Administrative Core

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The goal of the Administrative Core is to provide budgetary and administrative support to the other 4 cores and 4 projects in the Diabetes Prevention Program Outcomes Study (DPPOS) Alzheimer’s Disease (AD)/AD related dementias (ADRD) Project. The Administrative Core will support the governance structure of the DPPOS AD/ADRD Project, and will interact with leadership at the National Institute on Aging (NIA) and other national AD and ADRD research and research education programs. The DPPOS has a well-developed organization that has conducted ground-breaking research in pre-diabetes (preD) and type 2 diabetes (T2D) over more than 25 years, supporting 25 clinical sites and multiple reading centers across the United States. The success of this organization is best reflected by the high level of retention of clinical centers and participants; assiduous adherence to the study protocol; hundreds of publications in high impact journals; and the development of T2D prevention guidelines and programs based on DPPOS findings that have been adopted widely, including by the Center for Medicaid and Medicare Services. The DPPOS working committees and subcommittees will remain largely intact, with the AD/ADRD Project’s Executive Committee, Steering committee, Publications and Presentations Committee, and Ancillary Studies Committee continuing into the proposed funding period under the Administrative Core. The leadership of the Administrative Core will be the same as for the overall project using a multiple principal investigator (PI) arrangement, shared by PIs Luchsinger, Nathan, and Temprosa. PI Nathan has been the chair of the DPPOS since its inception. PI Temprosa has been the leader of the DPPOS coordinating center based at George Washington University. Contact PI Luchsinger has led the Cognitive Coordinating Center of DPPOS since 2009, has co-led its Working Group on Aging, and has led NIA funded AD/ADRD research and education programs for 20 years. The Administrative Core (AC) will achieve its goals through the following specific aims: (1). Support the governance structure of the proposed U19; (2) Support all cores and projects logistically and financially; (3) Ensure administrative and regulatory compliance; (4) Support dissemination and collaboration; (5) Support mentorship and career development in T2D and AD/ADRD research; (6) To evaluate the success of the proposed research program through measurable goals and outcomes.