Administrative Core

行政核心

• 批准号: 10507629
• 负责人: Jose Alejandro Luchsinger
• 金额: $ 200.29万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10507629
• 关键词: Adherence; Adopted; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Ancillary Study; Budgets; Cognitive; Collaborations; Development; Diabetes Mellitus; Education; Ensure; Funding; Goals; Institutional Review Boards; Journals; Leadership; Ligands; Logistics; Manuscripts; Measurable; Mentorship; Minority; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; Non-Insulin-Dependent Diabetes Mellitus; Observational Study; Outcome; Outcome Study; Participant; Peer Review; Prediabetes syndrome; Preparation; Prevention Guidelines; Prevention program; Principal Investigator; Procedures; Progress Reports; Protocols documentation; Publications; Reading; Reporting; Research; Research Personnel; Resources; Scientist; Site; Structure; Travel; United States; United States Centers for Medicare and Medicaid Services; Universities; Update; Washington; base; career development; clinical center; clinical research site; data sharing; diabetes prevention program; education research; experience; meetings; programs; success; web site; working group

The goal of the Administrative Core is to provide budgetary and administrative support to the other 4 cores and 4 projects in the Diabetes Prevention Program Outcomes Study (DPPOS) Alzheimer’s Disease (AD)/AD related dementias (ADRD) Project. The Administrative Core will support the governance structure of the DPPOS AD/ADRD Project, and will interact with leadership at the National Institute on Aging (NIA) and other national AD and ADRD research and research education programs. The DPPOS has a well-developed organization that has conducted ground-breaking research in pre-diabetes (preD) and type 2 diabetes (T2D) over more than 25 years, supporting 25 clinical sites and multiple reading centers across the United States. The success of this organization is best reflected by the high level of retention of clinical centers and participants; assiduous adherence to the study protocol; hundreds of publications in high impact journals; and the development of T2D prevention guidelines and programs based on DPPOS findings that have been adopted widely, including by the Center for Medicaid and Medicare Services. The DPPOS working committees and subcommittees will remain largely intact, with the AD/ADRD Project’s Executive Committee, Steering committee, Publications and Presentations Committee, and Ancillary Studies Committee continuing into the proposed funding period under the Administrative Core. The leadership of the Administrative Core will be the same as for the overall project using a multiple principal investigator (PI) arrangement, shared by PIs Luchsinger, Nathan, and Temprosa. PI Nathan has been the chair of the DPPOS since its inception. PI Temprosa has been the leader of the DPPOS coordinating center based at George Washington University. Contact PI Luchsinger has led the Cognitive Coordinating Center of DPPOS since 2009, has co-led its Working Group on Aging, and has led NIA funded AD/ADRD research and education programs for 20 years. The Administrative Core (AC) will achieve its goals through the following specific aims: (1). Support the governance structure of the proposed U19; (2) Support all cores and projects logistically and financially; (3) Ensure administrative and regulatory compliance; (4) Support dissemination and collaboration; (5) Support mentorship and career development in T2D and AD/ADRD research; (6) To evaluate the success of the proposed research program through measurable goals and outcomes.

行政核心的目标是为其他4个核心提供预算和行政支持， 糖尿病预防计划结果研究（DPPOS）中的4个项目阿尔茨海默病（AD）/AD相关 痴呆症项目。行政核心将支持政治事务司的治理结构 AD/ADRD项目，并将与国家老龄问题研究所（NIA）和其他国家AD 和ADRD研究和研究教育计划。DPPOS有一个完善的组织， 在糖尿病前期（preD）和2型糖尿病（T2 D）方面进行了超过25年的突破性研究， 支持全美25个临床站点和多个阅读中心。的成功 组织是最好的反映了高水平的保留临床中心和参与者;勤奋 遵守研究方案;在高影响力期刊上发表数百篇论文;以及T2 D的发展 基于DPPOS调查结果的预防指南和方案已被广泛采用，包括 医疗补助和医疗保险服务中心。政治事务部各工作委员会和小组委员会将继续保留 AD/ADRD项目的执行委员会、指导委员会、出版物和 演讲委员会和辅助研究委员会继续进入拟议的资助期， 行政核心。行政核心的领导将与整个项目的领导相同 使用多个主要研究者（PI）安排，由PI Luchsinger，Nathan和Temprosa共享。Pi Nathan自成立以来一直担任DPPOS的主席。PI Temprosa一直是DPPOS的领导者 协调中心设在乔治华盛顿大学。联系PI Luchsinger领导了认知 自2009年以来，担任人口和计划生育司协调中心，共同领导其老龄问题工作组， AD/ADRD研究和教育计划20年。行政核心将实现其目标 通过以下具体目标：（1）。支持拟议的U19的治理结构;（2）支持所有 （3）确保行政和监管合规;（4）支持 （5）支持T2 D和AD/ADRD的导师制和职业发展 研究;（6）通过可衡量的目标来评估拟议研究计划的成功， 结果。