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Phase II COBRE in Mesenchymal and Neural Regulation of Metabolic Networks

COBRE 代谢网络间充质和神经调节的 II 期研究

基本信息

批准号：
10711692
负责人：
Lucy Liaw
金额：
$ 258万
依托单位：
MAINEHEALTH
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10711692
关键词：
Achievement Adipocytes Adipose tissue Advisory Committees Area Award Basic Science Biochemical Pathway Biology Biomedical Research Bone Marrow Cardiovascular system Career Mobility Caregivers Caring Centers of Research Excellence Chronic Clinical Research Clinical Sciences Clinical Trials Collaborations Communities Complement Core Facility Country Data Analyses Data Analytics Development Diabetes Mellitus Disease Doctor of Philosophy Education Equipment Experimental Designs Faculty Faculty Recruitment Feedback Fellowship Fostering Foundations Funding Goals Grant Growth Health Healthcare Histopathology Hospitals Infrastructure Institution Investments Knowledge Lead Leadership Maine Medical center Mentors Mentorship Mesenchymal Metabolic Metabolic Diseases Metabolism Microscopy Mission Modeling Morbidity - disease rate New England Obesity Osteoporosis Pain Patient Care Performance Phase Physiology Pilot Projects Policies Population Research Predisposition Pregnancy Pregnant Women Principal Investigator Productivity Professional Education Program Evaluation Proteomics Public Health Request for Applications Research Research Institute Research Personnel Research Project Grants Resource Sharing Resources Scientist Sensory Services Signal Transduction Smooth Muscle Student recruitment Talents Technology Time Tissues Training Training and Education Translational Research United States National Institutes of Health Universities Update Work acute care arm bariatric surgery base bone bone loss career development diabetes risk diversity and inclusion doctoral student equity, diversity, and inclusion improved instrumentation interest lipidomics member model development mortality neural neuroregulation pharmacologic population health professor programs recruit responsible research conduct rural disparities shift work skeletal student mentoring success synergism

项目摘要

Overall Program (L. Liaw PD/PI) MaineHealth Institute for Research initiated a Phase I COBRE in Mesenchymal and Neural Regulation of Metabolic Networks (COBRE in Metabolic Networks) in 2017, directed by Lucy Liaw PhD, Faculty Scientist and Professor at MaineHealth. Our Center in Phase I developed a critical mass of investigators with biomedical research interests in metabolic health and disease, focusing on adipose tissue, bone and skeletal biology, and environmental, neural, and pharmacological inputs that regulate these tissues. Our COBRE also supported three scientific core facilities – Physiology, Histopathology, and Proteomics and Lipidomics cores. These scientific core facilities provide outstanding services, and have responsibility for maintaining state-of-the-art technologies in their respective areas by updating technology, equipment, and maintaining current knowledge. In addition, scientific core facilities are responsible for the training of staff, and assisting in experimental design, project implementation and data analysis. We established a robust mentoring network for our junior investigators, and engaged an external advisory committee to evaluate projects, cores, and our overall Center. Our investment in Phase I COBRE projects and pilot projects thus far has directly yielded six NIH R01 awards (including funding of the original four junior investigator project leads) with seven COBRE members, one NSF CAREER award, one NIH S10 instrumentation grant, and one foundation research grant. Two COBRE members also mentor PhD students who were awarded NIH F31 fellowships during this time. In year four of Phase I, we held a national faculty recruitment that yielded two outstanding new junior investigators who joined our COBRE; one in August 2021 (Matt Lynes PhD), and one in August 2022 (Ziru Li PhD). In addition to Drs. Lynes and Li, Phase II includes support for a third new junior investigator project lead, Dr. Isha Agarwal. These new project leads bring expertise in thermogenic adipocytes, a gut-bone signaling axis, and impact of night shift work on diabetes risk in pregnant women. Our Phase II program will build upon our successful leadership, mentorship and professional development model. We will focus on expanding our portfolio of research and scientific resources under the guidance of an Advisory Committee. Goals for Phase II of this COBRE in Metabolic Networks are: 1) Provide leadership to evolve a robust Center infrastructure including administrative, fiscal and scientific management to support growth of collaborative research and resources in metabolic health and disease, 2) Support career advancement for COBRE investigators and alumni, 3) Maintain high quality shared scientific resources, and 4) Build a diverse research community that is guided by principles of diversity, inclusion, and equity. Successful achievement of these goals will support professional development of promising junior investigators while expanding the use of well-regarded scientific shared research resources, which are already highly utilized by a researcher user base throughout the country.

整体课程（L. law PD/PI）

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The role of Zfp467 in mediating the pro-osteogenic and anti-adipogenic effects on bone and bone marrow niche.

DOI：
10.1016/j.bone.2020.115832
发表时间：
2021-03
期刊：
Bone
影响因子：
4.1
作者：
Le PT;Liu H;Alabdulaaly L;Vegting Y;Calle IL;Gori F;Lanske B;Baron R;Rosen CJ
通讯作者：
Rosen CJ

Corrigendum: Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype.