A Comprehensive Functional Map of Human Protein-RNA Interactions

人类蛋白质-RNA 相互作用的综合功能图谱

• 批准号: 10087950
• 负责人: Brenton R. Graveley
• 金额: $ 75.66万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-05 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10087950
• 关键词: Address; Binding; Cell Line; Communication; Communities; Computer software; Conflict (Psychology); DNA; Data; Data Set; Databases; Deposition; Education and Outreach; Elements; Encyclopedias; Engineering; Ensure; Environment; Fostering; Foundations; Generations; Goals; Grant; Group Meetings; Human; Human Genome; Laboratories; Leadership; Logistics; Maps; Measures; Minor; Mission; Monitor; Procedures; Production; Progress Reports; Protocols documentation; Publications; Publishing; RNA; RNA-Binding Proteins; RNA-Protein Interaction; Reagent; Research; Research Personnel; Resources; Statistical Methods; Supervision; Time; TimeLine; Training; Travel; Vision; central database; cohesion; cost; data dissemination; data quality; data repository; editorial; experience; innovation; meetings; member; operation; outreach; program dissemination; shared database; training project; transcriptome

MANAGEMENT, DISSEMINATION AND TRAINING – PROJECT SUMMARY The objective of the ENCORE (Encyclopedia of RNA Elements) project is to develop a foundational, functional map of protein-RNA interactions of RNA binding proteins (RBPs) encoded in the human genome, and the RNA elements they bind to across the transcriptome. The Management, Dissemination and Training Core is tasked with the overall management of the project, dissemination of the data to the public, and outreach and training to the community to maximize the utility and impact of this resource. Specifically, this core will provide guidance and promote productive interactions among all members of this project by developing a collaborative team environment. In addition, the core will ensure scientific rigor and transparency and oversee outreach and sharing. The core will also provide general administrative support and fiscal oversight for the project. Much of this will be facilitated by the use of innovative communication and data tracking software. The core is also responsible for coordinating regular meetings between group meetings as well as an annual meeting between group members and a to-be-appointed Scientific Advisory Board to frankly assess strengths and weaknesses of the project.

管理、传播和培训——项目摘要 ENCORE（RNA 元素百科全书）项目的目标是开发一种 RNA 结合蛋白的蛋白质-RNA 相互作用的基础功能图 (RBP) 编码在人类基因组中，以及它们与整个基因组结合的 RNA 元件 转录组。管理、传播和培训核心的任务是 项目的总体管理、向公众传播数据和推广 并对社区进行培训，以最大限度地发挥这一资源的效用和影响。 具体而言，该核心将为各方提供指导并促进富有成效的互动。 通过开发一个协作团队环境，该项目的所有成员。此外， 核心人员将确保科学严谨性和透明度，并监督外展和共享。 该核心还将提供一般行政支持和财政监督 项目。其中大部分将通过创新通信和数据的使用来促进 跟踪软件。核心还负责协调定期会议 小组会议之间以及小组成员和成员之间的年度会议 即将任命的科学顾问委员会将坦诚评估优势和劣势 项目的。