RAE Health I-Corps

! 项目摘要 SBIR提交的研究项目将开发实现，分析，参与（RAE） 平台转化为工具，以促进接受药物使用障碍治疗的个人的持续康复。 在这项提案中，研究人员打算部署RAE系统-由可穿戴传感器， 智能手机应用程序和临床门户-为康复中的个人及其治疗提供者提供 有机会确定复发的高风险时刻，并获得真实的时间干预机会。 可穿戴生物传感器是一种小型、非侵入性的设备，可以连续记录生理状态。这些传感器具有 检测药物使用，渴望和压力的数字生物标志物的能力，后者预示着增加 复发的风险。RAE旨在利用这一能力为恢复中的个人创建实时解决方案。的 RAE的组件是：1）Empatica Embrace和/或Garmin VivoSmart，一种类似于手腕安装的传感器 在智能手表的外形中，它连续监测皮肤温度、皮肤电活动（EDA）， 运动压力、渴望和药物使用的检测算法将嵌入Embrace 固件. 2)RAE智能手机应用程序（应用程序），用于恢复中的个人。应用程序将被触发 或者通过在Embrace上检测事件，或者在需要时由用户手动， 选项的注释，减压技术和直接接触的个人在预定义的 通过电话或短信支持系统。该应用程序还将记录睡眠，身体活动和地理位置， 事件3)治疗提供者的RAE门户将在检测到事件时发出警报。 用户的设备进行真实的干预的机会，也将提供有关用户记录的指标 活动研究计划有两个具体目标：目标1）技术部署：部署和优化 正在接受药物使用障碍治疗的人群中的RAE系统和目标2）目标2： 技术评估和优化：评估RAE的合规性、可用性和准确性 为了实现这些目标，研究人员将首先在一群人中部署这项技术， 恢复和收集关于准确性、可用性和功能的数据（目标1）。目标1的数据将用于 优化系统，实现目标2中的目标，包括灵敏度、特异性、准确性和用户 合规目标。调查人员已经组建了一个领导小组和咨询小组， 在商业，医学，可穿戴技术和工程方面的必要专业知识，将RAE发展成为一种工具 这极大地提高了药物使用障碍治疗的成功率，促进了持续的清醒， 并降低因复发而导致的发病率和死亡率。 !

! PROJECT SUMMARY The research project outlined in this SBIR submission will develop the Realize, Analyze, Engage (RAE) platform into a tool to promote sustained recovery in individuals receiving treatment for substance use disorder. In this proposal, the investigators intend to deploy the RAE system- consisting of a wearable sensor, a smartphone app, and a clinical portal- to provide individuals in recovery and their treatment providers with an opportunity to identify moments of high risk for relapse and to access real time intervention opportunities. Wearable biosensors are small, noninvasive devices that continuously record physiology. These sensors have the ability to detect digital biomarkers of drug use, craving and stress, the latter of which herald an increased risk of relapse. RAE aims to utilize this capability to create a real-time solution for individuals in recovery. The components of RAE are: 1) The Empatica Embrace and/or Garmin VivoSmart, a wrist mounted sensor similar in form factor to a smart watch, that continuously monitors skin temperature, electrodermal activity (EDA) and locomotion. Detection algorithms for stress, craving and drug use will be embedded on the Embrace firmware. 2) The RAE smartphone application (app), for the individual in recovery. The app will be triggered either by detection of an event on the Embrace or manually by the user when needed and will provide multiple options for annotations, stress reduction techniques and immediate contact with individuals in the pre-defined support system via call or SMS text. The app will also log sleep, physical activity, and geographic location of events. 3) The RAE Portal, for the treatment provider, will deliver alerts when an event is detected on the user’s device for the opportunity to intervene in real time and will also provide metrics on the user’s recorded activities. The research plan has two Specific Aims: Aim 1) Technology Deployment: To deploy and optimize the RAE system in a population of individuals in treatment for substance use disorder and Aim 2) Aim 2: Technology Evaluation and Optimization: To evaluate the compliance, usability and accuracy of the RAE system To achieve these aims, the investigators will first deploy the technology in a population of individuals in recovery and collect data on accuracy, usability and functionality (Aim 1). The data from Aim 1 will be used to optimize the system and achieve millstones in Aim 2 which will include sensitivity, specify, accuracy and user compliance targets. The investigators have assembled a leadership team and advisory team with the necessary expertise in business, medicine, wearable technology and engineering to develop RAE into a tool that dramatically improves the success of treatment for substance use disorder, promotes sustained sobriety, and reduces morbidity and mortality from relapse to substance use. !