Molecular Genomics Core
Molecular Genomics Core
批准号:
10115671
负责人:
Alvaro N Monteiro
金额:
$11.8万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-02-18 至 2022-01-31
关键词:
Applications GrantsAreaAutomationAutomobile DrivingBackBase SequenceBiologicalBudgetsCancer CenterCancer Center Support GrantCell LineChIP-seqChromatinChronic Myelomonocytic LeukemiaClinicClinicalClinical TrialsConsultationsContractsCopy Number PolymorphismCustomDNADNA Sequence AlterationDNA sequencingDataDevelopmentDideoxy Chain Termination DNA SequencingDocumentationEducationEpidemiologyEpigenetic ProcessExperimental DesignsFundingFutureGene ExpressionGenerationsGenetic VariationGenomic approachGenomicsGenotypeGoalsHigh-Throughput Nucleotide SequencingImmunoglobulin Variable RegionIndividualInformaticsInstitutional Review BoardsIonsLaboratoriesLeadLettersLinkMalignant NeoplasmsMassive Parallel SequencingMediationMessenger RNAMethylationModelingModernizationMolecularMolecular TargetMultiple MyelomaNeoplasm Circulating CellsPatient CarePatientsPeer ReviewPerformancePositioning AttributePostdoctoral FellowPricePublicationsResearchResearch PersonnelRiskSamplingScienceScientistServicesSingle Nucleotide PolymorphismSmall RNATimeTissuesTumor TissueVendorWood materialWorkanticancer researchbasecancer genomicscancer initiationcancer predispositioncohortcomputerized data processingcost estimatedigitaldisorder riskdoctoral studentexomeexome sequencingexperienceimprovedimproved outcomeinterestmembernano-stringnew technologynovel strategiespersonalized approachprecision medicineprogramsresponsesequencing platformservice membersingle cell analysistargeted exome sequencingtargeted sequencingtranscriptome sequencingtumortumor DNAtumor progression
中文摘要
项目总结
分子基因组学核心(MGC)的总体目标是促进莫菲特癌症中心的研究
(MCC)通过提供最先进的、及时的、具有竞争力的高质量基因组学服务。
MGC有三个具体目标,以教育、咨询和服务为中心。MGC的可持续性
该模型的基础是促进基因组学技术方面的教育,从而培养人们对它们的使用兴趣
回答特定的科学问题。然后,MGC为成员提供免费咨询,以完善实验
设计和支持赠款申请。这些组成部分导致资助的赠款申请进一步推动
需求。MGC有三个目标:1)为成员提供具体的实验设计咨询;2)
向会员提供高质量的分子基因组学服务;3)向会员提供高质量的基因组学教育。
MGC由六名全职工作人员组成,提供以下服务:完整外显子组和靶向DNA
测序,mRNA和小RNA-序列,芯片-序列,定量聚合酶链式反应,桑格测序,细胞系
鉴定、纳米串计数器分析和微阵列服务,包括表达、单核苷酸
使用各种平台的多态(SNPs)、拷贝数变异(CNV)和甲基化阵列。
MGC通过为以下成员开发和提供尖端服务,对MCC产生了重大影响
注重促进精准医疗造福患者。MGC与TC和CIC密切合作
提供样品采集、数据生成和分析的无缝集成。MGC的影响是
MGC支持的包括临床和分子数据在内的顶级出版物的数量就是例证,
例如Koomen博士的免疫球蛋白可变区大规模并行测序的新方法
在多发性骨髓瘤患者中(Remly-Wood,2014)和Eric Padron博士对慢性
分子水平的粒单核细胞白血病队列(Padron,2014)。
为回应先前的检讨,该局对其改善服务的目标作出重大调整。
针对成员,并采用新技术,如靶向和外显子组测序,RNA和芯片-
SEQ、纳米串和细胞系认证。因此,MGC的收入比过去增加了293%
资金周期,MGC被所有五个计划的成员大量使用。在最近一个财政年度
去年,MGC为MCC成员提供了服务,同行评议资助的成员使用了88%的资源。
英文摘要
PROJECT SUMMARY
The overall goal of the Molecular Genomics Core (MGC) is to facilitate research at the Moffitt Cancer Center
(MCC) by providing high-quality genomics services that are state-of-the-art, timely, and competitively priced.
