RAE Health I-Corps

RAE Health I-Corps

• 批准号: 10045689
• 负责人: STEPHANIE P CARREIRO
• 金额: $ 5.5万
• 依托单位: CONTINUEYOU, LLC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-15 至 2020-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10045689
• 关键词: Advisory Committees; Alcohol or Other Drugs use; Algorithms; Biological Markers; Biosensor; Businesses; Clinical; Data; Detection; Devices; Drug usage; Engineering; Evaluation; Event; Geographic Locations; Goals; Health; Health Personnel; Individual; Innovation Corps; Intervention; Leadership; Locomotion; Manuals; Medicine; Monitor; Morbidity - disease rate; Patients; Physical activity; Physiology; Population; Recovery; Relapse; Research; Research Personnel; Research Project Grants; Research Project Summaries; Skin Temperature; Sleep; Small Business Innovation Research Grant; Specific qualifier value; Stress; Substance Use Disorder; Support System; System; Techniques; Technology; Text; Time; User Compliance; Wrist; base; cloud based; craving; digital; high risk; improved; mortality; personalized medicine; relapse risk; sensor; smart watch; smartphone Application; sobriety; stress reduction; success; tool; treatment program; usability; wearable device; wearable sensor technology

! PROJECT SUMMARY The research project outlined in this SBIR submission will develop the Realize, Analyze, Engage (RAE) platform into a tool to promote sustained recovery in individuals receiving treatment for substance use disorder. In this proposal, the investigators intend to deploy the RAE system- consisting of a wearable sensor, a smartphone app, and a clinical portal- to provide individuals in recovery and their treatment providers with an opportunity to identify moments of high risk for relapse and to access real time intervention opportunities. Wearable biosensors are small, noninvasive devices that continuously record physiology. These sensors have the ability to detect digital biomarkers of drug use, craving and stress, the latter of which herald an increased risk of relapse. RAE aims to utilize this capability to create a real-time solution for individuals in recovery. The components of RAE are: 1) The Empatica Embrace and/or Garmin VivoSmart, a wrist mounted sensor similar in form factor to a smart watch, that continuously monitors skin temperature, electrodermal activity (EDA) and locomotion. Detection algorithms for stress, craving and drug use will be embedded on the Embrace firmware. 2) The RAE smartphone application (app), for the individual in recovery. The app will be triggered either by detection of an event on the Embrace or manually by the user when needed and will provide multiple options for annotations, stress reduction techniques and immediate contact with individuals in the pre-defined support system via call or SMS text. The app will also log sleep, physical activity, and geographic location of events. 3) The RAE Portal, for the treatment provider, will deliver alerts when an event is detected on the user’s device for the opportunity to intervene in real time and will also provide metrics on the user’s recorded activities. The research plan has two Specific Aims: Aim 1) Technology Deployment: To deploy and optimize the RAE system in a population of individuals in treatment for substance use disorder and Aim 2) Aim 2: Technology Evaluation and Optimization: To evaluate the compliance, usability and accuracy of the RAE system To achieve these aims, the investigators will first deploy the technology in a population of individuals in recovery and collect data on accuracy, usability and functionality (Aim 1). The data from Aim 1 will be used to optimize the system and achieve millstones in Aim 2 which will include sensitivity, specify, accuracy and user compliance targets. The investigators have assembled a leadership team and advisory team with the necessary expertise in business, medicine, wearable technology and engineering to develop RAE into a tool that dramatically improves the success of treatment for substance use disorder, promotes sustained sobriety, and reduces morbidity and mortality from relapse to substance use. !

呢 项目摘要 SBIR提交中概述的研究项目将发展实现，分析，参与（RAE） 平台成为一种促进接受药物使用障碍治疗的个体持续恢复的工具。 在此提案中，调查人员打算部署由可穿戴传感器组成的RAE系统 智能手机应用程序以及临床门户 - 可为康复中的个人及其治疗提供者提供 确定救济高风险并获得实时干预机会的机会。 可穿戴生物传感器是不断记录生理学的小型无创设备。这些传感器具有 检测药物使用，渴望和压力的数字生物标志物的能力，后者的预示增加了 退休风险。 RAE旨在利用此能力为康复中的个体创建实时解决方案。这 Rae的组件是：1）empatica拥抱和/或Garmin Vivosmart，手腕安装的传感器相似 以智能手表的形式，可以不断地监视皮肤温度，电肌活动（EDA）和 运动。用于压力，渴望和吸毒的检测算法将嵌入在拥抱中 固件。 2）RAE智能手机应用程序（APP），用于恢复中的个人。该应用将被触发 通过在需要时检测到拥抱的事件，或者在需要时手动手动，并将提供多个 注释，减轻压力技术的选项以及与预定义的个人的立即接触 通过呼叫或SMS文本支持系统。该应用还将记录睡眠，体育锻炼和地理位置 事件。 3）对于治疗提供商，RAE门户将在检测到事件时发出警报 用户的设备有机会实时干预，还将提供用户记录的指标 活动。研究计划有两个具体的目的：目标1）技术部署：部署和优化 在治疗药物使用障碍治疗的人群中的RAE系统和目标2）目标2： 技术评估和优化：评估RAE的合规性，可用性和准确性 为了实现这些目标的系统，调查人员将首先将技术部署在一个人群中 恢复并收集有关准确性，可用性和功能的数据（AIM 1）。来自AIM 1的数据将用于 优化系统并在AIM 2中实现磨石，其中包括灵敏度，指定，准确和用户 合规目标。调查人员已与 业务，医学，可穿戴技术和工程学的必要专业知识，以将RAE开发为工具 这极大地改善了治疗物质使用障碍的成功，促进了持续清醒的 并降低了从救济到药物使用的发病率和死亡率。 呢