Alzheimer's Disease Processes

老年人在手术后也会发生认知变化，但原因尚不清楚。我们计划研究髋关节手术中全身麻醉和脊髓麻醉同时使用的患者的认知能力。这样我们就可以对脊髓液进行取样分析，找出易患阿尔茨海默病的物质。通过将结果与未接受手术的一组受试者进行比较，我们希望确定麻醉和手术是否会加剧这种倾向。

Cognitive changes after surgery occur in the elderly, yet the cause remains unknown. We plan to study cognition in patients having hip surgery in which general and spinal anaesthesia are used together. This allows us to sample spinal fluid which will be analysed for substances which identify a predisposition to Alzheimer’s disease. By comparing the results to a group of subjects who have not undergone surgery, we hope to identify if anaesthesia and surgery exacerbate this predisposition.