The MGC has three specific aims centered on education, consultations, and services. MGC's sustainability
model is based on promoting education in technological aspects of genomics, which builds interest in their use
to answer specific scientific questions. The MGC then offers members free consultations to refine experimental
design and to support grant applications. These components lead to funded grant applications further driving
demand. The MGC has three aims, to provide: 1) specific experimental design consultations to members; 2)
high-quality molecular genomics services to members; and 3) high-quality genomics education to members.
The MGC comprises six full-time staff and provides the following services: whole exome and targeted DNA
sequencing, mRNA and small RNA-Seq, ChIP-seq, quantitative PCR, Sanger sequencing, cell line
authentication, NanoString nCounter analysis, and microarray services including expression, single nucleotide
polymorphisms (SNPs), copy number variants (CNV), and methylation arrays using a variety of platforms.
The MGC has a major impact on the MCC by developing and providing cutting-edge services to members with
a focus on facilitating precision medicine to benefit patients. The MGC works closely with the TC and the CIC
to provide seamless integration of sample acquisition, data generation, and analysis. The impact of the MGC is
exemplified by the number of MGC-supported top-tier publications that include clinical and molecular data,
such as Dr. Koomen's novel approach of massively parallel sequencing of the immunoglobulin variable regions
in multiple myeloma patients (Remily-Wood, 2014) and Dr. Eric Padron's characterization of a chronic
myelomonocytic leukemia cohort at the molecular level (Padron, 2014).
In response to the prior review, the MGC underwent a significant realignment of its aims to improve services
for members and to incorporate new technologies such as targeted and exome sequencing, RNA- and ChIP-
Seq, NanoString and cell line authentication. As a result, MGC revenues increased by 293% over the past
funding cycle, and the MGC is heavily used by members from all five programs. During the most recent fiscal
year, the MGC served 64 MCC members, with 88% of total utilization by peer-review-funded members.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
RESISTANCE AND RESPONSE SIGNALING TO PARP1 INHIBITORS IN OVARIAN CANCER
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批准号:10197460
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项目类别:
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资助金额:$23.1万
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财政年份:2021
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负责人:Alvaro N Monteiro
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依托单位:
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批准号:7216498
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批准号:7045977
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项目类别:
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资助金额:$22.68万
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财政年份:2004
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资助金额:$23.23万
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批准号:6740929
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项目类别:
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资助金额:$23.23万
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财政年份:2004
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批准号:7125859
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项目类别:
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资助金额:$4.77万
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财政年份:2004
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负责人:Alvaro N Monteiro
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依托单位:
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批准号:6472416
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项目类别:
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资助金额:$26.77万
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财政年份:2002
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批准号:6624114
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项目类别:
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资助金额:$26.77万
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财政年份:2002
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负责人:Alvaro N Monteiro
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依托单位:
Molecular Genomics Core
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批准号:10333179
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项目类别:
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资助金额:$16.22万
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财政年份:1998
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负责人:Alvaro N Monteiro
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依托单位:
Molecular Genomics Core
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批准号:10558785
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项目类别:
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资助金额:$0.0万
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财政年份:1998
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负责人:Alvaro N Monteiro
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依托单位:
Molecular Genomics Core
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批准号:10230153
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项目类别:
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资助金额:$0.45万
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财政年份:1998
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负责人:Alvaro N Monteiro
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依托单位:
Molecular Genomics Core
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批准号:9209819
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项目类别:
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资助金额:$11.67万
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财政年份:--
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负责人:Alvaro N Monteiro
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依托单位:
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批准号:9419800
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项目类别:
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资助金额:$11.67万
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财政年份:--
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负责人:Alvaro N Monteiro
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依托单位:
国内基金
海外基金
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批准号:2021JJ40433
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资助金额:--
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负责人:孙磊
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依托单位:
寄主诱导梢腐病菌AreA和CYP51基因沉默增强甘蔗抗病性机制解析
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批准年份:2020
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依托单位:
AREA国际经济模型的移植.改进和应用
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批准年份:1988
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负责人:史树中
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依托单位: