Yale Cooperative Center of Excellence in Hematology

耶鲁大学血液学卓越合作中心

• 批准号: 10249339
• 负责人: PATRICK G GALLAGHER
• 金额: $ 81.39万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10249339
• 关键词: Area; Bioinformatics; Biology; Biomedical Research; Blood Cells; Blood Platelets; Bone Marrow; Cell Communication; Cells; Cellular biology; Collaborations; Core Facility; Country; Development; Disease; Education; Educational process of instructing; Emerging Technologies; Environment; Erythrocyte Transfusion; Faculty; Gene Proteins; Genomics; Goals; Hematological Disease; Hematology; Hematopoiesis; Image; Inherited; Institutes; Institution; Leadership; Learning; Medical Informatics; Medical center; Microscopy; Molecular Biology; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Malignant; Performance; Play; Process; Proteomics; RNA; Regulation; Research; Research Personnel; Research Support; Resources; Role; Scientist; Signal Transduction; Systems Biology; Techniques; Technology; Training; Training Activity; Training and Education; Universities; base; clinical center; clinical investigation; cost effectiveness; gene function; genome analysis; hematopoietic stem cell differentiation; hematopoietic stem cell self-renewal; improved; innovation; interest; medical schools; member; new technology; next generation; novel therapeutic intervention; progenitor; programs; self-renewal; stem cell biology; stem cells; synergism

Abstract The purpose of the Yale Cooperative Center of Excellence in Hematology (YCCEH) is to facilitate and enhance research by investigators engaged in nonmalignant hematology-related research. Our unique focus is the application of emerging technologies to the study of normal and perturbed hematopoiesis. This includes understanding stem cell biology, hematopoiesis, including the processes of self renewal, expansion and differentiation of hematopoietic stem cells, through intermediate progenitor and precursor stages, to mature differentiated and functional blood cells of different lineages. Members of our Research Base are actively engaged in a wide range of topics in the field of hematology, from the stem cell to the bone marrow microenvironment, from understanding mechanisms of hematologic disease to development of novel therapeutic strategies for inherited and acquired disorders, from transfusion of red blood cells and platelets to study of related complications. In parallel, specific technologies utilized across the YCCEH reflect this diversity, with techniques from many fields utilized including cell signaling, genomics, proteomics, RNA biology, molecular biology, advanced imaging and microscopy, to better understand hematologic processes. The resources and environment of the Yale University School of Medicine have been and continue to be particularly well suited to the Center because of the interests and expertise of many of its faculty in the areas of hematology, stem cell biology, genomic analyses and bioinformatics. The availability of a large range of existing core facilities at Yale that directly interface with the YCCEH’s cores, such as the Yale Stem Cell Center, the Yale Center for Genome Analysis, the Yale Center for Clinical Investigation, the Yale Center for Medical Informatics, the Yale Center for High-Performance Computation in Biomedicine, the Yale Systems Biology Institute and the newly established DeLuca Center for Research in Hematology further synergize hematology research across the university. Together, these resources support numerous critical core facilities relevant to hematology investigators. The YCCEH will continue to serve our Research Base (both at Yale and external) by providing training and expertise through the Emerging Technology Research Cores, while providing enhanced opportunities for education and interactions through the Enrichment Core. The Emerging Technology Research Cores will not only enhance research by providing access to cutting edge technologies, but also improve cost-effectiveness of supported research. The long term goal of the YCCEH is to play a key role in the integrated program of hematologic diseases-related research support provided by other NIDDK Cooperative Centers of Excellence in Hematology by providing opportunities to promote increased collaboration within our Research Base and with investigators at other institutions, supporting a broad and deep hematologic diseases research base.

抽象的 耶鲁血液学卓越合作中心 (YCCEH) 的目的是促进和 加强从事非恶性血液学相关研究的研究人员的研究。我们独特的 重点是将新兴技术应用于正常和紊乱造血的研究。这 包括了解干细胞生物学、造血作用，包括自我更新的过程， 通过中间祖细胞和前体细胞进行造血干细胞的扩增和分化 阶段，使不同谱系的分化和功能性血细胞成熟。我们的研究成员 基地积极参与血液学领域的广泛主题，从干细胞到 骨髓微环境，从了解血液疾病的机制到发育 遗传性和获得性疾病的新治疗策略，通过输注红细胞和 血小板以研究相关并发症。与此同时，整个 YCCEH 使用的特定技术 反映了这种多样性，利用了许多领域的技术，包括细胞信号传导、基因组学、 蛋白质组学、RNA 生物学、分子生物学、先进成像和显微镜，以更好地了解 血液学过程。耶鲁大学医学院的资源和环境有 由于其兴趣和专业知识，一直并将继续特别适合该中心 其许多教员从事血液学、干细胞生物学、基因组分析和生物信息学领域。 耶鲁大学现有大量核心设施可与 YCCEH 直接连接 核心，例如耶鲁干细胞中心、耶鲁基因组分析中心、耶鲁大学基因组分析中心 临床研究、耶鲁大学医学信息学中心、耶鲁大学高性能中心 生物医学计算、耶鲁大学系统生物学研究所和新成立的德卢卡中心 血液学研究进一步协同整个大学的血液学研究。在一起，这些 资源支持与血液学研究人员相关的众多关键核心设施。 YCCEH将 通过提供培训和专业知识，继续为我们的研究基地（耶鲁大学和外部的）服务 通过新兴技术研究核心，同时提供更多的教育机会 以及通过强化核心的互动。新兴技术研究核心不仅 通过提供尖端技术来加强研究，同时提高成本效益 的支持研究。 YCCEH 的长期目标是在综合项目中发挥关键作用 其他 NIDDK 合作中心提供的血液病相关研究支持 通过提供促进加强内部合作的机会，在血液学领域取得卓越成就 研究基地并与其他机构的研究人员合作，支持广泛而深入的血液学研究 疾病研究基地。