Translating Measures of Visual Experience to Children with Autism and Down Syndrome

项目总结/摘要 背景：印第安纳州临床和转化科学研究所（CTSI）有一个持续的记录， 通过职业发展，教育和研究培训培训KL 2学者的成就 （CERT）程序。KL 2学者从该州的三所主要研究型大学招募：印第安纳州 大学，普渡大学和圣母大学，这丰富了他们的经验，并扩大 翻译研究的广度。该印第安纳州CTSI是独特的定位，也扩大研究和 培训机会，包括与唐氏综合症（DS）有关的培训。职业目标：我的长期职业生涯 我们的目标是建立一个转化研究计划，整合从基础研究的见解，在典型的， 非典型的发展和知识的利益相关者在社区发展衡量 改进干预措施的交付和实施的技术。本报告的总体目标 应用程序正在朝着这个目标前进，通过确定家庭内的实时视觉体验是否 学习情境可能是一种有效的新的结果测量工具。研究项目：儿童 唐氏综合征（DS）具有表现为语言发育延迟的行为表型， 影响生活的方方面面。虽然自闭症谱系障碍（自闭症）儿童的典型特征是 他们的行为表型非常不同，常常表现为语言迟缓。尽管努力 在制定新的有效干预措施方面，进展缓慢，部分原因是测量工具的问题。 视觉采样的动态方面严重影响了语言学习的过程，在典型的发展中国家， 孩子这项研究的目的是确定如何实时视觉体验（即， 抽样）在家庭学习环境中影响发育迟缓儿童的语言学习， 第一步是确定视觉体验是否有潜力作为一种新的结果衡量标准。完成 为了实现这一目标，患有DS的儿童，患有自闭症的儿童，以及通常发育中的同龄人将佩戴头戴式摄像机， 他们的家在日常活动中。视频将被编码为视觉采样模式。职业生涯 发展：KL 2机构职业发展奖的行政补充将提供 开展独立研究所需的必要培训，其中包括关注儿童 在DS培训活动包括：DS的沉浸式临床体验，收集的高级培训， 处理和分析视觉体验数据，并继续专业发展。导师：安 来自印第安纳州CTSI网络内各机构的跨学科团队支持培训活动， 本培训计划：琳达史密斯博士（印第安纳州大学，布卢明顿），玛丽莲布尔博士（印第安纳州大学， 医学院）、Mandy Rispoli博士（普渡大学）和Chen Yu博士（印第安纳州大学， 布卢明顿）。

PROJECT SUMMARY/ABSTRACT Background: The Indiana Clinical and Translational Sciences Institute (CTSI) has a sustained record of accomplishment of training KL2 Scholars through its Career development, Education and Research Training (CERT) Program. KL2 scholars are recruited from the 3 major research universities in the state: Indiana University, Purdue University, and the University of Notre Dame, which enriches their experience and expands the breadth of translational research. The Indiana CTSI is uniquely positioned to also expand research and training opportunities to include training related to Down syndrome (DS). Career Goals: My long-term career goal is to build a translational research program that integrates insights from basic research in both typical and atypical development and knowledge from the stakeholders in the community to develop measurement techniques that improve the delivery and implementation of interventions. The overall objective of this application is progress towards that goal by determining whether real-time visual experience within home learning contexts is potentially an effective new outcome measurement tool. Research Project: Children with Down syndrome (DS) have a behavioral phenotype that presents with delays in language development that impact all aspects of life. Although children with Autism Spectrum Disorder (autism) are typically characterized with a very different behavioral phenotype, they too often present with language delays. Despite efforts to develop new, effective interventions, progress has been slowed in part due to issues with measurement tools. Dynamic aspects of visual sampling heavily impact the process of language learning in typically developing children. The objective for this research proposal is to determine how real-time visual experience (i.e. sampling) within home learning contexts impacts language learning for children with developmental delays as a first step in determining whether visual experience has potential as a new outcome measure. To accomplish this goal, children with DS, with autism, and typically developing peers will wear head-mounted cameras in their home during regular daily activities. Videos will be coded for patterns of visual sampling. Career Development: This Administrative Supplement to the KL2 Institutional Career Development Award will provide the necessary training required to launch an independent research career that includes a focus on children with DS. Training activities include: immersive clinical experience with DS, advanced training in the collection, processing, and analysis of visual experience data, and continued professional development. Mentorship: An interdisciplinary team from across institutions within the Indiana CTSI network supports training activities within this training plan: Dr. Linda Smith (Indiana University, Bloomington), Dr. Marilyn Bull (Indiana University, School of Medicine), Dr. Mandy Rispoli (Purdue University), and Dr. Chen Yu (Indiana University, Bloomington).