Development and validation of embedded micro wireless strain sensor array for in vivo characterization of contact stress distribution in hip replacement
嵌入式微型无线应变传感器阵列的开发和验证,用于髋关节置换术中接触应力分布的体内表征
基本信息
- 批准号:10244923
- 负责人:
- 金额:$ 25.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-15 至 2021-08-02
- 项目状态:已结题
- 来源:
- 关键词:AnimalsBathingBiomechanicsCadaverCenters of Research ExcellenceChemicalsClinical TrialsDataDevelopmentDevicesDiagnostic radiologic examinationDislocationsElementsEnvironmentFailureFutureGoalsHarvestHeadHealthHip JointHumanImplantJoint DislocationJoint ProsthesisJointsKneeLasersLeadLigamentsLimb structureLocationMeasurementMeasuresMechanical StressMedialMethodsMicrofluidicsModelingMusculoskeletalOperative Surgical ProceduresOrthopedic SurgeryOrthopedicsOryctolagus cuniculusOutcomeOutcomes ResearchPerformancePositioning AttributeProceduresReplacement ArthroplastyResearchResearch PersonnelResolutionSalineShoulderSpecimenStressSurfaceSurgeonTemperatureTestingTimeTotal Hip ReplacementTranslational ResearchValidationWireless Technologybiomaterial compatibilityfollow-uphip replacement arthroplastyimprovedin vivoinnovationmechanical propertiesmicrosensornovelpreventsensorsensor technologysimulationsuccesstoolultra-high molecular weight polyethylenevirtual human
项目摘要
SUMMARY
Total hip arthroplasty (THA) is one of the most widely performed orthopedic surgeries in the US. Unfortunately,
many follow-up revisions are often expensive and ineffective. Many simulation studies show that the failures
are caused by edge loading and excess stresses resulting from inappropriate component positions or size
selections during surgeries. The lack of an in vivo stress distribution characterization method at the joint
interface currently prevents the fundamental understanding of the effect of surgery factors such as the
positioning and choice of implants on the THA outcome. Our goal is to develop embedded, micro wireless
strain sensors for in vivo characterization of the biomechanical stress distribution and validate their usefulness
in THA. The project will harvest our recent breakthroughs in development of embeddable microfluidic sensors
that are highly sensitive to micro-strains. These sensors will be further developed into arrays and embedded
into the UHMWPE insert for in vivo measurement of the stress distributions. The sensor arrays embedded in
UNMWPE will be calibrated and validated using cadaver testing. We will also study the effect of the
radiographic inclination angles and anteversion angles on the stress distributions at the contact interface of the
hip joint. The underlying hypothesis is that the femoral/acetabular bearing surface stress distribution is strongly
correlated with the positioning, and the quantitative correlation (once established) can be used to guide THA
and improve its outcome. We will pursue three specific aims. Aim 1: Develop and calibrate micro wireless
strain sensors embedded within UHMWPE. Aim 2: Validate the strain mapping capability of the sensor array
embedded UHMWPE using cadaver testing and finite element modeling. Aim 3: Preliminarily evaluate the
embedded strain sensors in animal studies. This research is innovative in that it will provide a precise, in vivo
stress distribution characterization method at the hip joint interface, which is currently greatly needed but
unavailable. This research is significant in that we will 1) Establish the fabrication method of the highly
sensitive, micro-sized, biocompatible, embedded wireless strain sensors; 2) Enable the analysis of surface
stress distribution with different implant positioning; 3) Provide a useful tool for future fundamental studies on
the interrelated effects of other THA parameters, such as the component sizes and ligament tension, on the
biomechanical environment at femoral head/UHMWPE insert interface. Providing a new tool for in vivo
characterization of the stress distribution, this project integrates with the COBRE's research theme in virtual
human trial to improve musculoskeletal health.
总结
全髋关节置换术(THA)是美国最广泛实施的骨科手术之一。不幸的是,
许多后续翻修手术往往费用昂贵且效果不佳。许多模拟研究表明,
由不适当的部件位置或尺寸引起的边缘载荷和过度应力引起
手术中的选择关节处缺乏体内应力分布表征方法
界面目前阻碍了对手术因素的影响的基本理解,
植入物的定位和选择对THA结局的影响。我们的目标是开发嵌入式微型无线
应变传感器,用于生物力学应力分布的体内表征,并验证其有用性
在THA。该项目将收获我们最近在嵌入式微流体传感器开发方面的突破
对微菌株高度敏感的细菌这些传感器将进一步发展成阵列并嵌入
用于体内测量应力分布。传感器阵列嵌入在
将利用尸体测试对联合国妇女和职业教育特派团进行校准和验证。我们亦会研究
X线倾斜角和前倾角对接触界面应力分布的影响
髋关节基本假设是股骨/髋臼关节面应力分布强烈
与定位相关,定量相关性(一旦建立)可用于指导THA
并改善其结果。我们将追求三个具体目标。目标1:开发和校准微型无线
应变传感器嵌入UHMWPE中。目标2:验证传感器阵列的应变映射能力
使用尸体测试和有限元建模植入UHMWPE。目标3:初步评估
植入应变传感器的动物实验这项研究是创新的,因为它将提供一个精确的,在体内
髋关节界面的应力分布表征方法,目前非常需要,但
不可用.本研究的意义在于:1)建立了高性能的半导体激光器的制造方法,
敏感的、微型的、生物相容的、嵌入式无线应变传感器; 2)能够分析表面
不同种植体位置的应力分布; 3)为将来的基础研究提供有用的工具,
其他THA参数的相互影响,如部件尺寸和韧带张力,
股骨头/UHMWPE衬垫界面的生物力学环境。提供了一种新的工具,
应力分布的表征,该项目与COBRE的虚拟研究主题相结合
改善肌肉骨骼健康的人体试验。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Fei Peng其他文献
Fei Peng的其他文献
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{{ truncateString('Fei Peng', 18)}}的其他基金
Novel Polymer-antibody Conjugates as Long-acting Therapeutics for Ocular Diseases
新型聚合物-抗体缀合物作为眼部疾病的长效治疗药物
- 批准号:
10760186 - 财政年份:2023
- 资助金额:
$ 25.58万 - 项目类别:
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