Development and Functional Assessment of Cardiovascular Tissue Engineering Therapy (CVTE) T32 Training Grant

心血管组织工程疗法 (CVTE) T32 培训资助的开发和功能评估

• 批准号: 10256806
• 负责人: Jack M Rogers
• 金额: $ 17.41万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10256806
• 关键词: Cardiovascular system; Development; Grant; Tissue Engineering; Training

ABSTRACT Tissue engineering has unrealized potential to treat cardiovascular disease, for example, by reversing contractile dysfunction following myocardial infarction. However, the field faces many challenges. Methods to enhance rates of cell engraftment and to direct differentiation of cells into functioning tissue are urgently needed. A major problem is that therapy recipients face potentially lethal electrophysiological instability. We propose to develop a new interdisciplinary predoctoral training program in cardiovascular tissue engineering (CVTE). Particular emphasis will be placed on in vivo evaluation of CVTE therapy using innovative technology. Participating faculty will be drawn from university units including Biomedical Engineering, Cardiovascular Disease, Molecular Genetics, and Pathology. The program will take advantage of recent institutional investments in CVTE (part of a realignment of Biomedical Engineering as a joint department between the Schools of Engineering and Medicine) as well as existing research strengths in cardiovascular physiology (in particular cardiac electrophysiology), stem cell biology, and other CVTE subfields. Students in the program will be exposed to the molecular and cellular biological foundations of CVTE; specific tissue engineering subjects such as scaffold design and CVTE fabrication/vascularization; and broader biomedical engineering subjects such as optics, imaging technology, and biomechanics that are critical for fabricating and evaluating engineered constructs. Topics relevant to translation such as clinical trials and the regulatory environment will also be covered. Trainees will be recruited from the Biomedical Engineering Doctoral program and UAB’s Graduate Biomedical Sciences Program. Many students will have a background in biomedical engineering while others will have undergraduate degrees in other engineering disciplines, the physical sciences, or life science. Students will typically be supported by an institutional fellowship in their first year of graduate training and will be supported by the proposed training program in their second and third years. The mentor pool will include a “core” group of funded investigators and an additional “content” group. Both groups will include investigators from a spectrum of engineering and life science departments. Each student will have a primary mentor from the core group with additional mentors selected from a range of complimentary disciplines to ensure a broad training perspective. We expect that this arrangement will foster interdisciplinary training as well as new collaborations among mentors. While there will be a common set of courses for all trainees, including a new course in CVTE, each trainee’s mentorship team will customize coursework according to their research interests and preparation. A journal club specific to this program will be organized. Students will be expected to participate in numerous relevant seminar series available on campus. Our ultimate goal is to produce professionals able to accelerate the safe clinical adoption of CVTE technology. We expect that graduates will go on to careers in academics, industry and government.

摘要 组织工程在治疗心血管疾病方面具有尚未实现的潜力，例如，通过逆转 心肌梗死后的收缩功能障碍。然而，该领域面临许多挑战。方法 迫切需要提高细胞移植的速率并将细胞直接分化为功能组织。 一个主要的问题是，治疗接受者面临着潜在的致命的电生理不稳定性。我们建议 开发一个新的跨学科的心血管组织工程（CVTE）博士前培训计划。 将特别强调使用创新技术进行CVTE治疗的体内评价。 参与的教师将来自大学单位，包括生物医学工程，心血管 疾病、分子遗传学和病理学。该计划将利用最近的机构投资 在CVTE（生物医学工程的重新调整的一部分，作为学校之间的联合部门， 工程和医学）以及心血管生理学（特别是 心脏电生理学）、干细胞生物学和其他CVTE子领域。 该计划的学生将接触CVTE的分子和细胞生物学基础;具体 组织工程学科，如支架设计和CVTE制造/血管化;以及更广泛的 生物医学工程学科，如光学，成像技术和生物力学，是至关重要的 制造和评估工程构建体。与翻译相关的主题，如临床试验和 监管环境也将受到影响。培训生将从生物医学工程博士 项目和UAB的研究生生物医学科学项目。许多学生将有背景， 生物医学工程，而其他人将在其他工程学科的本科学位， 物理科学或生命科学。学生通常会在他们的第一个机构奖学金的支持 一年的研究生培训，并将在其第二年和第三年的拟议培训计划的支持。 导师库将包括一个由受资助的调查人员组成的“核心”小组和一个额外的“内容”小组。两组 将包括来自工程和生命科学部门的调查人员。每个学生将有一个 从核心组中选出主要导师，从一系列互补学科中选出其他导师 以确保广阔的培训前景。我们期望这一安排将促进跨学科培训， 以及导师之间的新合作。虽然将为所有学员提供一套共同的课程，包括 CVTE的新课程，每个学员的导师团队将根据他们的研究定制课程 兴趣和准备。将组织一个专门针对该计划的期刊俱乐部。学生将有望 参加校园内众多相关的系列研讨会。 我们的最终目标是培养能够加速CVTE安全临床应用的专业人员 技术.我们希望毕业生将继续在学术，工业和政府的职业生涯。