Clinical Impact of Respiratory-Swallow Training on Refractory Dysphagia in OP HNC

呼吸吞咽训练对 OP HNC 难治性吞咽困难的临床影响

• 批准号: 10084171
• 负责人: BONNIE J MARTIN-HARRIS
• 金额: --
• 依托单位: EDWARD HINES JR VA HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10084171
• 关键词: Ablation; Adherence; Adjuvant; Area; Aspiration Pneumonia; Barium swallow; Behavioral; Big Data; Chronic; Clinic; Clinical; Clinical assessments; Computer Analysis; Computer software; Crossover Design; Data; Databases; Deglutition; Deglutition Disorders; Development; Diet; Disease; Eating; Educational Intervention; Elements; Enteral Feeding; Event; Food; Future; General Population; Generations; Goals; Head and Neck Cancer; Health; Health care facility; Home; Impairment; Incidence; Infection; Ingestion; Intake; Intervention; Knowledge; Laboratories; Larynx; Learning; Life; Liquid substance; Maintenance; Malignant Neoplasms; Measurement; Measures; Mechanics; Medical; Methods; Modeling; Motor; Operative Surgical Procedures; Oral; Oropharyngeal; Outcome; Outcome Measure; Patient Care; Patients; Pattern; Penetration; Personal Satisfaction; Pharyngeal structure; Phase; Physiological; Physiology; Public Health Informatics; Quality of life; Randomized; Refractory; Rehabilitation therapy; Reporting; Reproducibility; Research; Resistance; Respiration; Risk; Science; Services; Site; Standardization; System; Testing; Texture; Toxic effect; Training; Translations; Veterans; active method; arm; cancer care; cancer therapy; care burden; care coordination; clinical application; clinical efficacy; clinical practice; clinical translation; clinically relevant; compliance behavior; cost; design; drinking; feasibility testing; functional improvement; functional outcomes; improved; innovation; intervention effect; mobile computing; novel; patient population; primary outcome; programs; prototype; recruit; rehabilitative care; respiratory; response; secondary endpoint; standard of care; tongue root; treatment arm

Despite important advancements in medical and surgical cancer treatments that prolong survival, veterans with oropharyngeal head and neck cancer (OP HNC) are faced with chronic, intractable dysphagia resulting in persistent drastic alterations in diet, the need for feeding tubes, and increased risk for aspiration pneumonia – a life threatening infection. We must devote research and clinical efforts to mitigate these devastating impairments because currently our rehabilitative intervention options are severely limited. As such, and in keeping with the VHA’s Blueprint for Excellence Transformative Actions, the need for the development of effective swallowing interventions that show potential for rapid translation to clinical practice is imperative. Respiratory-swallow coordination is an essential element of airway protection during swallowing and facilitates many key aspects of swallowing physiology. This key coordinative event is significantly disrupted in patients who are dysphagic following medical and surgical treatments for OP HNC. [Our preliminary trial tested an innovative swallowing treatment approach developed in our clinical laboratory, respiratory-swallow training (RST), that targets respiratory-swallow coordination directly and resulted in compelling improvements in physiologic swallowing outcomes in veterans suffering from dysphagia that persisted long after traditional behavioral swallowing intervention(s). The goal of this proposed trial is to extend our preliminary study using a rigorous, randomized cross over design and determine the impact and durability of RST on clinical outcomes essential for eating, drinking, health, and quality-of-life in veterans with OP HNC. As such, positive results from the proposed trial have high significance and clinical relevance for veterans’ health and well-being.] A total of 88 subjects will be recruited and randomly assigned 1:1 to either RST (intervention arm) or no active treatment (control arm), which is considered standard of care in this patient population. Data obtained will be used to evaluate clinical efficacy and durability. Data obtained from [an additional 11] subjects randomized to RST + home practice (HP) will be used to assess the feasibility of adjuvant HP program and to obtain preliminary data on its added impact on efficacy and response durability. The primary efficacy endpoint is Functional Oral Intake Scale level, and the secondary endpoint will be respiratory-swallow phase patterning. We will also elaborate on the impact of RST by detailing the physiological, airway protective, and morphometric changes that occur. We will use reproducible, reliable, and validated metrics that include the Modified Barium Swallow Impairment Profile, Penetration-Aspiration Scale, and Computational Analysis of Swallowing Mechanics to distinguish the mechanistic effects of RST. Further, adherence to a novel HP component using self-guided practice will be introduced and tested for feasibility and contribution to the degree and durability of the RST intervention effect. Our overarching goal is to provide two parallel tracks of knowledge generation: 1) provide immediate clinical translation of experimental findings to improve the lives of veterans, and 2) drive model generation on fundamental mechanisms of motor coordination. Basic knowledge will drive clinical application and vice-a- versa. As such, this is an ideal experimental and clinical context that will fuel knowledge generation in this highly significant area of science and clinical practice.

尽管医学和外科癌症治疗取得了重大进展，延长了生存期，但退伍军人