Inflammation and alcohol-related racial/ethnic health disparities

炎症和酒精相关的种族/民族健康差异

• 批准号: 10092048
• 负责人: Priscilla Martinez
• 金额: $ 14.41万
• 依托单位: PUBLIC HEALTH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10092048
• 关键词: Address; Adolescent; Adult; Alcohol consumption; Alcohols; Anti-Inflammatory Agents; Applied Research; Award; Behavior; Behavioral; Biological; Biological Markers; Biological Sciences; Blood; Blood specimen; Chronic; Collection; Data; Data Analyses; Data Collection; Development; Diabetes Mellitus; Diet; Disease; Ensure; Environmental Health; Environmental Risk Factor; Epidemiology; Ethnic Origin; Ethnic group; Exercise; Exposure to; Foundations; Funding; General Population; Goals; Health; Health behavior; Human Resources; Hypertension; Immune Targeting; Immune response; Immune system; Immunologic Markers; Immunologics; Individual; Inflammation; Inflammatory Response; Injury; Intervention; Investigation; Irritants; K-Series Research Career Programs; Knowledge; Latino; Longitudinal Studies; Measures; Mediating; Mediator of activation protein; Mental Depression; Mental Health; Mentors; Mentorship; Methodology; Methods; National Institute on Alcohol Abuse and Alcoholism; Outcome; Participant; Pathway interactions; Pattern; Physiological; Population Study; Prevention; Principal Investigator; Prospective Studies; Race; Research; Research Activity; Research Personnel; Resources; Risk; Role; Sample Size; Sampling; Scientist; Self Administration; Severities; Shapes; Sleep; Spottings; Statistical Models; Sum; Surveys; Techniques; Technology; Testing; Training; United States National Institutes of Health; Ursidae Family; Venipunctures; acceptability and feasibility; alcohol effect; alcohol epidemiology; alcohol research; career; career development; comorbidity; cost; cost effective; drinking; environmental stressor; ethnic health disparity; ethnic minority population; experience; health disparity; hypertension treatment; novel; physical conditioning; population based; population survey; prospective; racial and ethnic; racial and ethnic disparities; secondary analysis; skills; social

