Inflammation and alcohol-related racial/ethnic health disparities

炎症和酒精相关的种族/民族健康差异

• 批准号: 10092048
• 负责人: Priscilla Martinez
• 金额: $ 14.41万
• 依托单位: PUBLIC HEALTH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10092048
• 关键词: Address; Adolescent; Adult; Alcohol consumption; Alcohols; Anti-Inflammatory Agents; Applied Research; Award; Behavior; Behavioral; Biological; Biological Markers; Biological Sciences; Blood; Blood specimen; Chronic; Collection; Data; Data Analyses; Data Collection; Development; Diabetes Mellitus; Diet; Disease; Ensure; Environmental Health; Environmental Risk Factor; Epidemiology; Ethnic Origin; Ethnic group; Exercise; Exposure to; Foundations; Funding; General Population; Goals; Health; Health behavior; Human Resources; Hypertension; Immune Targeting; Immune response; Immune system; Immunologic Markers; Immunologics; Individual; Inflammation; Inflammatory Response; Injury; Intervention; Investigation; Irritants; K-Series Research Career Programs; Knowledge; Latino; Longitudinal Studies; Measures; Mediating; Mediator of activation protein; Mental Depression; Mental Health; Mentors; Mentorship; Methodology; Methods; National Institute on Alcohol Abuse and Alcoholism; Outcome; Participant; Pathway interactions; Pattern; Physiological; Population Study; Prevention; Principal Investigator; Prospective Studies; Race; Research; Research Activity; Research Personnel; Resources; Risk; Role; Sample Size; Sampling; Scientist; Self Administration; Severities; Shapes; Sleep; Spottings; Statistical Models; Sum; Surveys; Techniques; Technology; Testing; Training; United States National Institutes of Health; Ursidae Family; Venipunctures; acceptability and feasibility; alcohol effect; alcohol epidemiology; alcohol research; career; career development; comorbidity; cost; cost effective; drinking; environmental stressor; ethnic health disparity; ethnic minority population; experience; health disparity; hypertension treatment; novel; physical conditioning; population based; population survey; prospective; racial and ethnic; racial and ethnic disparities; secondary analysis; skills; social

