015
-
负责人:Robert Garofalo
-
依托单位:
CVCTPlus: A Couples-Based Approach to Linkage to Care and ARV Adherence
-
批准号:8556766
-
项目类别:
-
资助金额:$69.15万
-
财政年份:2013
-
负责人:Robert Garofalo
-
依托单位:
CVCTPlus: A Couples-Based Approach to Linkage to Care and ARV Adherence
-
批准号:9247834
-
项目类别:
-
资助金额:$47.74万
-
财政年份:2013
-
负责人:Robert Garofalo
-
依托单位:
CVCTPlus: A Couples-Based Approach to Linkage to Care and ARV Adherence
-
批准号:8650296
-
项目类别:
-
资助金额:$59.38万
-
财政年份:2013
-
负责人:Robert Garofalo
-
依托单位:
CVCTPlus: A Couples-Based Approach to Linkage to Care and ARV Adherence
-
批准号:8826797
-
项目类别:
-
资助金额:$60.29万
-
财政年份:2013
-
负责人:Robert Garofalo
-
依托单位:
HIV Prevention Intervention for Young Transgender Women
-
批准号:8215419
-
项目类别:
-
资助金额:$74.22万
-
财政年份:2011
-
负责人:Robert Garofalo
-
依托单位:
HIV Prevention Intervention for Young Transgender Women
-
批准号:8457098
-
项目类别:
-
资助金额:$74.92万
-
财政年份:2011
-
负责人:Robert Garofalo
-
依托单位:
HIV Prevention Intervention for Young Transgender Women
-
批准号:8280327
-
项目类别:
-
资助金额:$71.58万
-
财政年份:2011
-
负责人:Robert Garofalo
-
依托单位:
海外基金