Minimally Invasive Micro-Nanoscale Tools and Devices for Medicine

微创微纳米医学工具和设备

• 批准号: 7926326
• 负责人: David H Gracias
• 金额: $ 6.18万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7926326
• 关键词: Biopsy; Categories; Devices; Drug Delivery Systems; Endoscopy; Engineering; Goals; Human Engineering; Image; In Vitro; Laboratories; Medicine; Microsurgery; Motion; Operative Surgical Procedures; Pattern; Research; Retrieval; Structure; System; Telemetry; Tube; abstracting; base; hypodermic needle; implantation; in vivo; instrumentation; micro-total analysis system; miniaturize; minimally invasive; nanoscale; self assembly; tool

Minimally Invasive Micro-Nanoscale Tools and Devices for Medicine Category: 06 Instrumentation and Engineering Abstract We propose to develop a new class of minimally invasive micro-nanoscale surgical tools and biomedical devices using a new strategy developed in our laboratory that is based on the self- actuation and self-assembly of lithographically patterned templates. Recently, we fabricated the first-of-their-kind, mass producible, mobile grippers and demonstrated the capture and retrieval of microscale objects without batteries, wiring, or tethers. In contrast with present day endoscopy tools that utilize tethers (and hence are difficult to manipulate around corners and in coiled geometries), the mobile grippers were used to demonstrate the first tetherless, remotely guided, in vitro biopsy within a narrow tube. We plan to build on these preliminary results to develop an entire mobile and remotely actuated toolbox (including grippers, cutters and locomotors) for microsurgery. We have also engineered a new class of remote controlled containers for in vitro lab-on-a- chip applications and in vivo drug delivery. The devices are small enough to fit through a hypodermic needle, thereby facilitating minimally invasive implantation and guidance in hard to reach micro-spaces. We propose to advance the functionality of these self-loading miniaturized containers by incorporating modules for sensing, imaging and telemetry within them. Our research goals are unique in that we seek to utilize mechanisms for motion and assembly that are harnessed within the structure, obviating the need for external tethers. Hence, apart from being technologically relevant, these paradigms are intellectually stimulating as they also enable the possibility for autonomous control of miniaturized machine-based function in human engineered biomedical systems.

微创微纳米医学工具和设备

项目成果

Three dimensional nanofabrication using surface forces.

• DOI: 10.1021/la1013889
• 发表时间: 2010-11-02
• 期刊: Langmuir : the ACS journal of surfaces and colloids
• 作者: Cho JH;Azam A;Gracias DH
• 通讯作者: Gracias DH

Voltage-gated ion transport through semiconducting conical nanopores formed by metal nanoparticle-assisted plasma etching.

• DOI: 10.1021/nl300673r
• 发表时间: 2012-07-11
• 期刊: Nano letters
• 影响因子: 10.8
• 作者: James T;Kalinin YV;Chan CC;Randhawa JS;Gaevski M;Gracias DH
• 通讯作者: Gracias DH

Self-assembly of lithographically patterned nanoparticles.

• DOI: 10.1021/nl9022176
• 发表时间: 2009-12
• 期刊: Nano letters
• 影响因子: 10.8
• 作者: Cho JH;Gracias DH
• 通讯作者: Gracias DH

Biopsy with thermally-responsive untethered microtools.

• DOI: 10.1002/adma.201203348
• 发表时间: 2013-01-25
• 期刊: ADVANCED MATERIALS
• 影响因子: 29.4
• 作者: Gultepe, Evin;Randhawa, Jatinder S.;Kadam, Sachin;Yamanaka, Sumitaka;Selaru, Florin M.;Shin, Eun J.;Kalloo, Anthony N.;Gracias, David H.
• 通讯作者: Gracias, David H.

Biopsy using a magnetic capsule endoscope carrying, releasing, and retrieving untethered microgrippers.

• DOI: 10.1109/tbme.2013.2283369
• 发表时间: 2014-02
• 期刊: IEEE transactions on bio-medical engineering
• 作者: Yim S;Gultepe E;Gracias DH;Sitti M
• 通讯作者: Sitti M