New peptide-based drugs for the treatment of neuropathic pain

用于治疗神经性疼痛的新型肽类药物

• 批准号: nhmrc : 631457
• 负责人: Dr Richard Clark
• 金额: $ 35.15万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-peptide-based-neuropathic-pain/81005
• 关键词: New; peptide; based; drugs; treatment

Chronic pain affects 1 in 5 Australians and neuropathic pain is among the most severe forms of chronic pain. Peptides from cone snail venoms have attracted recent attention as potential therapeutic agents for the treatment of neuropathic pain. Unfortunately, these peptides suffer from the disadvantage of short biological half-lives and poor activity when taken orally. We have developed a new approach to solve these problems that we will apply to develop new drugs for the treatment of pain.

慢性疼痛影响五分之一的澳大利亚人，神经性疼痛是最严重的慢性疼痛形式之一。来自锥形蜗牛毒液的肽作为治疗神经性疼痛的潜在治疗剂最近引起了人们的关注。不幸的是，这些肽具有生物半衰期短和口服时活性差的缺点。我们已经开发了一种新的方法来解决这些问题，我们将应用于开发治疗疼痛的新药。