Yale Cooperative Center of Excellence in Hematology

耶鲁大学血液学卓越合作中心

• 批准号: 10454355
• 负责人: PATRICK G GALLAGHER
• 金额: $ 81.39万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454355
• 关键词: Area; Bioinformatics; Biology; Biomedical Research; Blood Cells; Blood Platelets; Bone Marrow; Cell Communication; Cells; Cellular biology; Collaborations; Core Facility; Country; Development; Disease; Education; Educational process of instructing; Emerging Technologies; Environment; Erythrocyte Transfusion; Faculty; Gene Proteins; Genomics; Goals; Hematological Disease; Hematology; Hematopoiesis; Image; Inherited; Institutes; Institution; Leadership; Learning; Medical Informatics; Medical center; Microscopy; Molecular Biology; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Malignant; Performance; Play; Process; Proteomics; RNA; Regulation; Research; Research Personnel; Research Support; Resources; Role; Scientist; Signal Transduction; Systems Biology; Techniques; Technology; Training; Training Activity; Training and Education; Universities; base; clinical center; clinical investigation; cost effectiveness; gene function; genome analysis; hematopoietic stem cell differentiation; hematopoietic stem cell self-renewal; improved; innovation; interest; medical schools; member; new technology; next generation; novel therapeutic intervention; progenitor; programs; self-renewal; stem cell biology; stem cells; synergism

Abstract The purpose of the Yale Cooperative Center of Excellence in Hematology (YCCEH) is to facilitate and enhance research by investigators engaged in nonmalignant hematology-related research. Our unique focus is the application of emerging technologies to the study of normal and perturbed hematopoiesis. This includes understanding stem cell biology, hematopoiesis, including the processes of self renewal, expansion and differentiation of hematopoietic stem cells, through intermediate progenitor and precursor stages, to mature differentiated and functional blood cells of different lineages. Members of our Research Base are actively engaged in a wide range of topics in the field of hematology, from the stem cell to the bone marrow microenvironment, from understanding mechanisms of hematologic disease to development of novel therapeutic strategies for inherited and acquired disorders, from transfusion of red blood cells and platelets to study of related complications. In parallel, specific technologies utilized across the YCCEH reflect this diversity, with techniques from many fields utilized including cell signaling, genomics, proteomics, RNA biology, molecular biology, advanced imaging and microscopy, to better understand hematologic processes. The resources and environment of the Yale University School of Medicine have been and continue to be particularly well suited to the Center because of the interests and expertise of many of its faculty in the areas of hematology, stem cell biology, genomic analyses and bioinformatics. The availability of a large range of existing core facilities at Yale that directly interface with the YCCEH’s cores, such as the Yale Stem Cell Center, the Yale Center for Genome Analysis, the Yale Center for Clinical Investigation, the Yale Center for Medical Informatics, the Yale Center for High-Performance Computation in Biomedicine, the Yale Systems Biology Institute and the newly established DeLuca Center for Research in Hematology further synergize hematology research across the university. Together, these resources support numerous critical core facilities relevant to hematology investigators. The YCCEH will continue to serve our Research Base (both at Yale and external) by providing training and expertise through the Emerging Technology Research Cores, while providing enhanced opportunities for education and interactions through the Enrichment Core. The Emerging Technology Research Cores will not only enhance research by providing access to cutting edge technologies, but also improve cost-effectiveness of supported research. The long term goal of the YCCEH is to play a key role in the integrated program of hematologic diseases-related research support provided by other NIDDK Cooperative Centers of Excellence in Hematology by providing opportunities to promote increased collaboration within our Research Base and with investigators at other institutions, supporting a broad and deep hematologic diseases research base.

摘要