Longitudinal Examination of Sluggish Cognitive Tempo and Internalizing Psychopathology in Adolescence

青春期迟缓认知节奏和内化精神病理学的纵向检查

• 批准号: 10117644
• 负责人: Stephen P Becker
• 金额: $ 76.28万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2025-10-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10117644
• 关键词: Accounting; Address; Adolescence; Adolescent; Advanced Development; Age; Anxiety; Attention deficit hyperactivity disorder; Behavioral; Behavioral Symptoms; Behavioral inhibition; Biological; Child; Clinical; Clinical Treatment; Clinical assessments; Cognitive; Communities; Complex; Confusion; Cross-Sectional Studies; Data; Daydreams; Development; Dimensions; Failure; Feeling suicidal; Fibrinogen; Goals; Link; Loneliness; Measures; Mediating; Mental Depression; Methods; Modeling; National Institute of Mental Health; Outcome; Parents; Participant; Patient Self-Report; Physiological; Positioning Attribute; Psychopathology; Punishment; Research; Research Domain Criteria; Sampling; School-Age Population; Self Efficacy; Social Environment; Suicide; Sum; Sympathetic Nervous System; Symptoms; System; Temperament; Testing; Theoretical model; Thinking; Time; Withdrawal; Youth; associated symptom; base; cognitive change; cognitive process; design; early adolescence; functional disability; informant; peer; prospective; recruit; social; suicidal risk; symptomatology; teacher

PROJECT SUMMARY/ABSTRACT Sluggish cognitive tempo (SCT) is a set of behavioral symptoms characterized by excessive daydreaming, slowed thinking, and mental confusion and fogginess. It is now established that SCT can be reliably measured across parent, teacher, and self-report ratings and is distinct from other psychopathology dimensions including ADHD and internalizing symptoms. A rapidly growing body of research also demonstrates SCT to be strongly associated with functional impairment, above and beyond other psychopathologies. However, SCT remains absent from current models of psychopathology, in large part because the field lacks rigorous longitudinal research examining SCT in relation to other psychopathologies. In cross-sectional studies, SCT symptoms are consistently and strongly associated with internalizing symptoms. Preliminary findings also document associations between SCT and increased suicide risk. Importantly, our pilot data show SCT predicts increased internalizing symptoms rather than the reverse. Further, SCT symptoms uniquely predict internalizing problems and not externalizing behaviors, suggesting that SCT may be a unique factor in understanding the development of internalizing problems specifically. Yet studies linking SCT to internalizing symptoms in youth are limited in several ways, including: (a) use of cross-sectional designs that preclude establishment of temporal associations, (b) using convenience samples (e.g., ADHD) rather than a sample enriched for SCT specifically, (c) failing to examine possible mechanisms or vulnerabilities linking SCT to internalizing symptoms, and (d) focusing on school-aged children even though SCT symptoms and internalizing problems sharply increase in adolescence. This study will address these limitations by using a prospective longitudinal, multi-informant, multi-method design across the developmentally sensitive period of early adolescence to examine SCT symptoms as a predictor of diverse internalizing outcomes and to test mechanisms and vulnerabilities linking SCT to internalizing symptoms in a community sample enriched for SCT symptomatology. Specifically, a community-based sample of 330 young adolescents (ages 10-12 years) enriched for SCT symptomatology will be recruited and assessed at three timepoints one year apart. Consistent with the NIMH Research Domain Criteria (RDoC) initiative and a developmental psychopathology framework, a multi-informant, multi-method battery that cuts across physiological, behavioral, and self-report units of analysis will be used. We will examine dimensional SCT symptoms as a predictor of internalizing psychopathology change over time, test mechanisms of the longitudinal relation between SCT and internalizing psychopathologies, and explore vulnerabilities (physiological reactivity, punishment sensitivity) that exacerbate these longitudinal relations. Findings establishing longitudinal effects and identifying mechanisms and vulnerabilities that cut across units of analysis will advance the development of theoretical models of SCT. Findings from this study will also provide avenues for targeted clinical assessment and treatment.

项目概要/摘要 认知节奏迟缓 (SCT) 是一组以过度白日梦为特征的行为症状， 思维迟缓，精神混乱和模糊。现已确定 SCT 可以可靠地测量 跨越家长、老师和自我报告的评分，与其他精神病理学维度不同，包括 多动症和内化症状。快速增长的研究也表明 SCT 具有很强的 与功能障碍相关，高于其他精神病理学。然而，SCT 仍 当前的精神病理学模型中不存在这种现象，很大程度上是因为该领域缺乏严格的纵向研究 研究检查 SCT 与其他精神病理学的关系。在横断面研究中，SCT 症状是 与内化症状持续且密切相关。初步调查结果还记录了 SCT 与自杀风险增加之间的关联。重要的是，我们的试点数据显示 SCT 预测增加 内化症状而不是相反。此外，SCT 症状可以独特地预测内化问题 而不是外化行为，这表明 SCT 可能是理解行为的独特因素 内化问题的具体发展。然而有研究将 SCT 与青少年内化症状联系起来 在几个方面受到限制，包括： (a) 使用阻碍建立 时间关联，(b) 使用方便样本（例如 ADHD）而不是针对 SCT 进行富集的样本 具体来说，(c) 未能检查将 SCT 与内化联系起来的可能机制或漏洞 症状，以及 (d) 关注学龄儿童，尽管 SCT 症状和内化问题 青春期急剧增加。本研究将通过使用前瞻性纵向研究来解决这些局限性， 跨青春期早期发育敏感期的多信息、多方法设计 检查 SCT 症状作为不同内化结果的预测因子并测试机制和 将 SCT 与丰富的 SCT 社区样本中的内化症状联系起来的漏洞 症状学。具体来说，基于社区的 330 名青少年（10-12 岁）样本 将在一年内的三个时间点招募和评估丰富的 SCT 症状。 符合 NIMH 研究领域标准 (RDoC) 倡议和发展精神病理学 框架，一个多信息、多方法的组合，涵盖生理、行为和自我报告 将使用分析单位。我们将检查维度 SCT 症状作为内化的预测因子 精神病理学随时间变化，测试SCT与内化之间纵向关系的机制 精神病理学，并探索加剧的脆弱性（生理反应性、惩罚敏感性） 这些纵向关系。建立纵向效应并确定机制的调查结果 跨分析单元的漏洞将推动 SCT 理论模型的发展。 这项研究的结果还将为有针对性的临床评估和治疗提供途径。