LSU Superfund Research Center - Environmentally Persistent Free Radicals

项目概要/摘要：总体 近5300万人（占美国人口的17%; 18%的儿童<5岁）生活在超级基金的3英里范围内 修复现场。超级基金所在地含有各种各样的污染物，包括有机化学品、金属、碳水化合物、 naceous材料and silica硅.虽然这些成分中的每一种都能对生物体造成损害，但它们的潜力- 联合收割机变成独特的危险物质的可能性还没有得到充分的研究。有趣的是，当这些代理人被预先- 特别是在热修复过程中，它们联合收割机结合形成颗粒物质（PM）， 在环境中持续存在但仍具有生物活性的吸附自由基。我们称之为污染颗粒 环境持久性自由基（EPFRs）。EPFR在HAZ的热处理过程中产生， 优选的废物和近30%的超级基金场地（不包括地下水）通过热处理进行补救- 我是说。超级基金场址附近的EPFR浓度范围为1x 1018 - 4x 1019 EPFR/g（spins/g）PM。这个糖- 大量美国居民暴露于含有EPFR的PM。路易斯安那州立大学超级基金研究中心 研究人员已经表明，这些EPFR 1）在暴露的宿主中诱导心脏和肺功能障碍，2） 如果存在于家庭灰尘中，则与儿童当前的喘鸣有关，3）是森林中的中间体- 新的污染物，如二恶英。我们的中心现在试图了解EPFR如何诱导肺- nary/cardiovascular dysfunction and how attenuated EPFR formation，facilitate EPFR decay，and limit exposure 到EPFR，最终目标是改善人类健康和环境。我们将确定EPFR如何 形成、稳定和衰变，以及它们如何催化循环产生羟基自由基。为此将 使用一套先进的表面和化学分析。由于气道是环境污染的主要入口， 精神PM，我们将证明EPFR暴露与儿童呼吸系统健康状况差之间的联系， 建立以社区为基础的生育队列。我们将探讨EPFR诱导的哮喘和心血管的机制， 使用通过吸入暴露的小鼠模型的cular疾病。支持核心（管理、数据管理和 分析，社区参与，研究经验和培训协调，材料和吸入 毒理学）将提供必要的集中试剂/服务和技术资源， 数据的精确性和努力的经济性，并促进跨学科的活动。为了确保成功，这些专家 各个领域的专家组成了一个外部咨询委员会，为该中心提供咨询。化学 和物理学的EPFR，更不用说他们的健康影响，是知之甚少， 需要解决关键的研究领域。

Project Summary/Abstract: Overall Nearly 53 million people (17% of the US population; 18% of children <5 yrs) live within 3 miles of a Superfund remediation site. Superfund sites contain a wide variety of pollutants, including organic chemicals, metals, carbo- naceous material and silica. Although each of these components is capable of damage to organisms, their poten- tial to combine into unique hazardous agents has been understudied. Interestingly, when these agents are pre- sent together, particularly during thermal remediation, they combine to form particulate matter (PM) with chemi- sorbed free radicals that persist in the environment and yet are biologically active. We call these pollutant-particle systems environmentally persistent free radicals (EPFRs). EPFRs are produced during thermal treatment of haz- ardous wastes and nearly 30% of all Superfund sites (excluding groundwater) are remediated by thermal treat- ment. EPFR concentrations near Superfund sites range from 1x1018-4x1019 EPFRs/g (spins/g) of PM. This sug- gests a vast number of US residents are exposed to PM containing EPFRs. LSU Superfund Research Center researchers have shown that these EPFRs 1) induce cardiac and pulmonary dysfunction in the exposed host, 2) are associated with current wheeze in children if present in household dust, and 3) are intermediates in the for- mation of new pollutants such as dioxins. Our Center now seeks to understand how EPFRs induce pulmo- nary/cardiovascular dysfunction and how to attenuate EPFR formation, facilitate EPFR decay, and limit exposure to EPFRs, with the ultimate goal of improving human health and the environment. We will determine how EPFRs are formed, stabilized, and decay and how they catalytically cycle to produce hydroxyl radicals. This will be done using a suite of advanced surface and chemical analyses. Since the airway is a major site of entry of environ- mental PM, we will demonstrate a link between EPFR exposure and poor respiratory health in children using es- tablished community-based birth cohorts. We will explore mechanisms of EPFR-induced asthma and cardiovas- cular disease using mouse models exposed by inhalation. Support cores (Administration, Data Management & Analysis, Community Engagement, Research Experience and Training Coordination, Materials, and Inhalation Toxicology) will provide essential, centralized reagents/services and technological resources allowing for precision of data and economy of effort, and foster interdisciplinary activities. To ensure success, experts in these respective fields were brought together as an External Advisory Committee to advise this Center. The chemistry and physics of EPFRs, let alone their health impacts, are poorly understood, and an interdisciplinary approach is required to address the critical research areas.