Nitrous oxide anaesthesia and cardiac morbidity in major surgery

氧化亚氮是一种麻醉气体，已经使用了160多年。它一直被认为是一种安全和廉价的药物，但较新的麻醉药和技术的进步提供了可能更安全的替代药物。我们最近的研究发现了一些与一氧化二氮相关的潜在的严重(但罕见的)并发症。这些更有可能发生在患有心脏病的人身上。本研究的目的是调查一氧化二氮在这类人群中的安全性。当考虑到它在澳大利亚(和世界各地)约90%的手术中广泛使用时，结果的微小差异将对医疗保健的提供产生重大影响。要回答这个问题，有必要进行一项设计精良的大型研究。我们计划研究来自世界各地的7000名接受大手术的患者。

Nitrrous oxide is an anaesthtic gas that has been in use for more than 160 years. It has been considered a safe and cheap drug, but newer anaesthetic drugs and improvements in technology provide alternatives that might be safer. Our recent research has found some potentialy serious (but rare) complications associated with nitrous oxide. These are more likely to occur in people with existing heart disease. The purpose of this study is to investigate the safety of nitrous oxide in such people. When considering its widespread use in about 90% of all surgery in Australia (and around the world), small differences in outcome would have major implications for healthcare delivery. A large well-designed study is necessary to answer this question. We plan to study 7,000 patients having major surgery from around the world.