Schistosomiasis at the edge of elimination: characterizing sources of new infections in residual transmission hotspots

血吸虫病即将被消灭:残留传播热点地区新感染源的特征

基本信息

  • 批准号:
    10057216
  • 负责人:
  • 金额:
    $ 71.14万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-11-23 至 2023-10-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Schistosomiasis, a waterborne infection that affects approximately 200 million people, persists in some areas despite aggressive control measures, for reasons that are not well understood. Hotspots of schistosomiasis persistence and reemergence have been documented in parts of China and, more recently, sub-Saharan Africa. These hotspots threaten to disrupt global targets for schistosomiasis elimination, and highlight the need to understand the origins of new infections in these areas to improve control strategies. Plausible infection sources include human hosts within a community, other mammalian species, and imported infections via, for example, mobile human hosts. However, the actual contributions of such sources to the sustained transmission of complex macroparasites such as schistosomiasis in areas under control pressure is poorly resolved. Genomic tools offer the potential to discern detailed transmission pathways, even for highly inbred parasites such as schistosomes. The proposed research leverages genomic approaches and longitudinal epidemiological data to identify origins of new infections in transmission hotspots. High-resolution sequencing and analysis methods for Schistosoma japonicum will be used to infer parasite ancestry across generations, allowing identification of hosts that serve as infection sources. Over ten years of longitudinal data from southwest China, and ongoing access to schistosomiasis hotspots will be used to characterize host and village-level characteristics that predict the contribution of distinct hosts and the contributions of parasite import to transmission. Specifically, the three proposed aims will evaluate evidence that high transmission human hosts (superspreaders) serve as sources of new infections (Aim 1), identify the conditions that facilitate the contributions of non-human hosts to infection (Aim 2), and test for and identify if present key pathways of parasite import (Aim 3). The ambitious goals for the control of schistosomiasis and other neglected tropical diseases and the persistence of the disease in transmission hotspots despite control measures highlights the need for new approaches to prevent transmission. By determining the extent to which new infections are coming from human hosts, animal hosts, or movement between villages, it will be possible to fine-tune control efforts to focus on key sources of infection in areas approaching elimination.
项目摘要/摘要 血吸虫病是一种通过水传播的传染病,影响着大约2亿人,在一些地区持续存在。 尽管采取了积极的控制措施,但原因尚不清楚。血吸虫病热点 在中国的部分地区,以及最近在撒哈拉以南地区,都记录到了顽固和卷土重来 非洲。这些热点可能会扰乱全球消灭血吸虫病的目标,并突显了 了解这些地区新感染病例的来源,以改进控制策略。疑似感染 来源包括社区内的人类宿主,其他哺乳动物物种,以及通过以下途径输入的感染 例如,移动的人类主机。然而,这些来源对可持续发展的实际贡献 血吸虫病等复杂大型寄生虫在有控制压力的地区传播较差 解决了。基因组工具提供了识别详细的传播途径的潜力,即使是高度近亲繁殖的 寄生虫,如血吸虫。拟议的研究利用基因组方法和纵向 流行病学数据,以确定传播热点地区新感染的来源。高分辨率测序 日本血吸虫的分析方法将被用来推断寄生虫的世代祖先, 从而能够识别作为感染源的宿主。十多年的纵向数据来自 西南中国,以及持续进入血吸虫病热点地区将被用来表征宿主和 村级特征预测不同宿主的贡献和寄生虫输入的贡献 转到变速箱。具体地说,这三个提议的目标将评估高传播率人类 宿主(超级传播者)作为新的感染源(目标1),确定促进 非人类宿主对感染的贡献(目标2),并测试和确定目前的关键途径 寄生虫进口(目标3)。血吸虫病和其他被忽视的热带疾病控制的宏伟目标 疾病和疾病在传播热点地区的持久性,尽管采取了控制措施,但突出了 需要新的方法来防止传播。通过确定新感染的程度 来自人类宿主、动物宿主或村庄之间的流动,将有可能微调控制 努力将重点放在接近消灭的地区的关键感染源上。

项目成果

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Elizabeth Carlton其他文献

Elizabeth Carlton的其他文献

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{{ truncateString('Elizabeth Carlton', 18)}}的其他基金

Schistosomiasis at the edge of elimination: characterizing sources of new infections in residual transmission hotspots
血吸虫病即将被消灭:残留传播热点地区新感染源的特征
  • 批准号:
    10508509
  • 财政年份:
    2018
  • 资助金额:
    $ 71.14万
  • 项目类别:
Schistosomiasis at the edge of elimination: characterizing sources of new infections in residual transmission hotspots
血吸虫病即将被消灭:残留传播热点地区新感染源的特征
  • 批准号:
    10294247
  • 财政年份:
    2018
  • 资助金额:
    $ 71.14万
  • 项目类别:
Identifying parasite reservoirs in areas approaching elimination
确定即将消除的地区的寄生虫储存库
  • 批准号:
    9102040
  • 财政年份:
    2015
  • 资助金额:
    $ 71.14万
  • 项目类别:

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