Integrative Genomics Approaches to Model the Genetic Architecture of Asthma
综合基因组学方法来模拟哮喘的遗传结构
基本信息
- 批准号:8955243
- 负责人:
- 金额:$ 16.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-11-01 至 2016-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
ABSTRACT
Asthma, a chronic respiratory disease affecting over 20 million Americans and 300 million people worldwide,
results from the complex interaction of multiple genetic and environmental factors. Many studies have
searched for individual genetic variants that contribute to asthma susceptibility, but a thorough understanding
of the genetic basis of asthma has not been achieved. Our main hypothesis is that the genetic architecture
underlying asthma susceptibility can be better understood by considering multiple genes and incorporating
multiple sources of genomic data, including human asthma and mouse airways hyperresponsiveness (AHR)
data. This hypothesis will be addressed via specific aims in which we will: (1) identify genetic variants that
predispose humans to asthma and modulate human AHR by mapping regions associated with AHR in inbred
strains of mice to human genome-wide association data, (2) use gene expression data, known protein-protein
interactions, and known functional pathways to enhance the search for asthma and AHR genetic variants in
humans, and (3) integrate individual human genetic variants to create a multivariate predictive model of
asthma. Novel variants identified by Specific Aims 1 and 2 will be validated by replication in independent
human populations of asthmatics. The predictive model created in Specific Aim 3 will be validated through
replication and prediction in independent human populations of asthmatics. By completing the specific aims,
we hope to make progress towards the development of a comprehensive model of the genetics of asthma,
particularly of asthma characterized by increased airways responsiveness.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Blanca E Himes其他文献
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{{ truncateString('Blanca E Himes', 18)}}的其他基金
Precision Approaches to Reduce Asthma Disparities with Electronic Health Record Data
利用电子健康记录数据减少哮喘差异的精确方法
- 批准号:
10540025 - 财政年份:2022
- 资助金额:
$ 16.34万 - 项目类别:
Precision Approaches to Reduce Asthma Disparities with Electronic Health Record Data
利用电子健康记录数据减少哮喘差异的精确方法
- 批准号:
10689250 - 财政年份:2022
- 资助金额:
$ 16.34万 - 项目类别:
CEBPD-Mediated Mechanisms of Glucocorticoid Insensitivity in Severe Asthma
CEBPD 介导的严重哮喘糖皮质激素不敏感机制
- 批准号:
9914313 - 财政年份:2017
- 资助金额:
$ 16.34万 - 项目类别:
Integrative Genomics Approaches to Model the Genetic Architecture of Asthma
综合基因组学方法模拟哮喘的遗传结构
- 批准号:
8847988 - 财政年份:2014
- 资助金额:
$ 16.34万 - 项目类别:
INTEGRATIVE GENOMICS APPROACHES TO MODEL THE GENETIC ARCHITECTURE OF ASTHMA
综合基因组学方法来模拟哮喘的遗传结构
- 批准号:
8724089 - 财政年份:2013
- 资助金额:
$ 16.34万 - 项目类别:
INTEGRATIVE GENOMICS APPROACHES TO MODEL THE GENETIC ARCHITECTURE OF ASTHMA
综合基因组学方法来模拟哮喘的遗传结构
- 批准号:
8727091 - 财政年份:2013
- 资助金额:
$ 16.34万 - 项目类别:
Translational Research Training Program in Environmental Health Sciences
环境健康科学转化研究培训计划
- 批准号:
10410778 - 财政年份:2012
- 资助金额:
$ 16.34万 - 项目类别:
Translational Research Training Program in Environmental Health Sciences
环境健康科学转化研究培训计划
- 批准号:
10636883 - 财政年份:2012
- 资助金额:
$ 16.34万 - 项目类别:
INTEGRATIVE GENOMICS APPROACHES TO MODEL THE GENETIC ARCHITECTURE OF ASTHMA
综合基因组学方法来模拟哮喘的遗传结构
- 批准号:
8299478 - 财政年份:2011
- 资助金额:
$ 16.34万 - 项目类别:
INTEGRATIVE GENOMICS APPROACHES TO MODEL THE GENETIC ARCHITECTURE OF ASTHMA
综合基因组学方法来模拟哮喘的遗传结构
- 批准号:
8189641 - 财政年份:2011
- 资助金额:
$ 16.34万 - 项目类别:
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Integrative Genomics Approaches to Model the Genetic Architecture of Asthma
综合基因组学方法模拟哮喘的遗传结构
- 批准号:
8847988 - 财政年份:2014
- 资助金额:
$ 16.34万 - 项目类别:
INTEGRATIVE GENOMICS APPROACHES TO MODEL THE GENETIC ARCHITECTURE OF ASTHMA
综合基因组学方法来模拟哮喘的遗传结构
- 批准号:
8724089 - 财政年份:2013
- 资助金额:
$ 16.34万 - 项目类别:
INTEGRATIVE GENOMICS APPROACHES TO MODEL THE GENETIC ARCHITECTURE OF ASTHMA
综合基因组学方法来模拟哮喘的遗传结构
- 批准号:
8727091 - 财政年份:2013
- 资助金额:
$ 16.34万 - 项目类别:
INTEGRATIVE GENOMICS APPROACHES TO MODEL THE GENETIC ARCHITECTURE OF ASTHMA
综合基因组学方法来模拟哮喘的遗传结构
- 批准号:
8299478 - 财政年份:2011
- 资助金额:
$ 16.34万 - 项目类别:
INTEGRATIVE GENOMICS APPROACHES TO MODEL THE GENETIC ARCHITECTURE OF ASTHMA
综合基因组学方法来模拟哮喘的遗传结构
- 批准号:
8189641 - 财政年份:2011
- 资助金额:
$ 16.34万 - 项目类别:














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