Childhood Development After Cochlear Implantation

项目总结 人工耳蜗术后儿童发育(CDaCI)的多点前瞻性研究 一大群不同的美国儿童植入人工耳蜗术(CI)。参与者最初是注册的， 2002至2004年间在六个儿科CI中心植入。参与者包括患有严重到 188例5岁前接受CI治疗的重度感音神经性耳聋患者及对照组 (n=97)听力正常的同龄人。独一无二的是，我们使用了一种“完整的”方法来检查 成果，包括：(A)听力学和语音识别；(B)口语和语音产生；(C) 亲子互动和认知、行为和社会功能；和(D)生活质量 卫生设施。配置项的成功取决于多个开发领域之间的复杂交互作用。 因此，这些目标是由假设驱动的，这些假设将CI后绩效的可变性与环境， 社会、干预和生物影响。这项多维度的研究为小说、 对沟通、社交和行为发展中差异来源的概括洞察力 影响长期结果。CDaCI研究以CI参与者到达时的最终提交结束 即将进入成年期。最终数据收集将评估与实现独立和 通过管理在线调查，成人角色、社会情绪功能和生活质量。这些 评估的目标是通过高中后经历遇到的相关挑战，并确定 影响CI受助者进入大学、工作场所和独立生活能力的日常生活因素。 我们还将能够计算这种手术干预的成本效益。CDaCI的研究发表在 独家跟踪20年来从儿童早期到 青春期，直到成年。在本意见书中，提出了以下五个目标： (I)检查成人角色和独立性、心理社会功能和HRQOL的成就 5岁前接受CI治疗的青少年和青壮年的全国队列； (2)评估重度至重度听力损失的终生社会代价和负担，并确定 在至少15年的后续行动中使用配置项的成本效用； (Iii)评估我们新的、针对CI的青少年HRQOL测量工具的心理测量学特性，以及 初露头角的成人； (Iv)确定使用CI的持续时间和干预选择，以促进实现正常的言语和 学术水平，并考察沟通技能素养与青少年之间的关系 成人结果；以及， (5)编制一个总数据库，纵向链接整个研究期间的数据，并发布 2002-2022年收集的CDaCI数据的未识别公共用途数据集。

PROJECT SUMMARY The Childhood Development after Cochlear Implantation (CDaCI) Study is a multisite, prospective investigation of a large, diverse cohort of US children with cochlear implants (CIs). Participants were originally enrolled and implanted between 2002 and 2004 at six pediatric CI centers. The participants include children with severe-to- profound sensorineural hearing loss who received a CI before 5 years of age (n=188) and a control group (n=97) of normally hearing age-mates. Uniquely, we have utilized a “whole child” approach to examine outcomes, including: (a) audiology and speech recognition; (b) spoken language and speech production; (c) parent-child interactions and cognitive, behavioral, and social functioning; and (d) quality of life (QoL) and health utility. Success with CIs depends on complex interactions between multiple domains of development. Accordingly, the aims are driven by hypotheses that relate variability in post-CI performance to environmental, social, interventional, and biological influences. This multidimensional study offers great potential for novel, generalizable insights into sources of variation in communicative, social, and behavioral development that affect long-term outcomes. The CDaCI Study concludes with this final submission as the CI participants reach emerging adulthood. Final data collection will assess outcomes related to attainment of independence and adult roles, socioemotional functioning, and QoL through the administration of online surveys. These assessments target relevant challenges encountered through the post-high school experience and identify daily life factors that affect the CI recipients' capacity to enter college, the workplace, and live independently. We also will be able to calculate the cost-effectiveness of this surgical intervention. The CDaCI Study is in the exclusive position to track 20 years of developmental outcomes stemming from early childhood to adolescence, through emerging adulthood. In this submission, the following five aims are addressed: (I) To examine the achievement of adult roles and independence, psychosocial functioning, and HRQoL in a national cohort of adolescents and young adults who received a CI by 5 years of age; (II) To evaluate the lifetime societal costs and burden of severe-to-profound hearing loss and determine the cost utility of CIs over at least 15 years of follow-up; (III) To evaluate the psychometric properties of our new, CI-specific HRQoL measure for adolescents and emerging adults; (IV) To identify duration of CI use and intervention choices that facilitate achieving normal verbal and academic levels, and to examine the relationship between communication skill attainment and young adult outcomes; and, (V) To compile a master database longitudinally linking data across the entire study period and release a de-identified public-use dataset of the CDaCI data collected from 2002-2022.