Molecular epidemiology of tick borne-emerging infectious disease, Anaplasmosis, Spotted fever, and Lyme borreliosis in East Asian countries.

东亚国家蜱传新发传染病、无形体病、斑疹热和莱姆疏螺旋体病的分子流行病学。

• 批准号: 23406012
• 负责人: MASUZAWA Toshiyuki
• 金额: $ 11.81万
• 依托单位: Chiba Institute of Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23406012/
• 关键词: アナプラズマ; ヒト顆粒球アナプラズマ症; ボレリア; ライム病; ダニ媒介性感染症; シュルツェマダニ; 紅斑熱; マダニ; マダニ媒介性感染症; リケッチア

The prevalence of human granulocytic anaplasmosis (HGA) agent, Anaplasma phagocytophilum and relapsing fever agent, Borrelia miyamotoi, in reservoir animals and vector ticks in East Asia, including Japan, were examined. Anaplasma was detected from Ixodes persulcatus ticks collected in Irkutsk, Khabarovsk, and Selenge in Mongolia. In Kochi Prefecture, Japan, two patients were confirmed retrospectively to be infected with Anaplasma and the agent detected was similar to those from ticks collected in far-east Russia. Relapsing fever-causing Borrelia was detected in ticks collected in Irkutsk and Khabarovsk, indicating that relapsing fever should be involved in the diagnosis of tick bite patients. Variant Anaplasma was detected in wild rodents captured in Taiwan. This agent has not been found in ticks collected in Taiwan and also China.Polysaccharide antigen extracted from spotted fever Rickettsia under alkaline condition could be used as antigen for Dot-ELISA-based serodiagnosis.

检查了东亚（包括日本）储畜和媒介蜱中人粒细胞无形体病（HGA）病原体（嗜吞噬细胞无形体）和回归热病原体（宫本疏螺旋体）的流行情况。从在蒙古伊尔库茨克、哈巴罗夫斯克和色楞格采集的全沟硬蜱中检测到无形体。在日本高知县，两名患者被回顾性证实感染了无形体，检测到的病原体与俄罗斯远东地区收集的蜱虫相似。在伊尔库茨克和哈巴罗夫斯克采集的蜱虫中检测到引起复发热的疏螺旋体，表明复发热应参与蜱虫叮咬患者的诊断。在台湾捕获的野生啮齿动物中发现了变异无形体。在碱性条件下从斑点热立克次体中提取多糖抗原，可作为斑点热立克次体血清学诊断的抗原。

项目成果

Tsutsugamushi disease caused by Shimokoshi-type Orientia tsutsugamushi: the first report in Western Japan.

• DOI: 10.4269/ajtmh.12-0740
• 发表时间: 2013-06
• 期刊: The American journal of tropical medicine and hygiene
• 作者: S. Ikegaya;H. Iwasaki;N. Takada;Seigo Yamamoto;T. Ueda

Detection and characterization of p44/msp2 transcript variants of Anaplasma phagocytophilum from naturally infected ticks and wild deer in Japan.

• DOI: 10.7883/yoken.65.79
• 发表时间: 2012-01
• 期刊: Japanese journal of infectious diseases
• 影响因子: 2.2
• 作者: Gaowa;Wuritu;Dongxing Wu;Y. Yoshikawa;N. Ohashi;F. Kawamori;K. Sugiyama;M. Ohtake;M. Ohashi-M.-Ohash

わが国でも問題のベクター媒介性感染症．8．日本紅斑熱の発生状況と媒介マダニから見えてくる感染環

媒介传播的传染病在日本也是一个问题。

• 发表时间: 2014
• 期刊: 化学療法の領域
• 作者: 下川周子;小林正規;千馬正敬;鈴江一友;平井誠;今井孝;谷口委代;久枝一;濱野真二郎;高田伸弘
• 通讯作者: 高田伸弘

Rickettsiae in ticks

蜱虫中的立克次体

• 发表时间: 2013
• 期刊: Japan. Emerg. Infect. Dis
• 作者: Gaowa;Ohashi;N.;Aochi;M.;Wuritu;Wu;D.;Yoshikawa;Y.;Kawamori;F.;Honda;T.;Fujita;H.;Takada;N.;Oikawa;Y.;Kawabata;H.;Ando;S.;and Kishimoto;T
• 通讯作者: T

シュルツェマダニ刺症で環状紅斑を呈したがライム病ボレリア感染は確認できない症例についての新たな見解

对舒尔茨蜱虫叮咬伴环形红斑病例的新见解，但未证实莱姆病伯氏疏螺旋体感染

• 发表时间: 2013
• 期刊: 衛生動物
• 作者: 夏秋優;高田伸弘;高嶋渉;熊切正信;川端寛樹;佐藤梢;高野愛
• 通讯作者: 高野愛