Development and validation of embedded micro wireless strain sensor array for in vivo characterization of contact stress distribution in hip replacement

嵌入式微型无线应变传感器阵列的开发和验证,用于髋关节置换术中接触应力分布的体内表征

基本信息

  • 批准号:
    10244923
  • 负责人:
  • 金额:
    $ 25.58万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-09-15 至 2021-08-02
  • 项目状态:
    已结题

项目摘要

SUMMARY Total hip arthroplasty (THA) is one of the most widely performed orthopedic surgeries in the US. Unfortunately, many follow-up revisions are often expensive and ineffective. Many simulation studies show that the failures are caused by edge loading and excess stresses resulting from inappropriate component positions or size selections during surgeries. The lack of an in vivo stress distribution characterization method at the joint interface currently prevents the fundamental understanding of the effect of surgery factors such as the positioning and choice of implants on the THA outcome. Our goal is to develop embedded, micro wireless strain sensors for in vivo characterization of the biomechanical stress distribution and validate their usefulness in THA. The project will harvest our recent breakthroughs in development of embeddable microfluidic sensors that are highly sensitive to micro-strains. These sensors will be further developed into arrays and embedded into the UHMWPE insert for in vivo measurement of the stress distributions. The sensor arrays embedded in UNMWPE will be calibrated and validated using cadaver testing. We will also study the effect of the radiographic inclination angles and anteversion angles on the stress distributions at the contact interface of the hip joint. The underlying hypothesis is that the femoral/acetabular bearing surface stress distribution is strongly correlated with the positioning, and the quantitative correlation (once established) can be used to guide THA and improve its outcome. We will pursue three specific aims. Aim 1: Develop and calibrate micro wireless strain sensors embedded within UHMWPE. Aim 2: Validate the strain mapping capability of the sensor array embedded UHMWPE using cadaver testing and finite element modeling. Aim 3: Preliminarily evaluate the embedded strain sensors in animal studies. This research is innovative in that it will provide a precise, in vivo stress distribution characterization method at the hip joint interface, which is currently greatly needed but unavailable. This research is significant in that we will 1) Establish the fabrication method of the highly sensitive, micro-sized, biocompatible, embedded wireless strain sensors; 2) Enable the analysis of surface stress distribution with different implant positioning; 3) Provide a useful tool for future fundamental studies on the interrelated effects of other THA parameters, such as the component sizes and ligament tension, on the biomechanical environment at femoral head/UHMWPE insert interface. Providing a new tool for in vivo characterization of the stress distribution, this project integrates with the COBRE's research theme in virtual human trial to improve musculoskeletal health.
概括 全髋关节置换术(THA)是美国实施最广泛的骨科手术之一。很遗憾, 许多后续修订往往成本高昂且效率低下。许多模拟研究表明,故障 由边缘负载和不适当的部件位置或尺寸引起的过大应力引起 手术时的选择。缺乏关节处的体内应力分布表征方法 目前,界面阻碍了对手术因素影响的基本理解,例如 植入物的定位和选择对 THA 结果的影响。我们的目标是开发嵌入式、微型无线 应变传感器用于生物力学应力分布的体内表征并验证其有用性 在THA中。该项目将收获我们近期在嵌入式微流控传感器开发方面取得的突破 对微应变高度敏感。这些传感器将进一步发展为阵列和嵌入式 插入 UHMWPE 插入物中,用于体内应力分布测量。传感器阵列嵌入 UNMWPE 将使用尸体测试进行校准和验证。我们还将研究其效果 射线照相倾角和前倾角对接触界面应力分布的影响 髋关节。基本假设是股骨/髋臼支撑表面应力分布强烈 与定位相关,并且定量相关性(一旦建立)可用于指导THA 并改善其结果。我们将追求三个具体目标。目标 1:开发和校准微型无线 嵌入 UHMWPE 内的应变传感器。目标 2:验证传感器阵列的应变映射能力 使用尸体测试和有限元建模嵌入 UHMWPE。目标 3:初步评估 在动物研究中嵌入应变传感器。这项研究的创新之处在于它将提供精确的体内 髋关节界面应力分布表征方法,目前非常需要,但 不可用。这项研究的意义在于我们将1)建立高度的制造方法 灵敏、微型、生物相容性、嵌入式无线应变传感器; 2) 启用表面分析 不同种植体位置的应力分布; 3)为未来的基础研究提供有用的工具 其他 THA 参数(例如组件尺寸和韧带张力)的相互关联的影响 股骨头/UHMWPE插入界面处的生物力学环境。提供体内新工具 应力分布的表征,该项目与 COBRE 的虚拟研究主题相结合 改善肌肉骨骼健康的人体试验。

项目成果

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Fei Peng其他文献

Fei Peng的其他文献

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{{ truncateString('Fei Peng', 18)}}的其他基金

Novel Polymer-antibody Conjugates as Long-acting Therapeutics for Ocular Diseases
新型聚合物-抗体缀合物作为眼部疾病的长效治疗药物
  • 批准号:
    10760186
  • 财政年份:
    2023
  • 资助金额:
    $ 25.58万
  • 项目类别:

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