A Pragmatic Clinical Trial of MyPEEPS Mobile to Improve HIV prevention Behaviors in Diverse Adolescent MSM

MyPEEPS Mobile 改善不同青少年 MSM 的 HIV 预防行为的实用临床试验

• 批准号: 9902191
• 负责人: Robert Garofalo
• 金额: $ 157.58万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9902191
• 关键词: 18 year old; AIDS prevention; AIDS/HIV problem; Address; Adolescent; Affect; Age; Alcohols; Anus; Behavior; Behavior Therapy; Behavioral; Car Phone; Caricatures; Cellular Phone; Chicago; Computers; Devices; Educational Curriculum; Ensure; Ethnic group; Evidence based intervention; FDA approved; Family; Frequencies; Geography; Goals; HIV; HIV Infections; HIV Seronegativity; HIV/STD; Health; Incidence; Individual; Intervention; Knowledge; Latino; Level of Evidence; Life; Link; Literature; Minority Groups; Nature; New York City; Online Systems; Oral; Oral Sex; Participant; Patient Self-Report; Personal Communication; Persons; Pharmaceutical Preparations; Population; Population Group; Populations at Risk; Pragmatic clinical trial; Preventive Intervention; Privacy; Prophylactic treatment; Public Health; Randomized; Randomized Controlled Trials; Reporting; Research; Risk; Safe Sex; Sampling; Schedule; Self Efficacy; Sexual Health; Sexual Partners; Site; Structure; Tablets; Testing; Time; Translating; Translations; Travel; Unsafe Sex; Update; Ursidae Family; Work; adolescent men who have sex with men; age group; aged; base; condomless anal sex; condoms; cost; design; efficacy testing; ethnic diversity; ethnic minority population; evidence base; experience; group intervention; high risk; high risk sexual behavior; improved; mHealth; male; member; men who have sex with men; mobile computing; multi-site trial; novel; pilot trial; portability; pre-exposure prophylaxis; primary outcome; racial and ethnic; racial diversity; racial minority; response; scale up; sexual risk behavior; skills; social; theories; user centered design; web-enabled; young men who have sex with men

PROJECT SUMMARY Men who have sex with men (MSM) bear a greater burden of HIV/AIDS than any other population group in the US, comprising only 2% of the population but 56% of individuals living with HIV/AIDS. Although much of the increased incidence in HIV has been reported among young MSM (YMSM), especially among racial and ethnic minority groups, and is linked to high-risk sexual behavior, there remains a dearth of evidence-based HIV prevention interventions for YMSM – and none that address racially/ethnically diverse YMSM. To address this need, our study, in response to RFA-MD-15-012, leverages mobile technology and MyPEEPS, an existing theory-driven, multi-ethnic, group-level, evidence-based intervention for diverse YMSM. MyPEEPS is a manualized curriculum, developed by members of our proposed Investigative team, comprised of 6 modules focusing on key intermediate social and personal factors, including knowledge (e.g., correct way to use a condom), self-efficacy for safer sex, interpersonal communication skills and behavioral skills. MyPEEPS is one of the only HIV prevention interventions in the literature that focuses on diverse adolescent MSM. Long-term sustainability of face-to face, group-level behavioral interventions, such as MyPEEPS, have been problematic for dissemination in at-risk populations, particularly among young racial and ethnic minority groups. In response to this challenge, we propose to translate MyPEEPS from a face-to-face, group-based curriculum to a mobile, responsive-driven web-based platform, accessible by smartphone or other web-enabled devices, to increase accessibility and scalability for diverse YMSM. The ubiquitous nature of mobile phones in daily life, especially among 13-18 year olds, has created opportunities for health interventions in a portable format with enhanced privacy. Using a participatory approach, our study will incorporate user-centered design in the translation of the MyPEEPS intervention onto a mobile platform. MyPEEPS Mobile will be tested in an RCT with racially and ethnically diverse HIV-negative or unknown status YMSM aged 13-18 at four geographically diverse sites: Birmingham, Chicago, New York City, and Seattle, allowing for increased generalizability of findings. The proposed MyPEEPS Mobile intervention is a novel and evidence-driven intervention using mobile technology to deliver HIV prevention information specifically developed for at-risk YMSM. This will be the one of the first studies to test the efficacy of a scaled-up, mobile version of an existing HIV prevention intervention originally developed for, designed by, and piloted for, a diverse group of YMSM. The research team has unique experience and expertise to conduct this important work and has conducted significant preliminary work related to the project goals. If efficacious, the public health impact is large, as the intervention will already be in mobile format which is well-suited for widespread dissemination.

