Translational Research Training Program in Environmental Health Sciences

本申请是T32机构培训补助金在环境方面的第二个竞争延续 健康科学（EHS）题为：“EHS转化研究培训计划”（T32-ES 019851）， 宾夕法尼亚大学（Penn）这一培训补助金是唯一专门用于支持正规化培训的机制。 在宾夕法尼亚大学进行博士前和博士后水平的EHS研究培训，并满足学员的重大需求 对环境及其对健康的影响和生物医学劳动力需求的兴趣。T32的使命 培训计划旨在培养下一代环境卫生科学家， 环境暴露导致疾病的机制，并将这些发现转化为 有效预防和治疗以及改善公共卫生。研究培训反映了 宾夕法尼亚大学P30环境健康科学核心中心的翻译研究主题， 卓越环境毒理学（CEET）。这些主题包括：空气污染和肺部健康， 环境暴露与癌症，易感性窗口和环境神经科学。这些 主题由暴露评估、不良后果和对人类受试者的转化来支撑， 社区和政策。培训是通过环境认证课程提供的。 健康科学，其中包括一个强制性的社区环境卫生轮换，通过进行全面的- 在可能的情况下，由基础科学家和临床科学家共同指导时间转化研究项目， 在EHS方面产生新的知识。48名杰出的培训补助金（TG）教师来自宾夕法尼亚大学， 费城儿童医院，22名是临床科学家，21名是妇女。TG支持通用 经验包括一个研究俱乐部，一个专门的研讨会系列，一个专门讨论 翻译研究主题，并在美国环保署，寂静的春天研究所，研究 香料材料研究所和科学政策研究所，使受训人员有机会从事其他职业 选项. T32奖目前支持三名博士前研究员进行EHS论文研究 主题和四名博士后研究员进行指导EHS研究。博士前学员获得支持， 总共三年（第二年完成EHS证书课程和两年的论文研究） 对博士后研究生的资助时间为二至三年。学员们准备了一套职业生涯， 就业部门，如学术界（EHS、药理学和毒理学）、政府机构（如美国- EPA、CDC、FDA、NTP、NIEHS）;以及工业（药品、食品、化妆品和纳米技术）。在过去的两个周期中， 培训补助金资助了29名学员，他们发表了108篇论文，校友继续 学术界和工业界的科学事业。自上次竞争性续约以来， 在科学领域，妇女的比例不足，占56%。

This application is the second competing continuation of a T32 Institutional Training Grant in Environmental Health Sciences (EHS) entitled: “Translational Research Training Program in EHS” (T32-ES019851) at the University of Pennsylvania (Penn). This training grant is the only dedicated mechanism to support formalized EHS research training at the pre- and post-doctoral level at Penn and meets a significant need based on trainee interest in the environment and its health impact and biomedical work force need. The mission of the T32 Training Program is to train the next generation of environmental health scientists to identify the mechanisms by which environmental exposures cause disease and to translate these findings into effective prevention and treatment and improvements in public health. The research training reflects the translational research themes of Penn’s P30 Environmental Health Sciences Core Center, the Center of Excellence in Environmental Toxicology (CEET). These themes include: Air Pollution and Lung Health, Environmental Exposures and Cancer, Windows of Susceptibility and Environmental Neuroscience. These themes are underpinned by exposure assessment, adverse outcomes, and translation to human subjects, communities and policy. Training is provided through course work from the Certificate Program in Environmental Health Sciences which includes a mandatory Community Environmental Health Rotation, by conducting a full- time translational research project co-mentored where possible by a basic-scientist and clinician-scientist to generate new knowledge in EHS. The 48 distinguished Training Grant (TG) faculty come from Penn and Children’s Hospital of Philadelphia, 22 are clinician-scientists and 21 are women. The TG supports common experiences including a research club, a dedicated seminar series, an annual symposium dedicated to a translational research theme, and optional externships at US EPA, the Silent Spring Institute, the Research Institute for Fragrance Materials and a Science Policy Institute so that trainees are exposed to alternative career options. The T32 award currently supports three predoctoral fellows to conduct dissertation research on an EHS topic and four postdoctoral fellows to perform mentored EHS research. Predoctoral trainees are supported for a total of three years (2nd year completion of the Certificate Program in EHS and two years dissertation research) and postdoctoral trainees are supported for two to three years. Trainees are prepared for a suite of careers in the employment sector e.g. academia (in EHS, Pharmacology and Toxicology), government agencies (e.g. US- EPA, CDC, FDA, NTP, NIEHS); and industry (drug, food, cosmetic and nanotechnology). In the last two cycles the Training Grant has supported 29 trainees, who have published 108 papers and alumni have continued with scientific careers in academia and industry. Since the last competitive renewal 38% of the trainees were underrepresented in science and 56% were women.