High Frame Rate 3-D Super Resolution Ultrasound Microvascular Imaging
高帧率 3D 超分辨率超声微血管成像
基本信息
- 批准号:10249991
- 负责人:
- 金额:$ 66.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-10 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAcousticsAddressAnatomyAngiographyAtherosclerosisBlood VesselsBrainBreastBuffersCancer DetectionCancer ModelClinicClinicalClinical ResearchCollaborationsComputer softwareContrast MediaDataDetectionDevelopmentDiagnosticDimensionsEngineeringExhibitsFDA approvedFPS-FES OncogeneFingerprintFrequenciesHourHumanImageImaging TechniquesImaging technologyIndustrializationLesionMalignant - descriptorMalignant NeoplasmsMethodsMicroscopyMorphologyMotionMotivationNatureNorth CarolinaOncologyPaperPerformanceProstatePublic HealthPublishingRattusResearch PersonnelResolutionRodentRodent ModelSafetyScientistSeminalSensitivity and SpecificitySliceSpecificitySystemTechniquesTechnologyTestingThree-Dimensional ImageThree-Dimensional ImagingThyroid GlandTimeTissuesTransducersTranslatingUltrasonographyUniversitiesWorkangiogenesisbasecancer imagingclinical applicationclinically relevantclinically translatablecomputerized data processingcontrast enhancedcontrast imagingcostdata acquisitiondata exchangedata streamsdensitydesigndesign and constructionhuman diseasehuman modelimage processingimaging approachimaging modalityimprovedin vivoinnovationnew growthnew technologynext generationnovelnovel imaging techniquenovel strategiesoptical imagingportabilitypreclinical studyrapid growthresponsesarcomastandard of caretargeted biomarkertumortumor growthvasa vasorumvectorwound healing
项目摘要
ABSTRACT
Recently, the revolutionary technology of super localization microscopy in the optical imaging domain
has been translated into the medical ultrasound domain. By localizing the centers of scattering contrast agents,
a similar ultrasound localization microscopy technique, also referred to as contrast enhanced super-resolution
(CESR) imaging, has been demonstrated with ultrasound. This novel technique enables imaging of microvessels
at resolutions as small as ten micrometers, over an order of magnitude smaller than the ultrasound diffraction
limit, and at depths much greater than traditionally limited by frequency. In order to achieve advances in all three
of these seeming paradoxical dimensions - super-resolution contrast imaging requires that thousands of frames
of data to be analyzed, making this technique much slower than standard ultrasound imaging. The result is that
super-resolution imaging would be difficult if not impossible to translate to the clinic in its current form with current
clinical hardware, especially if 3-D imaging is desired (which it is for microvascular morphological analysis), as
a single 3-D image volume would take tens of minutes to acquire.
However, there is a solution to this, which our group proposes to achieve in this project. Recent advances
in ultrasound hardware have enabled ultra-high frame rate processing. Our academic and clinical teams at UNC
Chapel Hill are partnering with Verasonics, Inc, a world leading industrial partner in next-generation ultrasound
systems, to develop and translate the first high-frame rate 3-D super resolution imaging modality to the clinic.
We will do this by first designing and constructing a 1024 channel ultra-high frame rate ultrasound system,
designed to operate with a 32x32 matrix transducer. Ultra-fast processors, large RAM buffers, GPUs, and high-
bandwidth data transfer hardware will be utilized to handle the massive data acquisition and processing. New
software and implementation approaches designed at UNC, including our innovative adaptive multi-focus
beamforming approach, will further increase sensitivity and resolution at clinically relevant depths, and enable
full 3-D volume acquisitions at volume frame rates over 5000 FPS, suitable for fast 3-D super-resolution imaging
in humans. Our approach will be validated in phantoms, rodent models of human disease, and in two different
clinical applications where ultrasound specificity is limited, breast, and thyroid.
Our motivation is to develop super-resolution imaging as a novel new approach for imaging angiogenesis
– one of the hallmarks of cancer, as a new biomarker target for both diagnostics and assessment of response to
therapy. The ability to differentiate lesions based on microvascular fingerprint, rather than tumor anatomy, would
be a paradigm shift in ultrasound diagnostics, and will improve the specificity of ultrasound to malignancy, and
advance clinically needed in breast, prostate, thyroid, and other oncological applications. However, the
advancement of the proposed technology will undoubtedly open doors to other clinical applications as well, such
as wound healing and vasa vasorum imaging in atherosclerosis.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paul A Dayton其他文献
Therapeutic ultrasound as a potential male contraceptive: power, frequency and temperature required to deplete rat testes of meiotic cells and epididymides of sperm determined using a commercially available system
- DOI:
10.1186/1477-7827-10-7 - 发表时间:
2012-01-01 - 期刊:
- 影响因子:4.700
- 作者:
James K Tsuruta;Paul A Dayton;Caterina M Gallippi;Michael G O'Rand;Michael A Streicker;Ryan C Gessner;Thomas S Gregory;Erick JR Silva;Katherine G Hamil;Glenda J Moser;David C Sokal - 通讯作者:
David C Sokal
Paul A Dayton的其他文献
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{{ truncateString('Paul A Dayton', 18)}}的其他基金
Parametric optimization of ultrasound-mediated immuno-modulation for pancreatic cancer therapy
超声介导的胰腺癌免疫调节的参数优化
- 批准号:
9979314 - 财政年份:2020
- 资助金额:
$ 66.71万 - 项目类别:
Parametric optimization of ultrasound-mediated immuno-modulation for pancreatic cancer therapy
超声介导的胰腺癌免疫调节的参数优化
- 批准号:
10375345 - 财政年份:2020
- 资助金额:
$ 66.71万 - 项目类别:
Parametric optimization of ultrasound-mediated immuno-modulation for pancreatic cancer therapy
超声介导的胰腺癌免疫调节的参数优化
- 批准号:
10092130 - 财政年份:2020
- 资助金额:
$ 66.71万 - 项目类别:
Treating Tumoral Hypoxia via Ultrasound-Guided Oxygen Release for Improving Radiation Therapy
通过超声引导释氧治疗肿瘤缺氧以改善放射治疗
- 批准号:
9978579 - 财政年份:2018
- 资助金额:
$ 66.71万 - 项目类别:
Treating Tumoral Hypoxia via Ultrasound-Guided Oxygen Release for Improving Radiation Therapy
通过超声引导释氧治疗肿瘤缺氧以改善放射治疗
- 批准号:
10632112 - 财政年份:2018
- 资助金额:
$ 66.71万 - 项目类别:
Treating Tumoral Hypoxia via Ultrasound-Guided Oxygen Release for Improving Radiation Therapy
通过超声引导释氧治疗肿瘤缺氧以改善放射治疗
- 批准号:
10402933 - 财政年份:2018
- 资助金额:
$ 66.71万 - 项目类别:
Treating Tumoral Hypoxia via Ultrasound-Guided Oxygen Release for Improving Radiation Therapy
通过超声引导释氧治疗肿瘤缺氧以改善放射治疗
- 批准号:
10163814 - 财政年份:2018
- 资助金额:
$ 66.71万 - 项目类别:
Acoustic Angiography Using Dual-Frequency and Ultrawideband CMUT Arrays
使用双频和超宽带 CMUT 阵列的声学血管造影
- 批准号:
9899252 - 财政年份:2018
- 资助金额:
$ 66.71万 - 项目类别:
High Frame Rate 3-D Super Resolution Ultrasound Microvascular Imaging
高帧率 3D 超分辨率超声微血管成像
- 批准号:
10478978 - 财政年份:2017
- 资助金额:
$ 66.71万 - 项目类别:
High Frame Rate 3-D Super Resolution Ultrasound Microvascular Imaging
高帧率 3D 超分辨率超声微血管成像
- 批准号:
9393119 - 财政年份:2017
- 资助金额:
$ 66.71万 - 项目类别:
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