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Research and Mentoring on Swallowing Impairment and Respiratory-Swallow Coordinat

吞咽障碍和呼吸-吞咽协调的研究和指导

基本信息

批准号：
8600265
负责人：
BONNIE J MARTIN-HARRIS
金额：
$ 17.93万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-01-01 至 2017-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8600265
关键词：
3-Dimensional Acute Area Center for Translational Science Activities Clinical Clinical Research Clinical Sciences Collaborations Data Storage and Retrieval Deglutition Deglutition Disorders Development Discipline Disease Doctor of Philosophy Economic Burden Engineering Environment Evaluation Faculty Future Goals Grant Head and Neck Cancer Head and Neck Surgery Head and neck structure Health Health Sciences Impairment Institute of Medicine (U.S.)Institution Intervention Lead Leadership Life Link Longevity Lung Maps Measurement Medicine Mentors Mentorship Methodology Methods Mid-Career Clinical Scientist Award (K24)Minority Modeling Morbidity - disease rate Nature Neurologic Operative Surgical Procedures Otolaryngology Outcome Pathway interactions Patients Pattern Phenotype Positioning Attribute Postdoctoral Fellow Productivity Publications Quality of life Recording of previous events Recovery Research Research Ethics Research Personnel Role Scientist Severities Simulate Staging Statistical Models Structure Surgeon Techniques Time Training Translations Trauma Woman career career development clinical practice clinically relevant doctoral student evidence base interest intervention effect member next generation novel patient oriented patient oriented research pre-doctoral predictive modeling programs public health relevance rehabilitation science research and development respiratory skills systematic review

项目摘要

DESCRIPTION (provided by applicant): Mentorship is an integral component of career advancement in academic medicine. There is also an acute need to mentor and nurture the next generation of career scientists in the area of dysphagia, a prevalent condition that places high burden on patient health and quality of life. The candidate proposes to increase the cadre of POR researchers and team scientists in swallowing disorders and respiratory-swallowing interactions with emphasis on discovery of novel methods of objective assessment and evidence-based, targeted interventions that hasten recovery across the course of a disease or condition and facilitate optimal outcomes. Research and career development will take place in a mentorship structure that provides an environment of support for successful patient oriented researchers transitioning into the early stages of academic careers in the study of swallowing and respiratory-swallowing impairment. These opportunities, in part, will arise from the candidate's own proposed research plan and collaborations. The primary objective of the research plan is to develop swallowing impairment phenotypes that express in three patient conditions with high morbidity and burden related to swallowing impairment (pulmonary, neurologic, head and neck cancer) using turn-key, standardized, valid and reliable measurement and data storage methods, developed by the candidate, and novel statistical mapping techniques. The secondary objective is to demonstrate a link between respiratory-swallow coordination pattern, airway protection, and the nature and severity of swallowing impairment. The long-term goal of this research is to develop prediction models (statistical and dynamic) that will enable clinicians to empirically predict type, severity, and treatment responsiveness of swallowing impairment at early stages of the dysphagia-related disease or condition.

描述(由申请者提供)：导师是学术医学职业发展不可或缺的组成部分。还迫切需要在吞咽困难领域指导和培养下一代职业科学家，吞咽困难是一种给患者健康和生活质量带来沉重负担的普遍情况。候选人建议增加POR研究人员和团队科学家在吞咽障碍和呼吸吞咽互动方面的干部，重点是发现客观评估和基于证据的有针对性的干预措施的新方法，以加速疾病或疾病的整个过程的康复，并促进最佳结果。研究和职业发展将在导师结构中进行，为成功的以患者为导向的研究人员过渡到吞咽和呼吸吞咽损伤研究的学术生涯早期阶段提供支持环境。这些机会在一定程度上将来自候选人自己提出的研究计划和合作。研究计划的主要目标是利用候选人开发的交钥匙、标准化、有效和可靠的测量和数据存储方法以及新的统计映射技术，开发在与吞咽障碍(肺、神经、头颈部癌症)相关的高发病率和负担的三种患者情况下表现出来的吞咽障碍表型。第二个目标是证明呼吸-吞咽协调模式、呼吸道保护和吞咽损害的性质和严重程度之间的联系。这项研究的长期目标是开发预测模型(统计和动态)，使临床医生能够经验性地预测吞咽障碍相关疾病或状况早期阶段吞咽障碍的类型、严重程度和治疗反应。