IMMUNOLOGIC BASIS OF COW MILK-INDUCED HYPERSENSITIVITIES
牛奶引起的过敏症的免疫学基础
基本信息
- 批准号:7718105
- 负责人:
- 金额:$ 1.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-03-01 至 2009-02-28
- 项目状态:已结题
- 来源:
- 关键词:Abdominal PainAccountingActivated LymphocyteAcuteAge-MonthsAllergensAllergicAllergic ReactionAtopic DermatitisBindingBody Weight decreasedCattleCell membraneCellsChildComputer Retrieval of Information on Scientific Projects DatabaseCutaneousDehydrationDevelopmentDiarrheaDiseaseEdemaEnterocolitisErythemaExanthemaFailure to ThriveFoodFood HypersensitivityFundingGastroesophageal reflux diseaseGastrointestinal tract structureGrantHistamineHypersensitivityIgEImmunologicsInfantIngestionInstitutionLifeLocalizedLymphocyte antigenMediatingMediator of activation proteinMilkMilk HypersensitivityNauseaNewborn InfantPatientsReactionResearchResearch PersonnelResourcesSatiationSkinSourceSymptomsSyndromeTimeUnited States National Institutes of HealthUrticariaVasodilationVomitingWeekbasecytokineeosinophilic gastroenteritisexperiencefood allergengastrointestinalimmunopathologymast cell
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Cow milk is the most common cause of food allergy in the first year of life, with approximately 2.5% of newborns experiencing allergic reactions to cow milk during this time. The majority of children "outgrow" [become tolerant] their milk allergy in 3-4 years. The most common allergic symptoms involve the skin and gastrointestinal tract. IgE- and non-IgE-mediated mechanisms each appear to account for about one-half of milk hypersensitivity disorders in young children, with the majority of IgE-mediated reactions involving the skin and the majority of cell-mediated reactions involving the gastrointestinal tract. Two forms of IgE-mediated skin reactions have been associated with milk allergy. Acute urticaria is due to allergen-induced cross-linkage of mast cell membrane-bound IgE. Preformed mediators are released, i.e. histamine, leading to localized vasodilation and increased vasopermeability, which results in erythema and edema. Atopic dermatitis also has been associated with IgE-mediated mast cell activation with release of preformed mediators and newly generated cytokines. In addition, cutaneous lymphocyte antigen positive [CLA+] lymphocytes are activated by food allergen ingestion, which probably accounts for the development of the eczematous rash. A variety of cow milk-induced, non-IgE-mediated [presumably cell-mediated] gastrointestinal hypersensitivities have been described. Milk-induced Enterocolitis Syndrome most commonly presents in young infants between 1 week and 6 months of age as protracted vomiting and diarrhea, which not infrequently results in dehydration. Patient with milk-induced Allergic Eosinophilic Gastroenteritis [AEG] generally present with post-prandial nausea and abdominal pain, early satiety or food refusal, vomiting or retching, gastroesophageal reflux and weight loss or failure to thrive. The immunopathology of these two disorders is poorly understood.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Hugh A Sampson其他文献
Standardization of anti-asthma herbal formula MSSM-002 by HPLC chromatographic fingerprint
- DOI:
10.1016/s0091-6749(02)81886-3 - 发表时间:
2002-01-01 - 期刊:
- 影响因子:
- 作者:
Zhong-Mei Zou;Hugh A Sampson;Xiu-Min Li - 通讯作者:
Xiu-Min Li
The Chinese herbal formula, MSSM-002, can reverse the established Th2 phenotype, which is accompanied with down regulation of the th2 transcription factor GATA-3
- DOI:
10.1016/s0091-6749(02)81592-5 - 发表时间:
2002-01-01 - 期刊:
- 影响因子:
- 作者:
Xiu-Min Li;Ariel Teper;Zhong-Mei Zou;Kamal D Srivastava;Brian H Schofield;Hugh A Sampson - 通讯作者:
Hugh A Sampson
Detection of milk proteins in dry powder inhalers containing lactose
- DOI:
10.1016/s0091-6749(02)81924-8 - 发表时间:
2002-01-01 - 期刊:
- 影响因子:
- 作者:
Anna H Nowak-Wegrzyn;Ludmilla Bardina;Kirsten Beyer;Wayne G Shreffler;Hugh A Sampson - 通讯作者:
Hugh A Sampson
Effects of preparation methods on the allergenicity of peanut in a murine model of peanut-induced anaphylaxis
- DOI:
10.1016/s0091-6749(02)81676-1 - 发表时间:
2002-01-01 - 期刊:
- 影响因子:
- 作者:
Hayf Emeil Al-Mussawir;Kamal D Srivastava;Kirsten Beyer;Jin-Hua Li;Side Li;Wesley Burks;Gary A Bannon;Xiu-Min Li;Hugh A Sampson - 通讯作者:
Hugh A Sampson
Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study
重复肾上腺素给药时间以告知儿科过敏反应观察期:一项回顾性队列研究
- DOI:
10.1016/s2352-4642(25)00139-7 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:15.500
- 作者:
Timothy E Dribin;Hugh A Sampson;Yin Zhang;Stephanie Boyd;Nanhua Zhang;Kenneth A Michelson;Mark I Neuman;David C Brousseau;Rakesh D Mistry;Stephen B Freedman;Paul L Aronson;Kelly R Bergmann;Brittany Boswell;Sri S Chinta;Wee-Jhong Chua;Ari R Cohen;Joanna S Cohen;Alicia Daggett;Justin R Davis;Julia F Freeman;Seth Woolf - 通讯作者:
Seth Woolf
Hugh A Sampson的其他文献
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{{ truncateString('Hugh A Sampson', 18)}}的其他基金
MOUNT SINAI INSTITUTES FOR CLINICAL AND TRANSLATIONAL SCIENCES
西奈山临床和转化科学研究所
- 批准号:
8364989 - 财政年份:2011
- 资助金额:
$ 1.94万 - 项目类别:
Immunologic Responses to Cow's Milk Proteins in IgE-mediated Cow's Milk Allergy
IgE 介导的牛奶过敏中牛奶蛋白的免疫反应
- 批准号:
8034293 - 财政年份:2010
- 资助金额:
$ 1.94万 - 项目类别:
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