Fogarty International Training Program in HIV- and AIDS-Associated Malignancies

描述（由申请人提供）：本申请提议继续并扩大福格蒂艾滋病毒和艾滋病相关恶性肿瘤国际培训计划。内布拉斯加州福格蒂培训项目的总体目标是在内布拉斯加州大学及其美国合作机构为赞比亚和中国的生物医学科学家和卫生保健提供者提供培训，以提高他们在与艾滋病毒和艾滋病相关的恶性肿瘤方面进行高质量生物医学、行为和预防性研究的专业知识和能力。我们的目标是继续培训研究员应用分子技术和新的医学方法，了解艾滋病毒和其他与艾滋病有关的癌症病毒如何引起疾病，并培训研究员了解用于检测/预防疾病传播和与艾滋病有关的恶性肿瘤发展的战略。同时扩大我们目前的培训活动，以包括治疗与艾滋病毒和艾滋病有关的恶性肿瘤以及与长期监测和管理受感染和接受治疗的个人有关的问题。这些目标将通过以下具体目标来实现：1)在内布拉斯加大学提供密集的学术指导，使学生获得生物医学科学硕士、公共卫生硕士和博士学位；2)为研究员提供在内布拉斯加州大学、阿拉巴马大学伯明翰分校和迈阿密大学参加生物医学研究轮转的机会，研究艾滋病病毒、人类乳头状瘤病毒、卡波西肉瘤相关疱疹病毒和爱泼斯坦巴尔病毒在艾滋病相关恶性肿瘤发展中的作用，并培训使用先进的实验室方法检测病原体和监测艾滋病毒基因型；3)为研究员提供在迈阿密大学参加艾滋病临床管理、抗病毒治疗和艾滋病相关恶性肿瘤轮转的机会；4)在内布拉斯加大学和阿拉巴马大学伯明翰分校提供关于艾滋病毒/艾滋病和与艾滋病有关的恶性肿瘤的流行病学和社会行为方面的培训，以改进国内数据分析并促进公共卫生干预战略的制定和评价；5)提供由回国研究员组织的流行病学、行为干预和实验室技术方面的国内课程和讲习班，对象是国内临床医生和公共卫生人员。内布拉斯加州病毒学中心，全国最重要的病毒学研究和培训中心之一，将继续管理这个项目。该项目势头强劲，成功地解决了艾滋病教育和预防方面的迫切需求。在今后五年中，该方案将继续保持这一势头，并解决一项新的需求，即迫切需要基础设施和专业知识，以应对扩大抗逆转录病毒治疗方案。

DESCRIPTION (provided by applicant): This application proposes to continue and to expand the Fogarty International Training Program in HIV- and AIDS-Associated Malignancies. The overall goal of the Nebraska Fogarty Training Program is to provide training at the University of Nebraska and its collaborating U.S. institutions for Zambian and Chinese biomedical scientists and health care providers to increase their expertise and capability to perform high quality biomedical, behavioral, and preventative research in HIV- and AIDS-associated malignancies. Our objective is to continue to train fellows to apply molecular techniques and new medical approaches to understand how HIV and other AIDS-associated cancer viruses cause diseases and train fellows in strategies used to detect/prevent disease transmission and the development of AIDS-related malignancies, while expanding our current training activities to include treatment of HIV- and AIDS-associated malignancies and issues related to the long-term monitoring and management of infected and treated individuals. These objectives will be achieved through the following specific aims: 1) Provide intensive academic instruction at the University of Nebraska leading to M.S., M.P.H., and Ph.D. degrees in biomedical science; 2) Provide opportunities for fellows to participate in biomedical research rotations at the University of Nebraska, the University of Alabama at Birmingham, and the University of Miami to investigate the role of HIV, Human Papilloma Virus, Kaposi's sarcoma-associated Herpes virus, and Epstein Barr virus in the development of AIDS-associated malignancies, and train in advanced laboratory methods to detect pathogens and monitor HIV genotypes; 3) Provide opportunities for fellows to participate in rotations in the clinical management of AIDS, anti-viral treatments, and AIDS-associated malignancies at the University of Miami; 4) Provide training in epidemiology and socio-behavioral aspects of HIV-AIDS and AIDS-associated malignancies at the University of Nebraska and the University of Alabama at Birmingham to improve in-country data analysis and facilitate the development and evaluation of public health intervention strategies; 5) Provide in-country courses and workshops in epidemiology, behavioral interventions, and laboratory techniques that will be organized by returning fellows for a target audience of in-country clinicians and public health personnel. The Nebraska Center for Virology, one of the nation's premier virology research and training centers, will continue to administer the program. This program has gained momentum and is successfully addressing urgent needs in AIDS education and prevention. Over the next five years, the program will continue this momentum and address a new need - the urgency for infrastructure and expertise to deal with the scale up of the antiretroviral treatment- program.