Small Animal Studies Core

小动物研究核心

• 批准号: 10059197
• 负责人: Anna M Wu
• 金额: $ 6.27万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10059197
• 关键词: Advanced Development; Advisory Committees; Animal Experimentation; Animal Experiments; Animal Model; Animals; Antineoplastic Agents; Bioluminescence; Brain; Breast; Cancer Biology; Cancer Center Support Grant; Cell physiology; City of Hope Comprehensive Cancer Center; Clinic; Clinical; Collaborations; Colorectal; Colorectal Cancer; Computer software; Consult; Consultations; Data; Data Analyses; Data Collection; Development; Diagnosis; Direct Costs; Drug Delivery Systems; Education; Ensure; Equipment; Evaluation; Faculty; Feedback; Fluorescence; Funding; Goals; Grant; Guidelines; Hazardous Substances; Hematologic Neoplasms; Hematopoietic Neoplasms; Hepatocyte; Human; Huntington Disease; IACUC; Image; Imaging Device; Imaging Techniques; Imaging technology; Immune system; ImmunoPET; Immunodeficient Mouse; Individual; Infection; Kidney; Laboratories; Liver; Lung; Maintenance; Medicine; Modeling; Molecular; Molecular Immunology; Monitor; Monoclonal Antibodies; Multimodal Imaging; NCI Center for Cancer Research; Pancreas; Peer Review; Performance; Pharmaceutical Preparations; Physicians; Positron-Emission Tomography; Postdoctoral Fellow; Predisposition; Preparation; Procedures; Prostate; Protocols documentation; Radiation; Radioactive; Radiolabeled; Radionuclide Imaging; Reagent; Reporting; Research; Research Personnel; Research Support; Resource Sharing; Resources; Schedule; Scientist; Services; Solid Neoplasm; Support System; Surveys; System; Techniques; Therapeutic Agents; Toxic effect; Training; Translating; United States National Institutes of Health; Xenograft Model; Xenograft procedure; animal imaging; animal resource; anticancer research; base; cancer immunotherapy; comparative; cost effective; design; drug development; drug metabolism; experimental study; humanized mouse; imaging study; in vivo; in vivo imaging; individual patient; instrument; instrumentation; investigator training; leukemia/lymphoma; lung sarcoma; malignant stomach neoplasm; member; model design; mouse model; neoplastic cell; next generation; novel; operation; optical imaging; organizational structure; patient derived xenograft model; pharmacokinetics and pharmacodynamics; pre-clinical; precision medicine; preclinical study; professor; research and development; response; service delivery; single photon emission computed tomography; square foot; stem cell therapy; targeted agent; theories; theranostics; therapeutic development; translational cancer research; treatment response; tumor; tumor growth

Small Animal Studies Core Shared Resource ABSTRACT The Small Animal Studies Core (SASC) combines the resources available through the previously reviewed Small Animal Imaging Core with a new Animal Tumor Models component. This combined resource provides exceptional quality services for City of Hope Comprehensive Cancer Center (COHCCC) members for basic and translational preclinical studies in cancer biology, anti-cancer drug development, and stem cell therapeutic development. The Small Animal Imaging component of the SASC provides consultation, advanced imaging equipment, imaging services, hands-on training for COHCCC members, and support for protocol and grant preparation. Current systems in the Imaging Laboratory include two units for bioluminescence/fluorescence optical imaging (Ami X and Lago X from Spectral Instruments Imaging) and a PET/SPECT/CT trimodal scanner (Inveon from Siemens). These systems support molecular-based imaging to allow for the monitoring of cellular processes and the non-invasive assessment of pharmacokinetics and pharmacodynamics of therapeutic agents. Often the imaging techniques and targeting agents utilized are directly transferable to the clinical setting. The Animal Tumor Models component of the SASC has established patient-derived xenograft (PDX) models of breast, colorectal, lung, sarcoma, and gastric cancers in collaboration with COHCCC physician scientists and has developed next-generation humanized mouse models for research in cancer immunotherapy and in vivo drug metabolism/toxicity studies. The development of PDX models supports precision medicine by allowing investigators to evaluate tumor growth and therapeutic response for individual patients. The Animal Tumor Models component also provides specialized drug delivery services, training for in vivo procedures, and support for protocol preparation and grant development. The SASC is co-directed by Dr. David Colcher, a Professor in the Department of Molecular Immunology, and Dr. Jun Wu, an Associate Research Professor of Comparative Medicine, and is supported by highly qualified staff that maintain and operate the instrumentation. Oversight is provided by an interdisciplinary faculty Advisory Committee, and user feedback through an annual survey. The SASC occupies three rooms within the 29,000 sq. ft. Parvin Building for animal experiments and two rooms in Huntington Lab for tumor cell and reagent preparation. iLab software is used to schedule services, monitor instrument use, and manage billing within the SASC. Over the previous five years, the SASC was used by 80 unique investigators, including 58 CC members. Of the 58 CC members, 48 (83%) had peer-reviewed funding. As of this report, the SASC provides ongoing support to 12 NIH-funded projects totaling $5.6M per year in direct costs to the COHCCC.

小动物研究核心共享资源 摘要 小动物研究核心(SASC)结合了通过以前审查的Small 具有新的动物肿瘤模型组件的动物成像核心。这一组合资源可提供 为希望之城综合癌症中心(COHCCC)成员提供优质的基础和 癌症生物学、抗癌药物开发和干细胞治疗方面的转译临床前研究 发展。 SASC的小动物成像部分提供咨询、先进的成像设备、 成像服务，对COHCCC成员的实践培训，以及对礼宾和赠款准备的支持。 成像实验室目前的系统包括两个生物发光/荧光光学成像装置 (光谱仪器成像公司的Ami X和Lago X)和一台PET/SPECT/CT三模扫描仪(Inveon来自 西门子)。这些系统支持基于分子的成像，以允许监视细胞过程和 对治疗剂的药代动力学和药效学的非侵入性评估。通常情况下 所使用的成像技术和靶向试剂可直接转移到临床环境中。 SASC的动物肿瘤模型组件已经建立了患者来源的异种移植(PDX)模型 乳腺癌、结直肠癌、肺癌、肉瘤和胃癌与COHCCC内科科学家和 开发了新一代人源化小鼠模型，用于癌症免疫治疗和体内研究 药物代谢/毒性研究。PDX模型的开发支持精确医学，允许 研究人员对个别患者的肿瘤生长和治疗反应进行评估。动物肿瘤 Models组件还提供专门的药物递送服务、体内程序培训和支持 用于议定书的准备和赠款的制定。 SASC由分子免疫学系教授David Colcher博士共同指导， 吴军博士，比较医学副研究教授，由高资质支持 维护和操作仪器的工作人员。监督由跨学科的教职员工咨询提供 委员会，并通过年度调查提供用户反馈。SASC占据了三个房间 2.9万平方英尺英国《金融时报》用于动物实验的Parvin大楼和亨廷顿实验室用于肿瘤细胞和试剂的两个房间 准备工作。ILab软件用于计划服务、监控仪器使用以及管理 SASC.在过去五年中，80名独立调查人员使用了SASC，其中包括58名CC成员。 在58个协调委员会成员中，48个(83%)获得了同行审查的资金。截至本报告，国资委正在提供 支持NIH资助的12个项目，每年为COHCCC带来总计560万美元的直接成本。