High-Speed Biplane X-Ray Fluoro/CT System for Translational Cardiovascular Resear

用于转化心血管研究的高速双平面 X 射线荧光/CT 系统

• 批准号: 7840571
• 负责人: MICHAEL V MCCONNELL
• 金额: $ 219.8万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-04 至 2012-03-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7840571
• 关键词: 20 year old; Ablation; American; Anatomy; Angiography; Animal Experimentation; Animal Model; Animals; Arts; Biological; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Catheters; Cells; Complement; Coronary; Development; Disease; Equipment; Floor; Fluoroscopy; Fostering; Funding; Gene Delivery; Heart; Heart Atrium; Heart Rate; Housing; Image; Institutes; Intervention; Laboratory Animal Production and Facilities; Location; Magnetic Resonance Imaging; Maps; Mechanics; Medicine; Methods; Mission; Monitor; Myocardial; Natural regeneration; Occupations; Operating Rooms; Operative Surgical Procedures; Patient Care; Patients; Physiological; Physiology; Preparation; Pulmonary veins; Research; Research Personnel; Roentgen Rays; Speed; System; Testing; Translating; Translational Research; Ultrasonography; Universities; Ventricular; base; cardiovascular imaging; improved; instrument; novel; pressure; public health relevance; research facility; soft tissue

DESCRIPTION (provided by applicant): The Falk Cardiovascular Research Center, founded by Norman Shumway, is the core translational research facility of the Stanford Cardiovascular Institute (CVI), Department of Cardiothoracic Surgery, and Division of Cardiovascular Medicine. The requested instrument is to replace the 20-year-old x-ray fluoroscopy system in the Falk Center with a state-of-the-art system that combines 3 high-end functions necessary for advancing translational cardiovascular research - biplane imaging, high- speed frame rates, and rapid rotational imaging to provide CT-like soft-tissue imaging and 3D angiography. The Falk location is ideal as it has an entire floor dedicated to animal research, with preparation/housing facilities, operating rooms, 2D/3D echo systems, a 3T MRI system, and additional cardiovascular imaging and research equipment (physiologic/electrical monitoring, intravascular ultrasound, flow/pressure wires, etc.). A wide range of NIH-funded CVI users will benefit from this system, with projects ranging from myocardial/valvular mechanics, myocardial regeneration therapy/imaging, coronary and ventricular physiology, and image-guided cardiovascular interventions. Among the system's features, the biplane fluoroscopy (typically from two orthogonal planes) allows improved spatial guidance for advanced catheter-based interventions (e.g., myocardial delivery, electrophysiological ablation) as well as 3D localization of myocardial markers. High-speed frame rates (60fps) from both planes are critical for tracking rapidly moving myocardial and valvular markers and are advantageous at higher heart rates, allowing a broader range of animal models and physiologic conditions. Finally, rotational CT-like imaging opens a wide-range of capabilities - myocardial imaging to improve localization of cell/gene delivery or electrophysiological ablation plus 3D angiography to provide atrial/pulmonary vein mapping for ablation and provide arterial anatomic mapping for interventions - with adjacent 3T MRI/3D echo to compare and/or complement. With the ongoing challenge of supporting large-animal research facilities, this system is critical as a core research instrument in the Falk Center, the only Stanford facility capable of multi-disciplinary large-animal research. There is strong institutional commitment as it fosters to the long-term mission of the CVI - translating promising biological and technical developments from across the University through large-animal studies toward advances in patient care. PUBLIC HEALTH RELEVANCE: This proposal is to support a new, high-end x-ray imaging system to enhance research in heart and blood vessel disease. It will allow for the development and testing of novel methods to detect and treat cardiovascular disease to make sure they are safe and effective for use in patients. This funding will help support the jobs of Stanford researchers as well as the American jobs of the instrument company. It will also replace an older x-ray system with a more environmentally friendly system.

描述（申请人提供）：福尔克心血管研究中心由诺曼·沙姆威（Norman Shumway）创立，是斯坦福心血管研究所（CVI）、心胸外科和心血管医学部的核心转化研究机构。所要求的仪器旨在用最先进的系统取代福克中心已有 20 年历史的 X 射线透视系统，该系统结合了推进转化心血管研究所需的 3 种高端功能——双平面成像、高速帧速率和快速旋转成像，以提供类似 CT 的软组织成像和 3D 血管造影。福尔克的位置非常理想，因为它有一整层楼专门用于动物研究，配有准备/饲养设施、手术室、2D/3D 回波系统、3T MRI 系统以及额外的心血管成像和研究设备（生理/电监测、血管内超声、流量/压力线等）。 NIH 资助的众多 CVI 用户将受益于该系统，其项目范围包括心肌/瓣膜力学、心肌再生治疗/成像、冠状动脉和心室生理学以及图像引导心血管干预。在该系统的功能中，双平面透视（通常来自两个正交平面）可以改进基于导管的先进干预措施（例如心肌输送、电生理消融）的空间引导以及心肌标记物的 3D 定位。两个平面的高速帧速率 (60fps) 对于跟踪快速移动的心肌和瓣膜标记至关重要，并且在较高心率下具有优势，从而允许更广泛的动物模型和生理条件。最后，类似旋转 CT 的成像开启了广泛的功能 - 心肌成像可改善细胞/基因传递的定位或电生理消融加上 3D 血管造影，为消融提供心房/肺静脉标测，并为干预提供动脉解剖标测 - 与相邻的 3T MRI/3D 回波进行比较和/或补充。面对支持大型动物研究设施的持续挑战，该系统作为福克中心的核心研究仪器至关重要，福尔克中心是斯坦福大学唯一能够进行多学科大型动物研究的设施。 CVI 的长期使命是通过大型动物研究将整个大学有前景的生物和技术发展转化为患者护理方面的进步，这是强有力的机构承诺。 公共健康相关性：该提案旨在支持新型高端 X 射线成像系统，以加强对心脏和血管疾病的研究。它将允许开发和测试检测和治疗心血管疾病的新方法，以确保它们对患者使用是安全有效的。这笔资金将有助于支持斯坦福大学研究人员的工作以及仪器公司在美国的工作。它还将用更环保的系统取代旧的 X 射线系统。

项目成果

Electrophysiological mapping of the epicardium via 3D-printed flexible arrays.

• DOI: 10.1002/btm2.10575
• 发表时间: 2023-11
• 期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE
• 影响因子: 7.4
• 作者: Pong, Terrence;Cyr, Kevin J.;Carlton, Cody;Aparicio-Valenzuela, Joy;Wang, Hanjay;Babakhanian, Meghedi;Maiuolo, Alessandro;Lucian, Haley;Wang, Paul J.;Woo, Y. Joseph;Lee, Anson M.
• 通讯作者: Lee, Anson M.

High-resolution spatiotemporal changes in dominant frequency and structural organization during persistent atrial fibrillation.

• DOI: 10.1371/journal.pone.0271846
• 发表时间: 2023
• 期刊: PloS one
• 影响因子: 3.7