Optimizing Bilateral and Single-Sided Deafness Cochlear Implants for Functioning in Complex Auditory Environments

优化双侧和单侧耳聋人工耳蜗植入物以在复杂的听觉环境中发挥作用

• 批准号: 10065502
• 负责人: Joshua Gary Bernstein
• 金额: $ 36.75万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10065502
• 关键词: Acute; Adopted; Adoption; Auditory; Auditory system; Basic Science; Bilateral; Binaural; Bionics; Brain Stem; Clinical; Cochlea; Cochlear Implants; Communication; Complex; Data; Devices; Discrimination; Ear; Electric Stimulation; Electrodes; Electrophysiology (science); Environment; Equilibrium; Failure; Frequencies; Future; Goals; Hand; Hearing; Hour; Impairment; Implant; Individual; Intervention; Knowledge; Learning; Location; Longitudinal Studies; Maps; Measurement; Measures; Methods; Mission; National Institute on Deafness and Other Communication Disorders; Noise; Outcome; Patients; Pattern; Performance; Population; Public Health; Quality of life; Research; Sensory; Side; Sound Localization; Source; Speech; Stimulus; Technology; Testing; Time; Translational Research; United States National Institutes of Health; X-Ray Computed Tomography; base; clinical practice; deaf; deafness; disability; effective therapy; hard of hearing; hearing impairment; implantable device; improved; innovation; normal hearing; novel; programs; relating to nervous system; sound; speech in noise; standard of care; stem; tool; virtual

ABSTRACT: The vast majority of the roughly 100,000 cochlear-implant (CI) users have severe-to-profound hear- ing loss, but only receive a single CI in one ear. Yet, not having access to sound in two ears severely hampers the auditory systems' ability to overcome background noise, which has many consequences including increasing the amount of effort it takes to communicate. Even with access to sound in both ears, two-ear or “binaural” benefits for bilateral CI (BI-CI) and single-sided deaf CI (SSD-CI) users are small compared to normal-hearing listeners. Because of possible frequency mismatch between the two ears, it is unclear if the current standard approach of programming the CIs maximizes speech understanding for two ears, particularly in environments with multiple sound sources. Our long-term goal is to understand and maximize speech understanding and bin- aural benefits imparted by CIs by improving interaural frequency, level, and timing encoding. The next steps toward this goal and the objectives here are to evaluate interaural frequency mismatch and to develop novel CI programs (MAPs) to correct for mismatch. Our central hypothesis is that binaural function in BI-CI and SSD-CI users is suboptimal because of interaural frequency mismatch. Our approach will be to optimize the frequency- allocation in the poorer ear to minimize the mismatch and potentially improve speech understanding and spatial hearing. With strong preliminary data in hand, the central hypothesis will be tested by pursuing three specific aims: (1) Assess interaural frequency mismatch for individual electrodes in BI-CI and SSD-CI users. (2) Compare the acute functional benefits and limitations for the standard MAP and novel MAPs that minimize interaural fre- quency mismatch in BI-CI and SSD-CI users. (3) In a longitudinal study, evaluate the extent to which standard MAP and novel MAPs cause changes in pitch processing, binaural processing, and speech understanding in BI- CI and SSD-CI users. The expected outcome is improved binaural function for BI-CI and SSD-CI users, without sacrificing speech understanding. This research is significant because it will produce a positive impact in CI users' quality of life by improving communication in quiet and noisy environments. This proposal is innovative because it uses knowledge of binaural neural processing to provide a novel, non-invasive, and inexpensive method to reprogram CIs for bilateral hearing.

摘要：在大约100,000名人工耳蜗(CI)使用者中，绝大多数人有严重到深度的听力障碍。 ING丢失，但只在一只耳朵中收到一个CI。然而，无法在两只耳朵中听到声音严重阻碍了 听觉系统克服背景噪音的能力，这有许多后果，包括增加 沟通所需的努力程度。即使两只耳朵、两只耳朵或“双耳”都能听到声音 与听力正常相比，双侧CI(BI-CI)和单侧失聪CI(SSD-CI)使用者的益处很小 听众。由于两只耳朵之间可能存在频率不匹配，目前尚不清楚目前的标准 编程配置项的方法最大限度地提高了两只耳朵的语音理解能力，特别是在环境中。 具有多个音源。我们的长期目标是理解并最大限度地提高语音理解和绑定- CI通过改进耳间频率、电平和定时编码而赋予听觉上的好处。接下来的步骤 为了实现这一目标，本文的目的是评估耳间频率失配并开发新的CI 用于纠正不匹配的程序(地图)。我们的中心假设是BI-CI和SSD-CI的双耳功能 由于耳间频率不匹配，用户不是最优的。我们的方法将是优化频率- 在较差的耳朵中进行分配，以最大限度地减少失配，并潜在地改善语音理解和空间 听证。有了强大的初步数据，中心假设将通过追求三个具体的 目的：(1)评估BI-CI和SSD-CI使用者单个电极的耳间频率失配。(2)比较 对标准地形图和最大限度地减少耳间隔音的新地形图的急性功能优势和局限性进行了比较。 BI-CI和SSD-CI用户的频率不匹配。(3)在纵向研究中，评估标准的程度 MAP和新MAP导致BI中的基音处理、双耳处理和语音理解发生变化- CI和SSD-CI用户。预期结果是改善了BI-CI和SSD-CI用户的双耳功能，而不需要 牺牲了对语音的理解。这项研究具有重要的意义，因为它将对CI产生积极的影响 通过改善在安静和嘈杂环境中的交流，提高用户的生活质量。这个建议很有新意 因为它利用双耳神经处理的知识提供了一种新颖的、非侵入性的、廉价的 一种为双侧听证重新编程的方法。

项目成果

Dichotic listening performance with cochlear-implant simulations of ear asymmetry is consistent with difficulty ignoring clearer speech.

• DOI: 10.3758/s13414-021-02244-x
• 发表时间: 2021-07
• 期刊: Attention, perception & psychophysics
• 作者: Goupell MJ;Eisenberg D;DeRoy Milvae K
• 通讯作者: DeRoy Milvae K

Counting or discriminating the number of voices to assess binaural fusion with single-sided vocoders.

计算或区分声音的数量，以评估单侧声码器的双耳融合。

• DOI: 10.1121/10.0000511
• 发表时间: 2020
• 期刊: The Journal of the Acoustical Society of America
• 作者: Wess,JessicaM;Spencer,NathanielJ;Bernstein,JoshuaGW
• 通讯作者: Bernstein,JoshuaGW

Effect of experimentally introduced interaural frequency mismatch on sentence recognition in bilateral cochlear-implant listeners.

• DOI: 10.1121/10.0017705
• 发表时间: 2023-04-01
• 期刊: JASA EXPRESS LETTERS
• 影响因子: 1
• 作者: Cleary, Miranda;Milvae, Kristina DeRoy;Nguyen, Nicole;Bernstein, Joshua G. W.;Goupell, Matthew J.
• 通讯作者: Goupell, Matthew J.

Binaural Optimization of Cochlear Implants: Discarding Frequency Content Without Sacrificing Head-Shadow Benefit.

人工耳蜗的双耳优化：在不牺牲头影效果的情况下丢弃频率内容。

• DOI: 10.1097/aud.0000000000000784
• 发表时间: 2020
• 期刊: Ear and hearing
• 影响因子: 3.7
• 作者: Sheffield,SterlingW;Goupell,MatthewJ;Spencer,NathanielJ;Stakhovskaya,OlgaA;Bernstein,JoshuaGW
• 通讯作者: Bernstein,JoshuaGW

Computed-Tomography Estimates of Interaural Mismatch in Insertion Depth and Scalar Location in Bilateral Cochlear-Implant Users.

• DOI: 10.1097/mao.0000000000003538
• 发表时间: 2022-07-01
• 期刊: OTOLOGY & NEUROTOLOGY
• 影响因子: 2.1
• 作者: Goupell, Matthew J.;Noble, Jack H.;Phatak, Sandeep A.;Kolberg, Elizabeth;Cleary, Miranda;Stakhovskaya, Olga A.;Jensen, Kenneth K.;Hoa, Michael;Kim, Hung Jeffrey;Bernstein, Joshua G. W.
• 通讯作者: Bernstein, Joshua G. W.