Research and Mentoring on Swallowing Impairment and Respiratory-Swallow Coordinat

描述（由申请人提供）：导师制是学术医学职业发展的一个组成部分。还迫切需要在吞咽困难领域指导和培养下一代职业科学家，这是一种对患者健康和生活质量造成沉重负担的普遍疾病。候选人建议增加POR研究人员和团队科学家在吞咽障碍和吞咽相互作用，重点是发现客观评估和循证的新方法，有针对性的干预措施，加快整个疾病或病症过程中的恢复，并促进最佳结果。研究和职业发展将在导师结构中进行，该结构为成功的患者导向研究人员提供支持环境，这些研究人员在吞咽和吞咽障碍研究中过渡到学术生涯的早期阶段。这些机会，在一定程度上，将来自候选人自己提出的研究计划和合作。该研究计划的主要目的是使用候选人开发的交钥匙、标准化、有效和可靠的测量和数据存储方法以及新型统计映射技术，开发在三种具有高发病率和吞咽障碍相关负担的患者疾病（肺癌、神经癌、头颈癌）中表达的吞咽障碍表型。次要目的是证明吞咽协调模式、气道保护与吞咽障碍的性质和严重程度之间的联系。这项研究的长期目标是开发预测模型（统计和动态），使临床医生能够在吞咽困难相关疾病或病症的早期阶段凭经验预测吞咽障碍的类型，严重程度和治疗反应性。

DESCRIPTION (provided by applicant): Mentorship is an integral component of career advancement in academic medicine. There is also an acute need to mentor and nurture the next generation of career scientists in the area of dysphagia, a prevalent condition that places high burden on patient health and quality of life. The candidate proposes to increase the cadre of POR researchers and team scientists in swallowing disorders and respiratory-swallowing interactions with emphasis on discovery of novel methods of objective assessment and evidence-based, targeted interventions that hasten recovery across the course of a disease or condition and facilitate optimal outcomes. Research and career development will take place in a mentorship structure that provides an environment of support for successful patient oriented researchers transitioning into the early stages of academic careers in the study of swallowing and respiratory-swallowing impairment. These opportunities, in part, will arise from the candidate's own proposed research plan and collaborations. The primary objective of the research plan is to develop swallowing impairment phenotypes that express in three patient conditions with high morbidity and burden related to swallowing impairment (pulmonary, neurologic, head and neck cancer) using turn-key, standardized, valid and reliable measurement and data storage methods, developed by the candidate, and novel statistical mapping techniques. The secondary objective is to demonstrate a link between respiratory-swallow coordination pattern, airway protection, and the nature and severity of swallowing impairment. The long-term goal of this research is to develop prediction models (statistical and dynamic) that will enable clinicians to empirically predict type, severity, and treatment responsiveness of swallowing impairment at early stages of the dysphagia-related disease or condition.