Core A: Administrative and Professional Development Core

行政和专业发展核心是由露西廖和克利福德罗森， COBRE计划的主要研究人员。作为COBRE计划的领导者，我们的目标是 支持科学生产力和合作，加强和协调我们的研究基础设施， 寻求和扩大科学专业知识，并积极监督和监测专业发展 程序.为了实现这些目标，该核心将1）在该领域提供领导和科学专业知识 间充质组织分化和信号传导以及代谢健康和疾病中的神经相互作用， 2)建立一个由初级研究人员组成的核心研究小组，由科学和职业支持， 导师，3）加强科学核心设施，以支持最先进的研究方法，以及4） 管理合作试点项目计划。COBRE由四个主题相关的项目组成， 每个项目负责人都有两名资深的研究导师，他们都是该领域的专家。其他咨询 网络包括一个由科学专家和经验丰富的计划组成的外部咨询委员会， 领导人，以及由生物医学研究领域的科学专家和利益相关者组成的指导委员会 在缅因州。我们在缅因州医疗中心的临床同事将提供翻译机会， 代谢健康和疾病领域临床挑战的重要观点和指导。到 为了支持我们的初级调查员和核心设施领导人的发展，我们致力于 专业发展资源，以支持课程，研讨会和创新的科学家离开 促进合作和培训的计划。所有这些战略将支持项目和核心领导人， 达到我们中心内明确规定的基准。一个强有力的评估计划将有助于 促进积极的长期成果。该核心和总体方案的具体目标是： 具体目标1。提供领导、治理和咨询网络，以建立新的科学 计划在间充质祖细胞生物学和神经信号，以获得新的见解， 代谢健康和疾病的潜在机制。 具体目标2。提供项目和导师支持，以启动有前途的初级职业 研究人员在这个科学计划，并帮助确保他们的长期科学成功的独立 研究人员 具体目标3。增强我们核心设施的能力，以支持我们的COBRE调查人员， 其他机构和外部研究人员，并鼓励创新的研究方法和新的 合作。 具体目标4。加强我们现有的、COBRE-supported试点项目计划， 与代谢疾病有关的机会。

The Administrative and Professional Development Core is led by Lucy Liaw and Clifford Rosen, the Principal Investigators of this COBRE program. Our goals as leaders of this COBRE program are to foster and support scientific productivity and collaboration, enhance and coordinate our research infrastructure, seek out and expand scientific expertise, and actively oversee and monitor a professional development program. To accomplish these goals, this Core will 1) provide leadership and scientific expertise in the area of mesenchymal tissue differentiation and signaling and neural interactions in metabolic health and disease, 2) establish a core research group consisting of junior investigators supported by scientific and career mentors, 3) enhance scientific core facilities to support state-of-the-art research methodologies, and 4) administer a collaborative pilot project program. The COBRE consists of four thematically linked projects, and each project leader has two senior research mentors who are experts in the field. Additional advisory networks include an External Advisory Committee consisting of scientific experts and experienced program leaders, and a Steering Committee composed of scientific experts and stakeholders in biomedical research in Maine. Our clinical colleagues at Maine Medical Center will provide translational opportunities and important perspective and guidance on clinical challenges in the areas of metabolic health and disease. To support the advancement of our junior investigators and core facility leaders, we have dedicated professional development resources to support courses, workshops, and an innovative scientist leave program to foster collaboration and training. All of these strategies will support project and core leaders in achieving the benchmarks that are clearly defined within our Center. A robust evaluation program will help promote positive long-term outcomes. The specific aims of this Core and the overall program are: Specific Aim 1. Provide the leadership, governance, and advisory network to establish a new scientific program in mesenchymal progenitor cell biology and neural signaling to gain novel insights into the mechanisms underlying metabolic health and disease. Specific Aim 2. Provide project and mentorship support to launch the careers of promising junior investigators within this scientific program and help ensure their long-term scientific success as independent researchers. Specific Aim 3. Enhance the capabilities of our core facilities to support our COBRE investigators and other institutional and external researchers, and to stimulate innovative research methodologies and new collaborations. Specific Aim 4. Enhance our existing, COBRE-supported pilot project programs to focus on translational opportunities related to metabolic disease.