Phase II COBRE in Mesenchymal and Neural Regulation of Metabolic Networks

COBRE 代谢网络间充质和神经调节的 II 期研究

基本信息

  • 批准号:
    10711692
  • 负责人:
  • 金额:
    $ 258万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-09-01 至 2028-08-31
  • 项目状态:
    未结题

项目摘要

Overall Program (L. Liaw PD/PI) MaineHealth Institute for Research initiated a Phase I COBRE in Mesenchymal and Neural Regulation of Metabolic Networks (COBRE in Metabolic Networks) in 2017, directed by Lucy Liaw PhD, Faculty Scientist and Professor at MaineHealth. Our Center in Phase I developed a critical mass of investigators with biomedical research interests in metabolic health and disease, focusing on adipose tissue, bone and skeletal biology, and environmental, neural, and pharmacological inputs that regulate these tissues. Our COBRE also supported three scientific core facilities – Physiology, Histopathology, and Proteomics and Lipidomics cores. These scientific core facilities provide outstanding services, and have responsibility for maintaining state-of-the-art technologies in their respective areas by updating technology, equipment, and maintaining current knowledge. In addition, scientific core facilities are responsible for the training of staff, and assisting in experimental design, project implementation and data analysis. We established a robust mentoring network for our junior investigators, and engaged an external advisory committee to evaluate projects, cores, and our overall Center. Our investment in Phase I COBRE projects and pilot projects thus far has directly yielded six NIH R01 awards (including funding of the original four junior investigator project leads) with seven COBRE members, one NSF CAREER award, one NIH S10 instrumentation grant, and one foundation research grant. Two COBRE members also mentor PhD students who were awarded NIH F31 fellowships during this time. In year four of Phase I, we held a national faculty recruitment that yielded two outstanding new junior investigators who joined our COBRE; one in August 2021 (Matt Lynes PhD), and one in August 2022 (Ziru Li PhD). In addition to Drs. Lynes and Li, Phase II includes support for a third new junior investigator project lead, Dr. Isha Agarwal. These new project leads bring expertise in thermogenic adipocytes, a gut-bone signaling axis, and impact of night shift work on diabetes risk in pregnant women. Our Phase II program will build upon our successful leadership, mentorship and professional development model. We will focus on expanding our portfolio of research and scientific resources under the guidance of an Advisory Committee. Goals for Phase II of this COBRE in Metabolic Networks are: 1) Provide leadership to evolve a robust Center infrastructure including administrative, fiscal and scientific management to support growth of collaborative research and resources in metabolic health and disease, 2) Support career advancement for COBRE investigators and alumni, 3) Maintain high quality shared scientific resources, and 4) Build a diverse research community that is guided by principles of diversity, inclusion, and equity. Successful achievement of these goals will support professional development of promising junior investigators while expanding the use of well-regarded scientific shared research resources, which are already highly utilized by a researcher user base throughout the country.
整体课程(L. law PD/PI)

项目成果

期刊论文数量(22)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The role of Zfp467 in mediating the pro-osteogenic and anti-adipogenic effects on bone and bone marrow niche.
  • DOI:
    10.1016/j.bone.2020.115832
  • 发表时间:
    2021-03
  • 期刊:
  • 影响因子:
    4.1
  • 作者:
    Le PT;Liu H;Alabdulaaly L;Vegting Y;Calle IL;Gori F;Lanske B;Baron R;Rosen CJ
  • 通讯作者:
    Rosen CJ
Corrigendum: Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype.
  • DOI:
    10.1038/srep46791
  • 发表时间:
    2017-05-02
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    He Q;Jing H;Liaw L;Gower L;Vary C;Hua S;Yang X
  • 通讯作者:
    Yang X
Dynamic interplay between bone and multiple myeloma: emerging roles of the osteoblast.
  • DOI:
    10.1016/j.bone.2015.02.021
  • 发表时间:
    2015-06
  • 期刊:
  • 影响因子:
    4.1
  • 作者:
    Reagan MR;Liaw L;Rosen CJ;Ghobrial IM
  • 通讯作者:
    Ghobrial IM
Energy Metabolism of Bone.
骨骼的能量代谢。
  • DOI:
    10.1177/0192623317737065
  • 发表时间:
    2017-10
  • 期刊:
  • 影响因子:
    1.5
  • 作者:
    Motyl KJ;Guntur AR;Carvalho AL;Rosen CJ
  • 通讯作者:
    Rosen CJ
Pericytes as the Orchestrators of Vasculature and Adipogenesis.
  • DOI:
    10.3390/genes15010126
  • 发表时间:
    2024-01-19
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
  • 通讯作者:
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Lucy Liaw其他文献