项目总结 男男性行为者(MSM)感染艾滋病毒/艾滋病的负担比世界上任何其他人群都要大 美国，仅占人口的2%，但感染艾滋病毒/艾滋病的个人占56%。 尽管大部分的 据报道，青年男男性接触者(YMSM)的艾滋病毒发病率有所增加，特别是在种族和民族中 少数群体，并与高危性行为有关，仍然缺乏以证据为基础的艾滋病毒 针对基督教青年会的预防干预措施--没有针对种族/人种多样性的青年会的干预措施。要解决这个问题 需要，我们的研究响应RFA-MD-15-012，利用移动技术和MyPEEPS，现有的 理论驱动的、多种族的、群体层面的、以证据为基础的对不同的基督教青年会的干预。MyPEEPS是一种 由我们建议的调查团队成员开发的手动课程，由6个模块组成 关注关键的中间社会和个人因素，包括知识(例如，正确使用 安全套)、安全性行为的自我效能感、人际沟通技巧和行为技巧。MyPEEPS就是其中之一 是文献中仅有的侧重于不同青少年男男性接触者的艾滋病毒预防干预措施。长期的 面对面、群体级别的行为干预措施，如MyPEEPS的可持续性一直存在问题 在高危人群中传播，特别是在年轻的种族和少数民族群体中传播。在……里面 为了应对这一挑战，我们建议将MyPEEPS从面对面的、基于小组的课程转换为 移动、响应驱动的基于Web的平台，可通过智能手机或其他支持Web的设备访问，以 提高各种YMSM的可访问性和可扩展性。手机在日常生活中无处不在的本质， 特别是在13-18岁的青少年中，创造了以便携形式进行健康干预的机会 增强了隐私。使用参与式方法，我们的研究将把以用户为中心的设计融入 将MyPEEPS干预措施翻译到移动平台上。MyPEEPS Mobile将在RCT中进行测试 患有不同种族和民族的HIV阴性或未知状态的YMSM，年龄13-18岁，在四个地理位置 多样化的站点：伯明翰、芝加哥、纽约市和西雅图，从而提高了 调查结果。建议的MyPEEPS移动干预是一种新颖的、以证据为导向的使用移动干预 提供专门为高危YMSM开发的艾滋病毒预防信息的技术。这将是一个 测试现有艾滋病毒预防干预措施的扩大、移动版本的有效性的首批研究 最初是为不同的YMSM群体开发、设计和试点的。研究团队拥有独一无二的 进行这项重要工作的经验和专业知识，并进行了有关的重大前期工作 向项目目标致敬。如果有效，对公共健康的影响是巨大的，因为干预已经在移动中进行 一种非常适合广泛传播的格式。

项目成果

Examining the Information Systems Success (ISS) of a mobile sexual health app (MyPEEPS Mobile) from the perspective of very young men who have sex with men (YMSM).

• DOI: 10.1016/j.ijmedinf.2021.104529
• 发表时间: 2021-09
• 期刊: International journal of medical informatics
• 影响因子: 4.9
• 作者: Cordoba E;Idnay B;Garofalo R;Kuhns LM;Pearson C;Bruce J;Batey DS;Radix A;Belkind U;Hidalgo MA;Hirshfield S;Rodriguez RG;Schnall R
• 通讯作者: Schnall R

Homonegative Victimization and Perceived Stress among Adolescent Sexual Minority Males: The Attenuating Role of Peer and Family Support.

青少年性少数男性的同性受害和感知压力：同伴和家庭支持的减弱作用。

• DOI: 10.1080/19317611.2022.2124341
• 发表时间: 2022
• 期刊: International journal of sexual health : official journal of the World Association for Sexual Health
• 作者: Gordián-Arroyo,Alvin;Schnall,Rebecca;Garofalo,Robert;Kuhns,LisaM;Pearson,Cynthia;Bruce,Josh;ScottBatey,D;Radix,Asa;Belkind,Uri;Hirshfield,Sabina;Hidalgo,MarcoA
• 通讯作者: Hidalgo,MarcoA

Risk-taking behaviors in adolescent men who have sex with men (MSM): An association between homophobic victimization and alcohol consumption.

• DOI: 10.1371/journal.pone.0260083
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Cordoba E;Garofalo R;Kuhns LM;Pearson C;Bruce J;Batey DS;Radix A;Belkind U;Hidalgo MA;Hirshfield S;Garibay Rodriguez R;Schnall R
• 通讯作者: Schnall R

Preliminary Results from a Pragmatic Clinical Trial of MyPEEPS Mobile to Improve HIV Prevention Behaviors in Young Men.

• DOI: 10.3233/shti200444
• 发表时间: 2020-06-16
• 期刊: Studies in health technology and informatics
• 作者: Schnall R;Kuhns L;Pearson C;Bruce J;Batey DS;Radix A;Belkind U;Hidalgo MA;Hirshfield S;Ganzhorn S;Garofalo R
• 通讯作者: Garofalo R

A Mobile Health Intervention for HIV Prevention Among Racially and Ethnically Diverse Young Men: Usability Evaluation.

• DOI: 10.2196/11450
• 发表时间: 2018-09-07
• 期刊: JMIR mHealth and uHealth
• 影响因子: 5
• 作者: Cho H;Powell D;Pichon A;Thai J;Bruce J;Kuhns LM;Garofalo R;Schnall R
• 通讯作者: Schnall R