ABSTRACT Alcohol-related health problems include highly prevalent and serious disorders such as hypertension, diabetes, and depression. Substantial evidence supports a J-shaped relationship between alcohol use and diabetes1, whereas a linear relationship is well-documented between alcohol use and hypertension2, and there is mixed evidence regarding the shape of the relationship between alcohol use and depression3,4. A common biologic mechanism for alcohol's effects on these disorders may be inflammation. Inflammation is a general response by the immune system to harm, such as bodily injury or exposure to irritants (e.g. alcohol)5. Inflammation that becomes chronic, potentially lasting for years, is associated with an increased risk of health problems6, including hypertension, diabetes, and depression7. Thus, intervening on inflammation offers new opportunities for prevention and treatment. However, the mechanisms of inflammation in the context of alcohol use and health require further study. Racial/ethnic health disparities are especially relevant in this context because racial/ethnic minorities share a disproportionately large portion of the burden caused by these disorders8. Moreover, recent studies show racial/ethnic minorities have consistently higher levels of inflammation9, and these differences have been observed across the lifespan10,11. The overall objective of this K01 Career Development Award is to provide the principal investigator, Dr. Martinez, with the skills necessary to conduct alcohol research that bridges social, behavioral, and physiological domains. The research activities proposed under this award will lead to a better understanding of alcohol use and inflammation as mechanisms contributing to alcohol-related racial/ethnic health disparities. In turn, findings will inform the development and implementation of a subsequent R01-funded longitudinal investigation of immunologic mechanisms and associated factors that may explain differential drinking patterns and related physical and mental health outcomes among racial/ethnic minorities. Upon completion of study activities, Dr. Martinez will be poised for a productive career as an independent, NIH-funded scientist. Dr. Martinez is trained as an alcohol researcher with a strong background in the biological sciences and expertise in alcohol epidemiology, particularly the comorbidity between alcohol use and depression. Dr. Martinez's long-term goal is to become a successful NIH-funded scientist with expertise in the relationships between biologic mechanisms and alcohol-related racial/ethnic health disparities. She is proposing a combination of didactic and applied research activities, under the mentorship of experts in the field led by her primary mentor Dr. Sarah Zemore, to provide her with the following skills necessary to accomplish this goal: (1) expertise in the role of inflammation in mental and physical health, (2) expertise in racial/ethnic disparities in the effects of alcohol on mental and physical health, (3) longitudinal statistical modeling techniques, and (4) field methods in epidemiologic and biomarker data collection. The proposed research activities consist of two studies (A & B) with two aims each. Study A is a secondary analysis of data from Waves I-V of the National Longitudinal Study of Adolescent to Adult Health (AddHealth). Study B entails primary pilot data collection via self-administered dried blood spots (saDBS) from a subsample of the 2020 National Alcohol Survey (NAS). Study A, Aim I: To describe the longitudinal relationships between alcohol use, inflammation, and health outcomes (hypertension, diabetes, and depression). Dr. Martinez will accomplish this aim by: (a) examining the individual associations between alcohol use and inflammation and health with prospective data from AddHealth, and (b) testing inflammation as a mediator of the relationships between alcohol use and each health outcome. Study A, Aim II: To describe how race/ethnicity impacts alcohol's effects on health via inflammation and the roles of environmental stressors and unhealthy behaviors. Dr. Martinez will accomplish this aim by: (a) testing whether the effects of alcohol use on inflammation and health are stronger among racial/ethnic minorities compared to Whites, and (b) testing whether environmental factors and health behaviors mediate the effect of race/ethnicity on the relationships between alcohol use and inflammation and health. Study B, Aim I: To pilot test the use of a novel biosample collection method (self-administered dried blood spots (saDBS)). Dr. Martinez will accomplish this aim by: (a) assessing the acceptability and feasibility of saDBS among a sample of NAS participants, and (b) assessing the participant's experience of completing a saDBS sample. Study B, Aim II: To explore additional immune markers relevant to the relationships between alcohol use, inflammation and health across racial/ethnic groups in a nationally representative adult sample. Dr. Martinez will accomplish this aim by: (a) exploring immune markers beyond those included in Study A using the NAS, and (b) exploring associations between these immune markers and alcohol use and health across racial/ethnic groups. These research activities will culminate in the submission of an R01 as part of NIAAA's Health Disparities Initiative to study prospectively the effect of immunological mechanisms on alcohol-related health outcomes across racial/ethnic groups. The career development and research activities proposed in this K01 application will lay the foundation for Dr. Martinez's career as a successful, independent, NIH-funded scientist.

摘要 与酒精有关的健康问题包括高度流行和严重的疾病，如高血压， 糖尿病和抑郁症大量证据支持酒精使用和饮酒之间的J形关系。 糖尿病1，而酒精使用和高血压2之间的线性关系是有据可查的， 关于酒精使用和抑郁症之间关系的形状的证据是混合的3，4。一个共同 酒精对这些疾病影响的生物学机制可能是炎症。炎症是一种 免疫系统对伤害的反应，如身体受伤或暴露于刺激物（如酒精）5。 炎症变成慢性，可能持续多年，与健康风险增加有关 问题6，包括高血压、糖尿病和抑郁症7。因此，干预炎症提供了新的 预防和治疗的机会。然而，酒精环境下的炎症机制 使用和健康需要进一步研究。在这方面，种族/族裔的健康差距尤其重要 因为种族/族裔少数群体分担了不成比例的大部分负担， 紊乱8.此外，最近的研究表明，少数种族/族裔的 炎症9，这些差异已在整个生命周期中观察到10，11。 这个K 01职业发展奖的总体目标是提供主要研究者，博士。 马丁内斯，与必要的技能进行酒精研究，桥梁的社会，行为， 生理领域。根据该奖项提出的研究活动将导致更好地了解 酒精使用和炎症是导致酒精相关种族/民族健康差异的机制。在 反过来，调查结果将为后续R 01资助的纵向 免疫机制和相关因素的调查，可以解释不同的饮酒模式 以及少数种族/族裔的相关身心健康结果。完成研究后 活动，马丁内斯博士将准备作为一个独立的，NIH资助的科学家富有成效的职业生涯。 马丁内斯博士是一名训练有素的酒精研究员，具有强大的生物科学背景， 酒精流行病学的专业知识，特别是酒精使用和抑郁症之间的共病。博士 马丁内斯的长期目标是成为一名成功的NIH资助的科学家，拥有人际关系方面的专业知识 生物机制和酒精相关的种族/民族健康差异之间的关系。她提出了一个 教学和应用研究活动相结合，在她领导的领域专家的指导下， 主要导师Sarah Zemore博士，为她提供实现这一目标所需的以下技能：（1） 炎症在精神和身体健康中的作用的专业知识，（2）种族/民族差异的专业知识， 酒精对身心健康的影响，（3）纵向统计建模技术，（4） 流行病学和生物标志物数据收集的现场方法。 拟议的研究活动包括两项研究（A和B），每项研究有两个目标。研究A是一个 青少年到成人健康国家纵向研究第一至第五波数据的二次分析 （AddHealth）.研究B需要通过自给干血斑（saDBS）收集初步试验数据， 2020年全国酒精调查（NAS）的子样本。研究A，目的I：描述纵向 饮酒、炎症和健康结果（高血压、糖尿病和 抑郁症）。马丁内斯博士将通过以下方式实现这一目标：（a）检查 使用AddHealth的前瞻性数据，研究酒精使用、炎症和健康，以及（B）测试炎症， 酒精使用和每个健康结果之间的关系的调解人。研究A，目标II：描述 种族/民族如何通过炎症和环境压力因素的作用影响酒精对健康的影响 和不健康的行为。马丁内斯博士将通过以下方式实现这一目标：（a）测试酒精使用的影响是否 与白人相比，少数种族/民族对炎症和健康的影响更大，（B）测试 环境因素和健康行为是否介导种族/民族对关系的影响 饮酒、炎症和健康之间的联系研究B，目的I：对新型生物样本的使用进行初步测试 采集方法（自给干血斑（saDBS））。马丁内斯博士将通过以下方式实现这一目标：（a） 在NAS参与者样本中评估saDBS的可接受性和可行性，以及（B）评估 参与者完成saDBS样本的经历。研究B，目的II：探索额外的免疫 与不同种族/民族的酒精使用、炎症和健康之间关系相关的标志物 在一个全国代表性的成人样本中。马丁内斯博士将通过以下方式实现这一目标：（a）探索免疫 使用NAS研究A中包括的标记物之外的标记物，以及（B）探索这些标记物之间的关联 免疫标记物和酒精使用以及种族/民族群体的健康状况。 这些研究活动将最终提交R 01，作为NIAAA健康 前瞻性研究免疫机制对酒精相关健康的影响 跨种族/族裔群体的结果。本K 01中提出的职业发展和研究活动 申请将为Martinez博士作为一名成功的、独立的、NIH资助的科学家的职业生涯奠定基础。

项目成果

Mental health and drinking to cope in the early COVID period: Data from the 2019-2020 US National Alcohol Survey.

• DOI: 10.1016/j.addbeh.2022.107247
• 发表时间: 2022-05
• 期刊: Addictive behaviors
• 影响因子: 4.4
• 作者: Martinez P;Karriker-Jaffe KJ;Ye Y;Patterson D;Greenfield TK;Mulia N;Kerr WC
• 通讯作者: Kerr WC

Hazardous Drinking Prevalence and Correlates in Older New Zealanders: A Comparison of the AUDIT-C and the CARET.

新西兰人的危险饮酒患病率和相关性：审计-C和室的比较。

• DOI: 10.1177/0898264318794108
• 发表时间: 2019-12
• 期刊: Journal of aging and health
• 影响因子: 2.8
• 作者: Towers A;Szabó Á;Newcombe DAL;Sheridan J;Moore AA;Hyde M;Britton A;Martinez P;Minicuci N;Kowal P;Clausen T;Savage CL
• 通讯作者: Savage CL

Parental risk constellations and future alcohol use disorder (AUD) in offspring: A combined HUNT survey and health registries study.

• DOI: 10.1037/adb0000681
• 发表时间: 2022-06
• 期刊: Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
• 作者: Burdzovic Andreas J;Ask Torvik F;Ystrom E;Skurtveit S;Handal M;Martinez P;Laslett AM;Lund IO
• 通讯作者: Lund IO