ABSTRACT Alcohol-related health problems include highly prevalent and serious disorders such as hypertension, diabetes, and depression. Substantial evidence supports a J-shaped relationship between alcohol use and diabetes1, whereas a linear relationship is well-documented between alcohol use and hypertension2, and there is mixed evidence regarding the shape of the relationship between alcohol use and depression3,4. A common biologic mechanism for alcohol's effects on these disorders may be inflammation. Inflammation is a general response by the immune system to harm, such as bodily injury or exposure to irritants (e.g. alcohol)5. Inflammation that becomes chronic, potentially lasting for years, is associated with an increased risk of health problems6, including hypertension, diabetes, and depression7. Thus, intervening on inflammation offers new opportunities for prevention and treatment. However, the mechanisms of inflammation in the context of alcohol use and health require further study. Racial/ethnic health disparities are especially relevant in this context because racial/ethnic minorities share a disproportionately large portion of the burden caused by these disorders8. Moreover, recent studies show racial/ethnic minorities have consistently higher levels of inflammation9, and these differences have been observed across the lifespan10,11. The overall objective of this K01 Career Development Award is to provide the principal investigator, Dr. Martinez, with the skills necessary to conduct alcohol research that bridges social, behavioral, and physiological domains. The research activities proposed under this award will lead to a better understanding of alcohol use and inflammation as mechanisms contributing to alcohol-related racial/ethnic health disparities. In turn, findings will inform the development and implementation of a subsequent R01-funded longitudinal investigation of immunologic mechanisms and associated factors that may explain differential drinking patterns and related physical and mental health outcomes among racial/ethnic minorities. Upon completion of study activities, Dr. Martinez will be poised for a productive career as an independent, NIH-funded scientist. Dr. Martinez is trained as an alcohol researcher with a strong background in the biological sciences and expertise in alcohol epidemiology, particularly the comorbidity between alcohol use and depression. Dr. Martinez's long-term goal is to become a successful NIH-funded scientist with expertise in the relationships between biologic mechanisms and alcohol-related racial/ethnic health disparities. She is proposing a combination of didactic and applied research activities, under the mentorship of experts in the field led by her primary mentor Dr. Sarah Zemore, to provide her with the following skills necessary to accomplish this goal: (1) expertise in the role of inflammation in mental and physical health, (2) expertise in racial/ethnic disparities in the effects of alcohol on mental and physical health, (3) longitudinal statistical modeling techniques, and (4) field methods in epidemiologic and biomarker data collection. The proposed research activities consist of two studies (A & B) with two aims each. Study A is a secondary analysis of data from Waves I-V of the National Longitudinal Study of Adolescent to Adult Health (AddHealth). Study B entails primary pilot data collection via self-administered dried blood spots (saDBS) from a subsample of the 2020 National Alcohol Survey (NAS). Study A, Aim I: To describe the longitudinal relationships between alcohol use, inflammation, and health outcomes (hypertension, diabetes, and depression). Dr. Martinez will accomplish this aim by: (a) examining the individual associations between alcohol use and inflammation and health with prospective data from AddHealth, and (b) testing inflammation as a mediator of the relationships between alcohol use and each health outcome. Study A, Aim II: To describe how race/ethnicity impacts alcohol's effects on health via inflammation and the roles of environmental stressors and unhealthy behaviors. Dr. Martinez will accomplish this aim by: (a) testing whether the effects of alcohol use on inflammation and health are stronger among racial/ethnic minorities compared to Whites, and (b) testing whether environmental factors and health behaviors mediate the effect of race/ethnicity on the relationships between alcohol use and inflammation and health. Study B, Aim I: To pilot test the use of a novel biosample collection method (self-administered dried blood spots (saDBS)). Dr. Martinez will accomplish this aim by: (a) assessing the acceptability and feasibility of saDBS among a sample of NAS participants, and (b) assessing the participant's experience of completing a saDBS sample. Study B, Aim II: To explore additional immune markers relevant to the relationships between alcohol use, inflammation and health across racial/ethnic groups in a nationally representative adult sample. Dr. Martinez will accomplish this aim by: (a) exploring immune markers beyond those included in Study A using the NAS, and (b) exploring associations between these immune markers and alcohol use and health across racial/ethnic groups. These research activities will culminate in the submission of an R01 as part of NIAAA's Health Disparities Initiative to study prospectively the effect of immunological mechanisms on alcohol-related health outcomes across racial/ethnic groups. The career development and research activities proposed in this K01 application will lay the foundation for Dr. Martinez's career as a successful, independent, NIH-funded scientist.

