Development and validation of embedded micro wireless strain sensor array for in vivo characterization of contact stress distribution in hip replacement

嵌入式微型无线应变传感器阵列的开发和验证，用于髋关节置换术中接触应力分布的体内表征

• 批准号: 10244923
• 负责人: Fei Peng
• 金额: $ 25.58万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2021-08-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10244923
• 关键词: Animals; Bathing; Biomechanics; Cadaver; Centers of Research Excellence; Chemicals; Clinical Trials; Data; Development; Devices; Diagnostic radiologic examination; Dislocations; Elements; Environment; Failure; Future; Goals; Harvest; Head; Health; Hip Joint; Human; Implant; Joint Dislocation; Joint Prosthesis; Joints; Knee; Lasers; Lead; Ligaments; Limb structure; Location; Measurement; Measures; Mechanical Stress; Medial; Methods; Microfluidics; Modeling; Musculoskeletal; Operative Surgical Procedures; Orthopedic Surgery; Orthopedics; Oryctolagus cuniculus; Outcome; Outcomes Research; Performance; Positioning Attribute; Procedures; Replacement Arthroplasty; Research; Research Personnel; Resolution; Saline; Shoulder; Specimen; Stress; Surface; Surgeon; Temperature; Testing; Time; Total Hip Replacement; Translational Research; Validation; Wireless Technology; biomaterial compatibility; follow-up; hip replacement arthroplasty; improved; in vivo; innovation; mechanical properties; microsensor; novel; prevent; sensor; sensor technology; simulation; success; tool; ultra-high molecular weight polyethylene; virtual human

SUMMARY Total hip arthroplasty (THA) is one of the most widely performed orthopedic surgeries in the US. Unfortunately, many follow-up revisions are often expensive and ineffective. Many simulation studies show that the failures are caused by edge loading and excess stresses resulting from inappropriate component positions or size selections during surgeries. The lack of an in vivo stress distribution characterization method at the joint interface currently prevents the fundamental understanding of the effect of surgery factors such as the positioning and choice of implants on the THA outcome. Our goal is to develop embedded, micro wireless strain sensors for in vivo characterization of the biomechanical stress distribution and validate their usefulness in THA. The project will harvest our recent breakthroughs in development of embeddable microfluidic sensors that are highly sensitive to micro-strains. These sensors will be further developed into arrays and embedded into the UHMWPE insert for in vivo measurement of the stress distributions. The sensor arrays embedded in UNMWPE will be calibrated and validated using cadaver testing. We will also study the effect of the radiographic inclination angles and anteversion angles on the stress distributions at the contact interface of the hip joint. The underlying hypothesis is that the femoral/acetabular bearing surface stress distribution is strongly correlated with the positioning, and the quantitative correlation (once established) can be used to guide THA and improve its outcome. We will pursue three specific aims. Aim 1: Develop and calibrate micro wireless strain sensors embedded within UHMWPE. Aim 2: Validate the strain mapping capability of the sensor array embedded UHMWPE using cadaver testing and finite element modeling. Aim 3: Preliminarily evaluate the embedded strain sensors in animal studies. This research is innovative in that it will provide a precise, in vivo stress distribution characterization method at the hip joint interface, which is currently greatly needed but unavailable. This research is significant in that we will 1) Establish the fabrication method of the highly sensitive, micro-sized, biocompatible, embedded wireless strain sensors; 2) Enable the analysis of surface stress distribution with different implant positioning; 3) Provide a useful tool for future fundamental studies on the interrelated effects of other THA parameters, such as the component sizes and ligament tension, on the biomechanical environment at femoral head/UHMWPE insert interface. Providing a new tool for in vivo characterization of the stress distribution, this project integrates with the COBRE's research theme in virtual human trial to improve musculoskeletal health.

概括 总髋关节置换术（THA）是美国表现最广泛的骨科手术之一。很遗憾， 许多后续修订通常昂贵且无效。许多模拟研究表明失败 是由边缘负荷和不适当的组件位置或大小引起的过多压力引起的 手术期间的选择。关节缺乏体内应力分布表征方法 目前，界面阻止了对手术因素的影响（例如 植入物在结果上的定位和选择。我们的目标是开发嵌入式，微型无线 应变传感器，用于体内表征生物力学应力分布并验证其实用性 在tha。该项目将收获我们最近在嵌入可嵌入的微流体传感器开发方面的突破 对微晶体高度敏感的。这些传感器将进一步发展为阵列并嵌入 进入UHMWPE插入物，以进行应力分布的体内测量。传感器阵列嵌入 使用尸体测试将校准和验证UNMWPE。我们还将研究 放射线倾斜角度和在应力分布的接触界面的接触界面的接触界面 髋关节。潜在的假设是股骨/髋臼轴承表面应力分布强烈 与定位相关，并且可以使用定量相关性（一旦建立）来指导tha 并改善其结果。我们将追求三个具体目标。目标1：开发和校准微型无线 应变传感器嵌入UHMWPE中。 AIM 2：验证传感器阵列的应变映射能力 使用尸体测试和有限元建模嵌入UHMWPE。目标3：初步评估 动物研究中的嵌入式应变传感器。这项研究具有创新性，因为它将提供一个精确的体内 髋关节接口处的应力分布表征方法，目前非常需要，但是 不可用。这项研究很重要，因为我们将1）建立高度的制造方法 敏感，微型，生物相容性，嵌入式无线应变传感器； 2）启用表面分析 用不同植入物定位的应力分布； 3）为将来的基础研究提供了有用的工具 其他THA参数的相互关联影响，例如成分大小和韧带张力，对 股头/UHMWPE插入界面的生物力学环境。为体内提供新工具 压力分布的表征，该项目与毛绒的研究主题合成虚拟的主题 改善肌肉骨骼健康的人类试验。