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Phase II COBRE in Mesenchymal and Neural Regulation of Metabolic Networks

COBRE 代谢网络间充质和神经调节的 II 期研究

基本信息

批准号：
10711692
负责人：
Lucy Liaw
金额：
$ 258万
依托单位：
MAINEHEALTH
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10711692
关键词：
Achievement Adipocytes Adipose tissue Advisory Committees Area Award Basic Science Biochemical Pathway Biology Biomedical Research Bone Marrow Cardiovascular system Career Mobility Caregivers Caring Centers of Research Excellence Chronic Clinical Research Clinical Sciences Clinical Trials Collaborations Communities Complement Core Facility Country Data Analyses Data Analytics Development Diabetes Mellitus Disease Doctor of Philosophy Education Equipment Experimental Designs Faculty Faculty Recruitment Feedback Fellowship Fostering Foundations Funding Goals Grant Growth Health Healthcare Histopathology Hospitals Infrastructure Institution Investments Knowledge Lead Leadership Maine Medical center Mentors Mentorship Mesenchymal Metabolic Metabolic Diseases Metabolism Microscopy Mission Modeling Morbidity - disease rate New England Obesity Osteoporosis Pain Patient Care Performance Phase Physiology Pilot Projects Policies Population Research Predisposition Pregnancy Pregnant Women Principal Investigator Productivity Professional Education Program Evaluation Proteomics Public Health Request for Applications Research Research Institute Research Personnel Research Project Grants Resource Sharing Resources Scientist Sensory Services Signal Transduction Smooth Muscle Student recruitment Talents Technology Time Tissues Training Training and Education Translational Research United States National Institutes of Health Universities Update Work acute care arm bariatric surgery base bone bone loss career development diabetes risk diversity and inclusion doctoral student equity, diversity, and inclusion improved instrumentation interest lipidomics member model development mortality neural neuroregulation pharmacologic population health professor programs recruit responsible research conduct rural disparities shift work skeletal student mentoring success synergism

项目摘要

Overall Program (L. Liaw PD/PI) MaineHealth Institute for Research initiated a Phase I COBRE in Mesenchymal and Neural Regulation of Metabolic Networks (COBRE in Metabolic Networks) in 2017, directed by Lucy Liaw PhD, Faculty Scientist and Professor at MaineHealth. Our Center in Phase I developed a critical mass of investigators with biomedical research interests in metabolic health and disease, focusing on adipose tissue, bone and skeletal biology, and environmental, neural, and pharmacological inputs that regulate these tissues. Our COBRE also supported three scientific core facilities – Physiology, Histopathology, and Proteomics and Lipidomics cores. These scientific core facilities provide outstanding services, and have responsibility for maintaining state-of-the-art technologies in their respective areas by updating technology, equipment, and maintaining current knowledge. In addition, scientific core facilities are responsible for the training of staff, and assisting in experimental design, project implementation and data analysis. We established a robust mentoring network for our junior investigators, and engaged an external advisory committee to evaluate projects, cores, and our overall Center. Our investment in Phase I COBRE projects and pilot projects thus far has directly yielded six NIH R01 awards (including funding of the original four junior investigator project leads) with seven COBRE members, one NSF CAREER award, one NIH S10 instrumentation grant, and one foundation research grant. Two COBRE members also mentor PhD students who were awarded NIH F31 fellowships during this time. In year four of Phase I, we held a national faculty recruitment that yielded two outstanding new junior investigators who joined our COBRE; one in August 2021 (Matt Lynes PhD), and one in August 2022 (Ziru Li PhD). In addition to Drs. Lynes and Li, Phase II includes support for a third new junior investigator project lead, Dr. Isha Agarwal. These new project leads bring expertise in thermogenic adipocytes, a gut-bone signaling axis, and impact of night shift work on diabetes risk in pregnant women. Our Phase II program will build upon our successful leadership, mentorship and professional development model. We will focus on expanding our portfolio of research and scientific resources under the guidance of an Advisory Committee. Goals for Phase II of this COBRE in Metabolic Networks are: 1) Provide leadership to evolve a robust Center infrastructure including administrative, fiscal and scientific management to support growth of collaborative research and resources in metabolic health and disease, 2) Support career advancement for COBRE investigators and alumni, 3) Maintain high quality shared scientific resources, and 4) Build a diverse research community that is guided by principles of diversity, inclusion, and equity. Successful achievement of these goals will support professional development of promising junior investigators while expanding the use of well-regarded scientific shared research resources, which are already highly utilized by a researcher user base throughout the country.

整体方案（L。Liaw PD/PI） MaineHealth研究所启动了一项I期COBRE，用于间质和神经调节，代谢网络（COBRE在代谢网络）在2017年，由露西廖博士，教师科学家和 MaineHealth的教授我们的中心在第一阶段开发了一个关键质量的研究人员与生物医学在代谢健康和疾病的研究兴趣，重点是脂肪组织，骨和骨骼生物学，环境，神经和药理学输入，调节这些组织。我们的COBRE还支持三个科学核心设施-生理学，组织学，蛋白质组学和脂质组学核心。这些科学的核心设施提供卓越的服务，并有责任保持最先进的水平通过更新技术、设备和保持现有知识，在各自的领域发展技术。此外，科学核心设施负责培训工作人员，并协助实验设计，项目实施和数据分析。我们为我们的初级员工建立了一个强大的指导网络，调查员，并聘请了一个外部咨询委员会来评估项目，核心和我们的整体中心。迄今为止，我们对第一阶段COBRE项目和试点项目的投资已直接获得六项NIH R 01奖项（包括最初四名初级研究员项目负责人的资金），七名COBRE成员，一名NSF成员，职业奖，一个NIH S10仪器补助金，一个基金会研究补助金。两个眼镜蛇成员还指导在此期间获得NIH F31奖学金的博士生。在第四年，第一阶段，我们举行了一次全国性的教师招聘，产生了两名杰出的新初级调查员，他们加入了我们的团队。我们的COBRE;一个在2021年8月（Matt Lynes博士），一个在2022年8月（Ziru Li博士）。除了博士。 Lynes和Li，第二阶段包括对第三位新的初级研究员项目负责人Isha Agarwal博士的支持。这些新的项目负责人带来了产热脂肪细胞、肠骨信号轴和夜间影响方面的专业知识轮班工作对孕妇患糖尿病风险的影响。我们的第二阶段计划将建立在我们成功的领导，导师制和专业发展模式。我们将专注于扩大我们的研究组合，在咨询委员会的指导下，COBRE第二阶段的目标代谢网络是：1）提供领导，发展一个强大的中心基础设施，包括行政，财政和科学管理，以支持代谢健康领域合作研究和资源的增长 2）支持COBRE研究人员和校友的职业发展，3）保持高质量共享科学资源，4）建立一个以多样性原则为指导的多元化研究社区，包容和公平。这些目标的成功实现将支持专业发展，有前途的初级研究人员，同时扩大使用备受好评的科学共享研究资源，这已经被全国各地的研究人员用户群高度利用。

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The role of Zfp467 in mediating the pro-osteogenic and anti-adipogenic effects on bone and bone marrow niche.

DOI：
10.1016/j.bone.2020.115832
发表时间：
2021-03
期刊：
Bone
影响因子：
4.1
作者：
Le PT;Liu H;Alabdulaaly L;Vegting Y;Calle IL;Gori F;Lanske B;Baron R;Rosen CJ
通讯作者：
Rosen CJ

Corrigendum: Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype.