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Center for Engineering Complex Tissues

复杂组织工程中心

基本信息

批准号：
10113608
负责人：
John P Fisher
金额：
$ 112.61万
依托单位：
UNIV OF MARYLAND, COLLEGE PARK
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-15 至 2023-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10113608
关键词：
3D Print Address Advisory Committees Area Award Back Biocompatible Materials Biomedical Engineering Biomedical Technology Bioreactors Bone Tissue Cardiac Cartilage Cell Culture Techniques Cell Survival Cells Cellularity Clinical Collaborations Communication Programs Communities Complex Development Device or Instrument Development Education Educational workshop Encapsulated Engineering Ensure Event Formulation Fostering Funding Goals Infrastructure Institution International Joints Lead Leadership Maryland Pattern Phase Population Positioning Attribute Productivity Property Publications Regenerative Medicine Research Research Personnel Resources Rice Series Services Technology Tissue Engineering Tissues Training Transplantation Universities Work base biofabrication bioprinting career clinically relevant experience forest implantation improved innovation knowledge base new technology next generation novel novel strategies operation osteochondral tissue outreach programs recruit scaffold sound success technology research and development tool undergraduate student urologic

项目摘要

Project Summary The fabrication of complex engineered tissues remains a grand challenge in regenerative medicine. These complex tissues – bone, cartilage, vasculature, and cardiac – are characterized by dense cellularity, patterned cellular composition, and controlled matrix presentation. The proposed Biomedical Technology Resource Center (BTRC) will address this critical need by applying three-dimensional printing (3DP) strategies to the engineering of complex tissues. This BTRC brings together research leaders at the University of Maryland, Rice University, and Wake Forest University, all highly regarded collaborators in the field, to lead the development of the Center for Engineering Complex Tissues (CECT, [sees-t]). Strong and effective administrative leadership will maximize productivity, enhance ongoing collaborations, and ensure sound fiscal and compliance management for this BTRC. The technical components of CECT consist of 3 Technology Research and Development Projects (TR&Ds), 6 Collaborative Projects (CPs), and 6 Service Projects (SPs). An External Advisory Committee (EAC), that will guide and advise the strategic direction of the Center, will be assembled from world-renowned researchers with biomedical expertise relevant to the CECT. A Local Executive Committee (LEC) will coordinate the effort across the participating institutions involved in the day-to- day operations of the Center. We will also focus on growing a community engaged in developing and utilizing complex engineered tissues by offering a series of programs to help develop and establish these technologies. Communications programs will also be developed for the dissemination of the Center’s activities to enable a broader use of the technologies. The long-term plan for the CECT is that it will become a national hub for transforming current 3DP and tissue engineering technologies into new and improved platforms for everyday uses in regenerative medicine and biomedical device development.

项目摘要制造复杂的工程组织仍然是再生医学的一个巨大挑战。这些复杂的组织--骨、软骨、脉管系统和心脏--以致密的细胞结构为特征，细胞组成和受控基质呈递。拟议的生物医学技术资源中心（BTRC）将通过将三维打印（3DP）策略应用于复杂组织的工程化。这个BTRC汇集了马里兰州大学的研究领导者，莱斯大学和维克森林大学都是该领域备受推崇的合作者，复杂组织工程中心（Center for Engineering Complex Tissues，CECT，[sees-t]）。坚强有力的行政领导将最大限度地提高生产力，加强持续的合作，并确保健全的财政以及该BTRC的合规管理。CECT的技术组成部分包括3项技术研究和开发项目（TR& D），6个合作项目（CP）和6个服务项目（SP）。一个外部咨询委员会（EAC）将为中心的战略方向提供指导和建议，由具有与CECT相关的生物医学专业知识的世界知名研究人员组成。本地执行委员会（LEC）将协调参与机构的日常工作，中心的日常运作。我们还将专注于发展一个从事开发和利用通过提供一系列项目来帮助开发和建立这些技术，还将制定传播方案，宣传中心的活动，更广泛地使用这些技术。CECT的长期计划是，它将成为一个国家中心，将当前的3DP和组织工程技术转变为新的和改进的日常平台用于再生医学和生物医学设备开发。

项目成果

期刊论文数量（115）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The Evolution of Polystyrene as a Cell Culture Material.

DOI：
10.1089/ten.teb.2018.0056
发表时间：
2018-10
期刊：
Tissue engineering. Part B, Reviews
影响因子：
0
作者：
Lerman MJ;Lembong J;Muramoto S;Gillen G;Fisher JP
通讯作者：
Fisher JP

The Role of the Microenvironment in Controlling the Fate of Bioprinted Stem Cells.

DOI：
10.1021/acs.chemrev.0c00126
发表时间：
2020-10-14
期刊：
Chemical reviews
影响因子：
62.1
作者：
West-Livingston LN;Park J;Lee SJ;Atala A;Yoo JJ
通讯作者：
Yoo JJ

The effect of BMP-mimetic peptide tethering bioinks on the differentiation of dental pulp stem cells (DPSCs) in 3D bioprinted dental constructs.

DOI：
10.1088/1758-5090/ab9492
发表时间：
2020-07-01
期刊：
Biofabrication
影响因子：
9
作者：
Park JH;Gillispie GJ;Copus JS;Zhang W;Atala A;Yoo JJ;Yelick PC;Lee SJ
通讯作者：
Lee SJ

The Influence of Printing Parameters and Cell Density on Bioink Printing Outcomes.

DOI：
10.1089/ten.tea.2020.0210
发表时间：
2020-12
期刊：
Tissue engineering. Part A
影响因子：
0
作者：
Gillispie GJ;Han A;Uzun-Per M;Fisher J;Mikos AG;Niazi MKK;Yoo JJ;Lee SJ;Atala A
通讯作者：
Atala A

Extrusion-based 3D printing of poly(propylene fumarate) scaffolds with hydroxyapatite gradients.