Understanding the structure/function relationships of the iron regulatory peptide hepcidin

了解铁调节肽铁调素的结构/功能关系

• 批准号: nhmrc : 1006423
• 负责人: Dr Richard Clark
• 金额: $ 24.35万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-structurefunction-relationships-peptide-hepcidin/109174
• 关键词: Understanding; structure; function; relationships; iron

This project seeks to understand the interactions between the peptide hormone hepcidin and its receptor and use this information to develop new drugs. Hepcidin is the major iron-regulatory hormone in humans and a range of iron-related diseases are caused by incorrect levels of this hormone. Many Australians are affected by these diseases so the development of hepcidin-based treatments has the potential to have significant impact on the overall health of the community.

该项目旨在了解肽激素hepcidin及其受体之间的相互作用，并利用这些信息开发新药。铁调素是人类主要的铁调节激素，一系列与铁有关的疾病是由这种激素的不正确水平引起的。许多澳大利亚人受到这些疾病的影响，因此基于hepcidin的治疗方法的发展有可能对社区的整体健康产生重大影响。