Lucy Liaw的其他文献

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{{ truncateString('Lucy Liaw', 18)}}的其他基金

Enhancing research training for Maine Track / Tufts medical students
加强缅因田径/塔夫茨医学院学生的研究培训
  • 批准号:
    10555468
  • 财政年份:
    2023
  • 资助金额:
    $ 258万
  • 项目类别:
Regulation of arterial phenotype by perivascular adipose tissue in cardiometabolic disease
心脏代谢疾病中血管周围脂肪组织对动脉表型的调节
  • 批准号:
    9495408
  • 财政年份:
    2018
  • 资助金额:
    $ 258万
  • 项目类别:
Regulation of arterial phenotype by perivascular adipose tissue in cardiometabolic disease
心脏代谢疾病中血管周围脂肪组织对动脉表型的调节
  • 批准号:
    9977874
  • 财政年份:
    2018
  • 资助金额:
    $ 258万
  • 项目类别:
Regulation of arterial phenotype by perivascular adipose tissue in cardiometabolic disease
心脏代谢疾病中血管周围脂肪组织对动脉表型的调节
  • 批准号:
    10443027
  • 财政年份:
    2018
  • 资助金额:
    $ 258万
  • 项目类别:
Regulation of arterial phenotype by perivascular adipose tissue in cardiometabolic disease
心脏代谢疾病中血管周围脂肪组织对动脉表型的调节
  • 批准号:
    10231190
  • 财政年份:
    2018
  • 资助金额:
    $ 258万
  • 项目类别:
Regulation of arterial phenotype by perivascular adipose tissue in cardiometabolic disease
心脏代谢疾病中血管周围脂肪组织对动脉表型的调节
  • 批准号:
    10610480
  • 财政年份:
    2018
  • 资助金额:
    $ 258万
  • 项目类别:
Mesenchymal and Neural Regulation of Metabolic Networks
代谢网络的间充质和神经调节
  • 批准号:
    10246808
  • 财政年份:
    2017
  • 资助金额:
    $ 258万
  • 项目类别:
COBRE in Mesenchymal and Neural Regulation of Metabolic Networks - Metabolic Phenotyping Equipment
COBRE 在代谢网络的间充质和神经调节中的作用 - 代谢表型设备
  • 批准号:
    10396172
  • 财政年份:
    2017
  • 资助金额:
    $ 258万
  • 项目类别:
Lewy Body Dementia and Alpha Synuclein Induced Changes in Adipose Tissue
路易体痴呆和α突触核蛋白引起脂肪组织的变化
  • 批准号:
    10117901
  • 财政年份:
    2017
  • 资助金额:
    $ 258万
  • 项目类别:
Core A: Administrative and Professional Development Core
核心 A:行政和专业发展核心
  • 批准号:
    10246818
  • 财政年份:
    2017
  • 资助金额:
    $ 258万
  • 项目类别:

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Recruitment of brown adipocytes in visceral white adipose tissue by fibroblast growth factor 8b
成纤维细胞生长因子 8b 将棕色脂肪细胞募集到内脏白色脂肪组织中
  • 批准号:
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Enhancing Energy Expending Adipocytes in White Adipose Tissue
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食物源性因子在白色脂肪组织中诱导棕色样脂肪细胞
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  • 财政年份:
    2014
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    $ 258万
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    Grant-in-Aid for Scientific Research (C)
WAT-on-a-chip - Development of a micofluidic, microphysiologic in vitro adipose tissue model for high-throughput drug screening based on hiPSC-derived adipocytes.
WAT-on-a-chip - 开发微流体、微生理体外脂肪组织模型,用于基于 hiPSC 衍生脂肪细胞的高通量药物筛选。
  • 批准号:
    257256526
  • 财政年份:
    2014
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Enhancing Energy Expending Adipocytes in White Adipose Tissue
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  • 批准号:
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  • 财政年份:
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增强白色脂肪组织中的能量消耗脂肪细胞
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  • 财政年份:
    2013
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Enhancing Energy Expending Adipocytes in White Adipose Tissue
增强白色脂肪组织中的能量消耗脂肪细胞
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运动训练对白色脂肪组织内脂肪细胞形成的影响
  • 批准号:
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  • 财政年份:
    2011
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白色脂肪组织中棕色脂肪细胞出现机制的研究
  • 批准号:
    21780261
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    2009
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  • 批准号:
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