Neuroimaging approaches to improve prediction of smoking initiation and nicotine use escalation among young adult electronic nicotine delivery systems users

神经影像学方法可改善年轻成人电子尼古丁输送系统用户吸烟开始和尼古丁使用升级的预测

• 批准号: 10054474
• 负责人: Jiaying Liu
• 金额: $ 17.4万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10054474
• 关键词: Address; Adult; Alcohol or Other Drugs use; Awareness; Back; Behavior assessment; Behavioral; Brain; Communication; Competence; Complement; Cotinine; Crossover Design; Cues; Data; Dependence; Desire for food; Development; Electronic Mail; Electronic Nicotine Delivery Systems; Emotions; Epidemic; Evaluation; Exhalation; Food; Functional Magnetic Resonance Imaging; Goals; Grant; Health Campaign; Intervention; Link; Liquid substance; Maintenance; Marketing; Measures; Mediating; Nature; Neurocognitive; Neurosciences; Neurosciences Research; Nicotine; Nicotine Dependence; Outcome; Palate; Participant; Patient Self-Report; Persons; Policies; Predisposition; Prevention; Process; Psychological reinforcement; Public Health; Randomized Controlled Trials; Recommendation; Regulation; Reporting; Research; Research Personnel; Research Training; Rewards; Risk; Risk Assessment; Risk Factors; Risk Marker; Safety; Services; Severities; Smoke; Smoker; Smoking; Stimulus; Surveys; System; Testing; Time; TimeLine; Tobacco; Tobacco use; Training; Translating; Urine; Visit; Visual; Vulnerable Populations; Writing; addiction; aerosolized; career development; cigarette smoke; cigarette smoking; cognitive control; communication behavior; craving; cue reactivity; design; experience; high risk population; improved; incentive salience; indexing; neurobehavioral; neuroimaging; never smoking; nicotine use; non-smoking; novel; outcome prediction; predictive marker; primary outcome; relating to nervous system; research study; resilience; response; success; tobacco control; tobacco prevention; tobacco products; tobacco regulatory science; vaper; vaping; young adult

PROJECT SUMMARY/ABSTRACT The proposed career development application provides research training for Dr. Jiaying Liu to facilitate her transition to independence. The goal of the proposed research is to identify neurobehavioral makers of nicotine use escalation and cigarette smoking initiation among young adult (YA) users of electronic nicotine delivery systems (ENDS). Findings are expected to inform regulatory policy and improve YA responsiveness to public health campaign communications. Given the accumulating evidence that ENDS use conveys 5-fold additional risk for smoking initiation and other tobacco use escalation, recent YA increases in use are alarming, threatening a resurgence of dependence that may reverse decades of tobacco control success. Therefore, it is crucial to identify predictive markers of smoking initiation and tobacco use escalation in this vulnerable population, and to provide actionable evidence that informs regulatory and prevention efforts. Functional magnetic resonance imaging (fMRI) generates information complementary to traditional behavioral risk assessments, with direct observations of the neural substrates that underlie the subjective states known to perpetuate addiction, in order to yield objective and putatively more predictive measures. Assessment of behavioral and brain markers associated with smoking onset and tobacco use escalation is proposed. The goal is to determine whether baseline neurobehavioral markers will predict smoking transition and tobacco use escalation beyond traditional makers at 3, 6, 9 and 12 months. A one-year public service announcement (PSA) intervention with a cross-over design will also be conducted, in which two message exposure orders and one control condition allow testing whether novel anti-ENDS PSAs addressing harms associated with ENDS flavors will more effectively prevent tobacco use escalation compared to the existing regular PSAs. The proposed research is among the first that aims to inform regulation of flavored ENDS marketing, and to provide recommendations for developing effective PSAs for prevention campaigns. These aims directly address multiple priorities of FDA Center for Tobacco Products (Marketing Influences, Communications, Behavior and Addiction), and they are expected to pinpoint effective regulatory gates to address the current ENDS epidemic. Dr. Liu’s long-term goal is to become an independent researcher translating communication neuroscience research to regulatory actions for improvements in health campaigns and interventions utilizing persuasive anti-tobacco messaging. Her near-term goal is to prepare a competitive R01 application to implement randomized controlled trials of PSAs to maximize impact on deterrence of smoking and substance use transition among ENDS users. The proposed training experience is designed to develop competencies in (a) neuroscience, (b) functional neuroimaging, (c) tobacco regulatory science, and (d) grant writing. The proposed research study provides focus for training and preliminary data to support a competitive R01 application.

项目总结/文摘