抽象的 与酒精有关的健康问题包括高度普遍和严重的疾病，例如高血压， 糖尿病和抑郁症。大量证据支持酒精使用和 糖尿病1，而线性关系在酒精使用和高血压2之间有充分的文献记录，在那里 是关于酒精使用与抑郁症之间关系形状的不同证据。3,4。常见 酒精对这些疾病的影响的生物学机制可能是炎症。炎症是一般 免疫系统对伤害的反应，例如身体损伤或暴露于刺激物（例如酒精）5。 炎症变为长期，可能持续多年，与健康风险增加有关 问题6，包括高血压，糖尿病和抑郁症7。因此，介入炎症提供了新的 预防和治疗的机会。但是，酒精背景下的炎症机制 使用和健康需要进一步研究。在这种情况下，种族/种族健康差异尤其重要 因为种族/族裔少数群体在这些造成的负担中有很多不成比例的负担 疾病8。此外，最近的研究表明，种族/族裔少数群体始终保持更高的水平 炎症9，并且在整个生命周期中都观察到了这些差异。 该K01职业发展奖的总体目标是为主要研究者提供。 马丁内斯（Martinez 生理领域。根据该奖项提出的研究活动将使人们更好地理解 酒精使用和炎症是导致与酒精有关的种族/种族健康差异的机制。在 转弯，调查结果将为随后的R01资助的纵向发展和实施 调查免疫机制和相关因素，这些因素可能解释了差异饮酒模式 以及种族/族裔少数民族之间的相关身心健康结果。完成学习后 活动，马丁内斯博士将成为一名独立的，由NIH资助的科学家，从事富有成效的职业。 Martinez博士在生物科学和 酒精流行病学方面的专业知识，尤其是酒精使用与抑郁症之间的合并症。博士 马丁内斯（Martinez）的长期目标是成为一名成功的NIH资助科学家 生物学机制与酒精相关的种族/种族健康差异之间。她正在提议 在她领导的专家的指导下，教学活动和应用研究活动的结合 主要导师莎拉·泽莫尔（Sarah Zemore）博士为她提供以下技能来实现这一目标：（1） 炎症在心理和身体健康中的作用方面的专业知识，（2）种族/种族差异方面的专业知识 酒精对心理和身体健康的影响，（3）纵向统计建模技术，以及（4） 流行病学和生物标志物数据收集中的现场方法。 拟议的研究活动包括两项研究（A＆B），每个研究都有两个目标。研究A是 国家纵向研究对成人健康的国家纵向研究的数据二级分析 （AddHealth）。研究B需要通过自我管理的干血点（SADB）收集主要的试点数据 2020年国家酒精调查（NAS）的子样本。研究A，目的I：描述纵向 酒精使用，炎症和健康结果之间的关系（高血压，糖尿病和 沮丧）。 Martinez博士将通过：（a）检查这个目标 酒精使用，炎症和健康以及来自AddHealth的预期数据，以及（b）测试炎症为 酒精使用与每种健康结果之间关系的调解人。研究A，目标II：描述 种族/民族如何通过炎症和环境压力源的作用影响酒精对健康的影响 和不健康的行为。马丁内斯博士将通过：（a）测试酒精的影响是否是否 与白人相比 环境因素和健康行为是否介导种族/种族对关系的影响 酒精使用与炎症和健康之间。研究B，目标I：试点测试新型生物样品的使用 收集方法（自我管理的干血点（SADB））。马丁内斯博士将通过：（a）实现这一目标 评估NAS参与者样本中SADB的可接受性和可行性，以及（b）评估 参与者完成SADBS样本的经验。研究B，AIM II：探索其他免疫力 与种族/种族之间的酒精使用，炎症和健康之间的关系有关的标记 在全国代表性的成人样本中。马丁内斯博士将通过：（a）探索免疫 超出了使用NA的研究A中包含的标记，以及（b）探索它们之间的关联 跨种族/族裔群体的免疫标记和饮酒和健康。 这些研究活动将在R01的提交中达到顶峰，这是NIAAA健康的一部分 差异性倡议前瞻性研究免疫机制对酒精相关健康的影响 种族/族裔群体的成果。这本K01提出的职业发展和研究活动 应用程序将为马丁内斯博士作为一名成功，独立，NIH资助的科学家的职业奠定基础。

项目成果

Mental health and drinking to cope in the early COVID period: Data from the 2019-2020 US National Alcohol Survey.

• DOI: 10.1016/j.addbeh.2022.107247
• 发表时间: 2022-05
• 期刊: Addictive behaviors
• 影响因子: 4.4
• 作者: Martinez P;Karriker-Jaffe KJ;Ye Y;Patterson D;Greenfield TK;Mulia N;Kerr WC
• 通讯作者: Kerr WC

Hazardous Drinking Prevalence and Correlates in Older New Zealanders: A Comparison of the AUDIT-C and the CARET.

• DOI: 10.1177/0898264318794108
• 发表时间: 2019-12
• 期刊: Journal of aging and health
• 影响因子: 2.8
• 作者: Towers A;Szabó Á;Newcombe DAL;Sheridan J;Moore AA;Hyde M;Britton A;Martinez P;Minicuci N;Kowal P;Clausen T;Savage CL
• 通讯作者: Savage CL

Parental risk constellations and future alcohol use disorder (AUD) in offspring: A combined HUNT survey and health registries study.

• DOI: 10.1037/adb0000681
• 发表时间: 2022-06
• 期刊: Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
• 作者: Burdzovic Andreas J;Ask Torvik F;Ystrom E;Skurtveit S;Handal M;Martinez P;Laslett AM;Lund IO
• 通讯作者: Lund IO