Translational Research Training Program in Environmental Health Sciences

环境健康科学转化研究培训计划

• 批准号: 10636883
• 负责人: Blanca E Himes
• 金额: $ 47.65万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10636883
• 关键词: Environmental Health; Training Programs; Translational Research

This application is the second competing continuation of a T32 Institutional Training Grant in Environmental Health Sciences (EHS) entitled: “Translational Research Training Program in EHS” (T32-ES019851) at the University of Pennsylvania (Penn). This training grant is the only dedicated mechanism to support formalized EHS research training at the pre- and post-doctoral level at Penn and meets a significant need based on trainee interest in the environment and its health impact and biomedical work force need. The mission of the T32 Training Program is to train the next generation of environmental health scientists to identify the mechanisms by which environmental exposures cause disease and to translate these findings into effective prevention and treatment and improvements in public health. The research training reflects the translational research themes of Penn’s P30 Environmental Health Sciences Core Center, the Center of Excellence in Environmental Toxicology (CEET). These themes include: Air Pollution and Lung Health, Environmental Exposures and Cancer, Windows of Susceptibility and Environmental Neuroscience. These themes are underpinned by exposure assessment, adverse outcomes, and translation to human subjects, communities and policy. Training is provided through course work from the Certificate Program in Environmental Health Sciences which includes a mandatory Community Environmental Health Rotation, by conducting a full- time translational research project co-mentored where possible by a basic-scientist and clinician-scientist to generate new knowledge in EHS. The 48 distinguished Training Grant (TG) faculty come from Penn and Children’s Hospital of Philadelphia, 22 are clinician-scientists and 21 are women. The TG supports common experiences including a research club, a dedicated seminar series, an annual symposium dedicated to a translational research theme, and optional externships at US EPA, the Silent Spring Institute, the Research Institute for Fragrance Materials and a Science Policy Institute so that trainees are exposed to alternative career options. The T32 award currently supports three predoctoral fellows to conduct dissertation research on an EHS topic and four postdoctoral fellows to perform mentored EHS research. Predoctoral trainees are supported for a total of three years (2nd year completion of the Certificate Program in EHS and two years dissertation research) and postdoctoral trainees are supported for two to three years. Trainees are prepared for a suite of careers in the employment sector e.g. academia (in EHS, Pharmacology and Toxicology), government agencies (e.g. US- EPA, CDC, FDA, NTP, NIEHS); and industry (drug, food, cosmetic and nanotechnology). In the last two cycles the Training Grant has supported 29 trainees, who have published 108 papers and alumni have continued with scientific careers in academia and industry. Since the last competitive renewal 38% of the trainees were underrepresented in science and 56% were women.

该申请是环境领域 T32 机构培训补助金的第二个竞争性延续 健康科学（EHS），题为：“EHS 转化研究培训计划”（T32-ES019851） 宾夕法尼亚大学（宾夕法尼亚大学）。该培训补助金是支持正规化的唯一专门机制 宾夕法尼亚大学博士前和博士后级别的 EHS 研究培训，满足受训者的重大需求 对环境及其健康影响的兴趣以及生物医学劳动力的需求。 T32的使命 培训计划旨在培训下一代环境健康科学家，以确定 环境暴露导致疾病的机制并将这些发现转化为 有效预防和治疗，改善公共卫生。研究培训体现了 宾夕法尼亚大学 P30 环境健康科学核心中心、该中心的转化研究主题 环境毒理学卓越奖 (CEET)。这些主题包括：空气污染和肺部健康， 环境暴露与癌症、易感性之窗和环境神经科学。这些 主题以暴露评估、不良后果和转化为人类受试者为基础， 社区和政策。培训通过环境证书课程的课程提供 健康科学，其中包括强制性的社区环境健康轮换，通过进行全面的 时间转化研究项目在可能的情况下由基础科学家和临床科学家共同指导 产生 EHS 方面的新知识。 48 名杰出的培训资助 (TG) 教师来自宾夕法尼亚大学和 费城儿童医院有 22 名临床医生科学家，其中 21 名是女性。 TG支持常见的 经验包括研究俱乐部、专门的研讨会系列、每年一次的研讨会 转化研究主题，以及可选的美国环保局、寂静之泉研究所、研究中心的实习机会 香料材料研究所和科学政策研究所，让学员有机会从事其他职业 选项。 T32 奖项目前支持三名博士前研究员进行 EHS 论文研究 主题和四名博士后研究员进行指导的 EHS 研究。博士前培训生获得支持 总共三年（第二年完成 EHS 证书课程和两年论文研究） 博士后实习生资助期限为二至三年。学员为一系列职业做好准备 就业部门，例如学术界（EHS、药理学和毒理学）、政府机构（例如美国- EPA、CDC、FDA、NTP、NIEHS）；和工业（药品、食品、化妆品和纳米技术）。最近两个周期 培训补助金已支持 29 名学员，他们发表了 108 篇论文，校友继续 学术界和工业界的科学事业。自上次竞争性更新以来，38% 的学员 科学领域的代表性不足，其中 56% 是女性。

项目成果

Characterization of a new N-terminally acetylated extra-mitochondrial isoform of frataxin in human erythrocytes.

• DOI: 10.1038/s41598-018-35346-y
• 发表时间: 2018-11-19
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Guo L;Wang Q;Weng L;Hauser LA;Strawser CJ;Mesaros C;Lynch DR;Blair IA
• 通讯作者: Blair IA

Global variation in gene expression and the value of diverse sampling.

• DOI: 10.1016/j.coisb.2016.12.018
• 发表时间: 2017-02
• 期刊: Current opinion in systems biology
• 影响因子: 3.7
• 作者: Kelly DE;Hansen MEB;Tishkoff SA
• 通讯作者: Tishkoff SA

Genetics and geography of leukocyte telomere length in sub-Saharan Africans.

• DOI: 10.1093/hmg/ddaa187
• 发表时间: 2020-11-04
• 期刊: Human molecular genetics
• 影响因子: 3.5
• 作者: Hunt SC;Hansen MEB;Verhulst S;McQuillan MA;Beggs W;Lai TP;Mokone GG;Mpoloka SW;Meskel DW;Belay G;Nyambo TB;Abnet CC;Yeager M;Chanock SJ;Province MA;Williams SM;Aviv A;Tishkoff SA
• 通讯作者: Tishkoff SA

Stable isotope dilution liquid chromatography/mass spectrometry analysis of cellular and tissue medium- and long-chain acyl-coenzyme A thioesters.

• DOI: 10.1002/rcm.6958
• 发表时间: 2014-08-30
• 期刊: RAPID COMMUNICATIONS IN MASS SPECTROMETRY
• 影响因子: 2
• 作者: Snyder, Nathaniel W.;Basu, Sankha S.;Zhou, Zinan;Worth, Andrew J.;Blair, Ian A.
• 通讯作者: Blair, Ian A.

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism.

人类血小板的 LC-MS 分析作为研究线粒体代谢的平台。

• DOI: 10.3791/53941
• 发表时间: 2016
• 期刊: Journal of visualized experiments : JoVE
• 作者: Worth,AndrewJ;Marchione,DylanM;Parry,RobertC;Wang,Qingqing;Gillespie,KevinP;Saillant,NoelleN;Sims,Carrie;Mesaros,Clementina;Snyder,NathanielW;Blair,IanA
• 通讯作者: Blair,IanA