Measurement and estimation of lucidity prevalence in persons with dementia and neurological disorders
痴呆和神经系统疾病患者清醒率的测量和估计
基本信息
- 批准号:10091724
- 负责人:
- 金额:$ 39.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:Activities of Daily LivingAddressAgingAlzheimer&aposs DiseaseAreaAssessment toolAssisted Living FacilitiesBasic ScienceBedsCare given by nursesCaregiversCase StudyCategoriesCessation of lifeCharacteristicsClinical TrialsCollaborationsComaCommunicationComplexConsensusDataDementiaDevelopmentDiagnosisDiagnosticDiseaseDoctor of PhilosophyEducational workshopEpidemiologyEventFamilyFrequenciesFutureGeriatric PsychiatryGeriatricsGerontologyGoalsHealth care facilityHusbandIndividualInstitutesIntervention StudiesInterviewKnowledgeLinkLiteratureLong-Term CareMeasurementMeasuresMedicalMethodologyMethodsModificationNatureNeurologicNeurologyNeuronsNeurosciencesNursing HomesParticipantPatientsPersonsPhasePilot ProjectsPopulation StudyPositioning AttributePrevalenceProceduresPropertyPsychologyPsychometricsQualitative MethodsRainRecoveryReportingResearchRetrospective StudiesSamplingSignal TransductionSynapsesadjudicationcase findingend of lifeepidemiology studyinterestmultidisciplinarynervous system disorderremediationresponsestatisticssymposiumtool
项目摘要
The proposed project, “Measurement and estimation of lucidity prevalence in persons with dementia and
neurological disorders” is in response to RFA-AG-20-017 “Lucidity in Dementia (R21/R33)”. Our goals are to
develop further a measure of paradoxical lucidity and to use this measure to estimate the frequency and
correlates of occurrences by interviewing nursing home staff with respect to incidents observed in residents
during the past one-month and six-month periods. In addition, we will refine the definition of lucidity and
develop further a case-adjudication method for lucidity “diagnosis”. We propose to study staff reports related
to 300 residents of one long-term care facility during the R21 phase and 1500 residents from 12 facilities
during the R33 phase. Front line nursing home staff is ideally suited to inform research in paradoxical lucidity,
an understudied phenomenon; likely due to the transience of the incidents and the lack of scientific reporting
channels. The literature extant focuses on anecdotal evidence and case reports. The proposed study
addresses four objectives: 1) develop a measure to assess the occurrence of lucidity, 2) analyze the
psychometric properties of the measure, 3) develop a consensus conference methodology to determine
possible, probable and definite cases, and 4) conduct a local, population-based study of lucidity using direct
interviews with nursing home staff. This study will contribute to remediation of the lack of measurement tools in
the field and provide robust basic knowledge about the phenomenon of lucidity. The proposed study refines
our case finding methodology used in prior epidemiological research in nursing homes to study underlying
latent constructs that are the subject of early-stage research and require definitional clarity. The proposed team
has expertise in measurement and statistics, gerontology, neuroscience, epidemiology, geriatric medicine and
psychiatry (Alzheimer’s disease), psychology, qualitative methods, and congregate care nursing. The aims are:
Aim 1-R21: Develop a measure to describe episodes of lucidity among individuals with dementia,
neurological and other illnesses and identify individual and episodic characteristics associated with events;
Aim 2-R21: Develop further a procedure for case conferencing of reported events, using data from a
pilot sample of 300 staff reports linked to 300 unique residents with and without lucidity events residing in a
large 750-bed long term care facility;
Aim 3-R33: Conduct a retrospective study of lucidity events in 12 long-term care facilities to describe
their characteristics in comparison to residents without an event;
Aim 4-R33: Determine the prevalence and frequency of events by diagnostic categories;
Aim 5-R33: Examine the predictors of lucidity and its subtypes.
Findings could result in the development of a case-reporting methodology for use by front-line staff to identify
episodes of lucidity and to characterize lucidity events to inform future research.
拟议的项目,“测量和估计痴呆患者的清醒患病率和
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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Jose Alejandro Luchsinger其他文献
Jose Alejandro Luchsinger的其他文献
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{{ truncateString('Jose Alejandro Luchsinger', 18)}}的其他基金
Midcareer Award for Research in Dementia Risk Factors and Prevention
痴呆症风险因素和预防研究职业中期奖
- 批准号:
10645176 - 财政年份:2022
- 资助金额:
$ 39.72万 - 项目类别:
DPPOS AD/ADRD Health Economics Evaluation
DPPOS AD/ADRD 健康经济学评估
- 批准号:
10702144 - 财政年份:2022
- 资助金额:
$ 39.72万 - 项目类别:
Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project
糖尿病前期和 2 型糖尿病中的阿尔茨海默病和阿尔茨海默病相关痴呆:糖尿病预防计划成果研究 AD/ADRD 项目
- 批准号:
10901549 - 财政年份:2022
- 资助金额:
$ 39.72万 - 项目类别:
Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project
糖尿病前期和 2 型糖尿病中的阿尔茨海默病和阿尔茨海默病相关痴呆:糖尿病预防计划成果研究 AD/ADRD 项目
- 批准号:
10507628 - 财政年份:2022
- 资助金额:
$ 39.72万 - 项目类别:
Association of cumulative exposure to metformin and other T2D medications with cognitive impairment and AD/ADRD biomarkers
二甲双胍和其他 T2D 药物累积暴露与认知障碍和 AD/ADRD 生物标志物的关联
- 批准号:
10507636 - 财政年份:2022
- 资助金额:
$ 39.72万 - 项目类别:
Midcareer Award for Research in Dementia Risk Factors and Prevention
痴呆症风险因素和预防研究职业中期奖
- 批准号:
10457636 - 财政年份:2022
- 资助金额:
$ 39.72万 - 项目类别:
Measurement and estimation of lucidity prevalence in persons with dementia and neurological disorders
痴呆和神经系统疾病患者清醒率的测量和估计
- 批准号:
10688736 - 财政年份:2020
- 资助金额:
$ 39.72万 - 项目类别:
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