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Phase II COBRE in Mesenchymal and Neural Regulation of Metabolic Networks

COBRE 代谢网络间充质和神经调节的 II 期研究

基本信息

批准号：
10711692
负责人：
Lucy Liaw
金额：
$ 258万
依托单位：
MAINEHEALTH
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10711692
关键词：
Achievement Adipocytes Adipose tissue Advisory Committees Area Award Basic Science Biochemical Pathway Biology Biomedical Research Bone Marrow Cardiovascular system Career Mobility Caregivers Caring Centers of Research Excellence Chronic Clinical Research Clinical Sciences Clinical Trials Collaborations Communities Complement Core Facility Country Data Analyses Data Analytics Development Diabetes Mellitus Disease Doctor of Philosophy Education Equipment Experimental Designs Faculty Faculty Recruitment Feedback Fellowship Fostering Foundations Funding Goals Grant Growth Health Healthcare Histopathology Hospitals Infrastructure Institution Investments Knowledge Lead Leadership Maine Medical center Mentors Mentorship Mesenchymal Metabolic Metabolic Diseases Metabolism Microscopy Mission Modeling Morbidity - disease rate New England Obesity Osteoporosis Pain Patient Care Performance Phase Physiology Pilot Projects Policies Population Research Predisposition Pregnancy Pregnant Women Principal Investigator Productivity Professional Education Program Evaluation Proteomics Public Health Request for Applications Research Research Institute Research Personnel Research Project Grants Resource Sharing Resources Scientist Sensory Services Signal Transduction Smooth Muscle Student recruitment Talents Technology Time Tissues Training Training and Education Translational Research United States National Institutes of Health Universities Update Work acute care arm bariatric surgery base bone bone loss career development diabetes risk diversity and inclusion doctoral student equity, diversity, and inclusion improved instrumentation interest lipidomics member model development mortality neural neuroregulation pharmacologic population health professor programs recruit responsible research conduct rural disparities shift work skeletal student mentoring success synergism

项目摘要

Overall Program (L. Liaw PD/PI) MaineHealth Institute for Research initiated a Phase I COBRE in Mesenchymal and Neural Regulation of Metabolic Networks (COBRE in Metabolic Networks) in 2017, directed by Lucy Liaw PhD, Faculty Scientist and Professor at MaineHealth. Our Center in Phase I developed a critical mass of investigators with biomedical research interests in metabolic health and disease, focusing on adipose tissue, bone and skeletal biology, and environmental, neural, and pharmacological inputs that regulate these tissues. Our COBRE also supported three scientific core facilities – Physiology, Histopathology, and Proteomics and Lipidomics cores. These scientific core facilities provide outstanding services, and have responsibility for maintaining state-of-the-art technologies in their respective areas by updating technology, equipment, and maintaining current knowledge. In addition, scientific core facilities are responsible for the training of staff, and assisting in experimental design, project implementation and data analysis. We established a robust mentoring network for our junior investigators, and engaged an external advisory committee to evaluate projects, cores, and our overall Center. Our investment in Phase I COBRE projects and pilot projects thus far has directly yielded six NIH R01 awards (including funding of the original four junior investigator project leads) with seven COBRE members, one NSF CAREER award, one NIH S10 instrumentation grant, and one foundation research grant. Two COBRE members also mentor PhD students who were awarded NIH F31 fellowships during this time. In year four of Phase I, we held a national faculty recruitment that yielded two outstanding new junior investigators who joined our COBRE; one in August 2021 (Matt Lynes PhD), and one in August 2022 (Ziru Li PhD). In addition to Drs. Lynes and Li, Phase II includes support for a third new junior investigator project lead, Dr. Isha Agarwal. These new project leads bring expertise in thermogenic adipocytes, a gut-bone signaling axis, and impact of night shift work on diabetes risk in pregnant women. Our Phase II program will build upon our successful leadership, mentorship and professional development model. We will focus on expanding our portfolio of research and scientific resources under the guidance of an Advisory Committee. Goals for Phase II of this COBRE in Metabolic Networks are: 1) Provide leadership to evolve a robust Center infrastructure including administrative, fiscal and scientific management to support growth of collaborative research and resources in metabolic health and disease, 2) Support career advancement for COBRE investigators and alumni, 3) Maintain high quality shared scientific resources, and 4) Build a diverse research community that is guided by principles of diversity, inclusion, and equity. Successful achievement of these goals will support professional development of promising junior investigators while expanding the use of well-regarded scientific shared research resources, which are already highly utilized by a researcher user base throughout the country.

总体计划(L.Liw PD/PI) MaineHealth研究所启动了间充质和神经调节的I期研究 2017年代谢网络(代谢网络中的Cobre)，由Lucy Liw博士指导，教授科学家和 MaineHealth的教授。我们的第一阶段中心发展了一批具有生物医学知识的研究人员对代谢健康和疾病的研究兴趣，重点是脂肪组织、骨骼和骨骼生物学，以及调节这些组织的环境、神经和药物输入。我们的科布雷也支持三个科学核心设施-生理学、组织病理学、蛋白质组学和脂质组学核心。这些科学核心设施提供卓越的服务，并有责任保持最先进的通过更新技术、设备和保持最新知识，在各自的领域内改进技术。此外，科学核心设施负责培训工作人员，并协助进行实验设计，项目实施和数据分析。我们为我们的孩子建立了一个强大的指导网络并聘请了一个外部咨询委员会来评估项目、核心和我们整个中心。到目前为止，我们对Cobre第一期项目和试点项目的投资直接产生了六个NIH R01奖项 (包括资助最初的四名初级调查员项目负责人)与七名Cobre成员，一名国家科学基金会职业奖，一项NIH S10仪器设备资助，一项基金会研究资助。两只科布雷会员还指导在此期间获得NIH F31奖学金的博士生。年的第四年第一阶段，我们举行了一次全国教师招聘，产生了两名优秀的新初级调查人员我们的Cobre；一个在2021年8月(Matt Lynes博士)，一个在2022年8月(Ziru Li博士)。除了戴维斯博士。莱恩斯和李，第二阶段包括支持第三位新的初级调查员项目负责人伊莎·阿加瓦尔博士。这些新的项目领导带来了在生热脂肪细胞、肠道-骨骼信号轴和夜间影响方面的专业知识在孕妇糖尿病风险方面轮班工作。我们的第二阶段计划将建立在我们成功的领导力基础上，导师制和专业发展模式。我们将专注于扩大我们的研究和在咨询委员会的指导下提供科学资源。此Cobre第二阶段的目标是代谢网络是：1)提供领导以发展强大的中心基础设施，包括管理、财政和科学管理，以支持代谢健康领域合作研究和资源的增长和疾病，2)支持Cobre研究人员和校友的职业发展，3)保持高质量共享科学资源，以及4)建立一个以多样性原则为指导的多样化研究社区，包容性和公平性。这些目标的成功实现将支持职业发展有前途的初级研究人员，同时扩大对备受好评的科学共享研究资源的使用，它已经被全国各地的研究人员用户群高度利用。

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The role of Zfp467 in mediating the pro-osteogenic and anti-adipogenic effects on bone and bone marrow niche.

DOI：
10.1016/j.bone.2020.115832
发表时间：
2021-03
期刊：
Bone
影响因子：
4.1
作者：
Le PT;Liu H;Alabdulaaly L;Vegting Y;Calle IL;Gori F;Lanske B;Baron R;Rosen CJ
通讯作者：
Rosen CJ

Corrigendum: Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype.