High Frame Rate 3-D Super Resolution Ultrasound Microvascular Imaging

高帧率 3D 超分辨率超声微血管成像

基本信息

  • 批准号:
    10249991
  • 负责人:
  • 金额:
    $ 66.71万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-08-10 至 2023-07-31
  • 项目状态:
    已结题

项目摘要

ABSTRACT Recently, the revolutionary technology of super localization microscopy in the optical imaging domain has been translated into the medical ultrasound domain. By localizing the centers of scattering contrast agents, a similar ultrasound localization microscopy technique, also referred to as contrast enhanced super-resolution (CESR) imaging, has been demonstrated with ultrasound. This novel technique enables imaging of microvessels at resolutions as small as ten micrometers, over an order of magnitude smaller than the ultrasound diffraction limit, and at depths much greater than traditionally limited by frequency. In order to achieve advances in all three of these seeming paradoxical dimensions - super-resolution contrast imaging requires that thousands of frames of data to be analyzed, making this technique much slower than standard ultrasound imaging. The result is that super-resolution imaging would be difficult if not impossible to translate to the clinic in its current form with current clinical hardware, especially if 3-D imaging is desired (which it is for microvascular morphological analysis), as a single 3-D image volume would take tens of minutes to acquire. However, there is a solution to this, which our group proposes to achieve in this project. Recent advances in ultrasound hardware have enabled ultra-high frame rate processing. Our academic and clinical teams at UNC Chapel Hill are partnering with Verasonics, Inc, a world leading industrial partner in next-generation ultrasound systems, to develop and translate the first high-frame rate 3-D super resolution imaging modality to the clinic. We will do this by first designing and constructing a 1024 channel ultra-high frame rate ultrasound system, designed to operate with a 32x32 matrix transducer. Ultra-fast processors, large RAM buffers, GPUs, and high- bandwidth data transfer hardware will be utilized to handle the massive data acquisition and processing. New software and implementation approaches designed at UNC, including our innovative adaptive multi-focus beamforming approach, will further increase sensitivity and resolution at clinically relevant depths, and enable full 3-D volume acquisitions at volume frame rates over 5000 FPS, suitable for fast 3-D super-resolution imaging in humans. Our approach will be validated in phantoms, rodent models of human disease, and in two different clinical applications where ultrasound specificity is limited, breast, and thyroid. Our motivation is to develop super-resolution imaging as a novel new approach for imaging angiogenesis – one of the hallmarks of cancer, as a new biomarker target for both diagnostics and assessment of response to therapy. The ability to differentiate lesions based on microvascular fingerprint, rather than tumor anatomy, would be a paradigm shift in ultrasound diagnostics, and will improve the specificity of ultrasound to malignancy, and advance clinically needed in breast, prostate, thyroid, and other oncological applications. However, the advancement of the proposed technology will undoubtedly open doors to other clinical applications as well, such as wound healing and vasa vasorum imaging in atherosclerosis.
摘要 近年来,光学成像领域的革命性技术--超局域化显微技术 已经被翻译到医学超声领域。通过定位散射造影剂的中心, 类似的超声定位显微镜技术,也称为对比度增强超分辨率 (CESR)成像,已经用超声证实。这项新技术能够对微血管进行成像 分辨率小至10微米,比超声衍射小一个数量级, 限制,并在深度远大于传统的频率限制。为了在这三个方面都取得进展, 这些看似矛盾的尺寸-超分辨率对比成像需要数千帧, 这使得该技术比标准超声成像慢得多。结果是 超分辨率成像如果不是不可能的话,也很难以其当前的形式转化到临床上, 临床硬件,特别是如果需要3D成像(用于微血管形态分析), 单个3-D图像体积将花费数十分钟来获取。 然而,有一个解决方案,我们的小组建议在这个项目中实现。最新进展 在超声硬件中已经实现了超高帧速率处理。我们的学术和临床团队, 查佩尔山正在与Verasonics公司合作,Verasonics公司是下一代超声领域的世界领先工业合作伙伴 系统,开发和翻译的第一个高帧率的三维超分辨率成像模式的临床。 为此,我们将首先设计和构建一个1024通道超高帧率超声系统, 设计用于32 x32矩阵传感器。超快处理器、大容量RAM缓冲区、GPU和高性能 将利用带宽数据传输硬件来处理大量数据采集和处理。新 软件和实施方法,包括我们创新的自适应多焦点 波束成形方法,将进一步提高在临床相关深度的灵敏度和分辨率, 以超过5000 FPS的体积帧速率进行全三维体积采集,适用于快速三维超分辨率成像 在人类身上。我们的方法将在幻影,人类疾病的啮齿动物模型,以及两个不同的实验中得到验证。 超声特异性有限的临床应用,乳腺和甲状腺。 我们的动机是发展超分辨率成像作为一种新的新的方法成像血管生成 - 癌症的标志之一,作为诊断和评估对 疗法基于微血管指纹而不是肿瘤解剖结构来区分病变的能力, 是超声诊断的范式转变,并将提高超声对恶性肿瘤的特异性, 乳腺癌、前列腺癌、甲状腺癌和其他肿瘤应用的临床需要。但 所提出的技术的进步无疑也将为其他临床应用打开大门, 如动脉粥样硬化中的伤口愈合和血管造影。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Paul A Dayton其他文献

Therapeutic ultrasound as a potential male contraceptive: power, frequency and temperature required to deplete rat testes of meiotic cells and epididymides of sperm determined using a commercially available system
  • DOI:
    10.1186/1477-7827-10-7
  • 发表时间:
    2012-01-01
  • 期刊:
  • 影响因子:
    4.700
  • 作者:
    James K Tsuruta;Paul A Dayton;Caterina M Gallippi;Michael G O'Rand;Michael A Streicker;Ryan C Gessner;Thomas S Gregory;Erick JR Silva;Katherine G Hamil;Glenda J Moser;David C Sokal
  • 通讯作者:
    David C Sokal

Paul A Dayton的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Paul A Dayton', 18)}}的其他基金

Parametric optimization of ultrasound-mediated immuno-modulation for pancreatic cancer therapy
超声介导的胰腺癌免疫调节的参数优化
  • 批准号:
    9979314
  • 财政年份:
    2020
  • 资助金额:
    $ 66.71万
  • 项目类别:
Parametric optimization of ultrasound-mediated immuno-modulation for pancreatic cancer therapy
超声介导的胰腺癌免疫调节的参数优化
  • 批准号:
    10375345
  • 财政年份:
    2020
  • 资助金额:
    $ 66.71万
  • 项目类别:
Parametric optimization of ultrasound-mediated immuno-modulation for pancreatic cancer therapy
超声介导的胰腺癌免疫调节的参数优化
  • 批准号:
    10092130
  • 财政年份:
    2020
  • 资助金额:
    $ 66.71万
  • 项目类别:
Treating Tumoral Hypoxia via Ultrasound-Guided Oxygen Release for Improving Radiation Therapy
通过超声引导释氧治疗肿瘤缺氧以改善放射治疗
  • 批准号:
    9978579
  • 财政年份:
    2018
  • 资助金额:
    $ 66.71万
  • 项目类别:
Treating Tumoral Hypoxia via Ultrasound-Guided Oxygen Release for Improving Radiation Therapy
通过超声引导释氧治疗肿瘤缺氧以改善放射治疗
  • 批准号:
    10632112
  • 财政年份:
    2018
  • 资助金额:
    $ 66.71万
  • 项目类别:
Treating Tumoral Hypoxia via Ultrasound-Guided Oxygen Release for Improving Radiation Therapy
通过超声引导释氧治疗肿瘤缺氧以改善放射治疗
  • 批准号:
    10402933
  • 财政年份:
    2018
  • 资助金额:
    $ 66.71万
  • 项目类别:
Treating Tumoral Hypoxia via Ultrasound-Guided Oxygen Release for Improving Radiation Therapy
通过超声引导释氧治疗肿瘤缺氧以改善放射治疗
  • 批准号:
    10163814
  • 财政年份:
    2018
  • 资助金额:
    $ 66.71万
  • 项目类别:
Acoustic Angiography Using Dual-Frequency and Ultrawideband CMUT Arrays
使用双频和超宽带 CMUT 阵列的声学血管造影
  • 批准号:
    9899252
  • 财政年份:
    2018
  • 资助金额:
    $ 66.71万
  • 项目类别:
High Frame Rate 3-D Super Resolution Ultrasound Microvascular Imaging
高帧率 3D 超分辨率超声微血管成像
  • 批准号:
    10478978
  • 财政年份:
    2017
  • 资助金额:
    $ 66.71万
  • 项目类别:
High Frame Rate 3-D Super Resolution Ultrasound Microvascular Imaging
高帧率 3D 超分辨率超声微血管成像
  • 批准号:
    9393119
  • 财政年份:
    2017
  • 资助金额:
    $ 66.71万
  • 项目类别:

相似海外基金

Nonlinear Acoustics for the conditioning monitoring of Aerospace structures (NACMAS)
用于航空航天结构调节监测的非线性声学 (NACMAS)
  • 批准号:
    10078324
  • 财政年份:
    2023
  • 资助金额:
    $ 66.71万
  • 项目类别:
    BEIS-Funded Programmes
ORCC: Marine predator and prey response to climate change: Synthesis of Acoustics, Physiology, Prey, and Habitat In a Rapidly changing Environment (SAPPHIRE)
ORCC:海洋捕食者和猎物对气候变化的反应:快速变化环境中声学、生理学、猎物和栖息地的综合(蓝宝石)
  • 批准号:
    2308300
  • 财政年份:
    2023
  • 资助金额:
    $ 66.71万
  • 项目类别:
    Continuing Grant
University of Salford (The) and KP Acoustics Group Limited KTP 22_23 R1
索尔福德大学 (The) 和 KP Acoustics Group Limited KTP 22_23 R1
  • 批准号:
    10033989
  • 财政年份:
    2023
  • 资助金额:
    $ 66.71万
  • 项目类别:
    Knowledge Transfer Partnership
User-controllable and Physics-informed Neural Acoustics Fields for Multichannel Audio Rendering and Analysis in Mixed Reality Application
用于混合现实应用中多通道音频渲染和分析的用户可控且基于物理的神经声学场
  • 批准号:
    23K16913
  • 财政年份:
    2023
  • 资助金额:
    $ 66.71万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapy
结合辐射声学和超声成像,用于放射治疗的实时指导
  • 批准号:
    10582051
  • 财政年份:
    2023
  • 资助金额:
    $ 66.71万
  • 项目类别:
Comprehensive assessment of speech physiology and acoustics in Parkinson's disease progression
帕金森病进展中言语生理学和声学的综合评估
  • 批准号:
    10602958
  • 财政年份:
    2023
  • 资助金额:
    $ 66.71万
  • 项目类别:
The acoustics of climate change - long-term observations in the arctic oceans
气候变化的声学——北冰洋的长期观测
  • 批准号:
    2889921
  • 财政年份:
    2023
  • 资助金额:
    $ 66.71万
  • 项目类别:
    Studentship
Collaborative Research: Estimating Articulatory Constriction Place and Timing from Speech Acoustics
合作研究:从语音声学估计发音收缩位置和时间
  • 批准号:
    2343847
  • 财政年份:
    2023
  • 资助金额:
    $ 66.71万
  • 项目类别:
    Standard Grant
Collaborative Research: Estimating Articulatory Constriction Place and Timing from Speech Acoustics
合作研究:从语音声学估计发音收缩位置和时间
  • 批准号:
    2141275
  • 财政年份:
    2022
  • 资助金额:
    $ 66.71万
  • 项目类别:
    Standard Grant
Flow Physics and Vortex-Induced Acoustics in Bio-Inspired Collective Locomotion
仿生集体运动中的流动物理学和涡激声学
  • 批准号:
    DGECR-2022-00019
  • 财政年份:
    2022
  • 资助金额:
    $ 66.71万
  • 项目类别:
    Discovery Launch Supplement
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了