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NCI X-ray free electron laser (XFEL) initiative

NCI X-ray free electron laser (XFEL) initiative
NCI X 射线自由电子激光 (XFEL) 倡议
批准号：
10262391
负责人：
Yun Xing m wang
金额：
$70.14万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10262391
关键词：
ArrestinsAtomic Force MicroscopyAwardBiologicalBreast Cancer PreventionCCRCOVID-19 pandemicCellsCharacteristicsClinicCryoelectron MicroscopyCrystallizationCrystallographyDataDevicesDrug TargetingEventFoundationsFutureG-Protein-Coupled ReceptorsGenesGranulovirusHumanImageImmunotherapyKineticsLasersLigand BindingLigandsLightLymphocyteManuscriptsMembrane ProteinsMethodsMinor GrooveMolecularMonitorMusOrganismPaperPeer ReviewPhase TransitionPhysiologic pulseProcessProteinsProtocols documentationPublicationsRNARNA ConformationReactionReportingResearch PersonnelResearch Project GrantsResolutionRhodopsinRoentgen RaysScienceSourceStructureSynchrotronsTemperatureThe SunTimeUniversitiesVirionVisualVisualizationWorkaqueouscrystallinitydesignflexibilitymalignant breast neoplasmmolecular imagingmovienanocrystalnovel strategiespreventprogrammed cell death protein 1serial imagingsingle moleculex-ray free-electron laser

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中文摘要
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英文摘要
We have been mostly focusing on the analysis of the XFEL data that was collected in the past and made several fundamental discoveries. one of the most important results is the discovery of the mechanism of lattice phase transition triggered by ligand binding in a crystalline state. This mechanism is fundamental to the visualization of molecular movies. The results are being written in a manuscript. The XFEL beam at LCLS was shut down for an upgrade for 2019 and was expected to be operational in the middle of 2020 but was not available due to the COVID-19 pandemic.
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Search for the Structural Basis of Biomacromolecular Function and Activity
  • 批准号：
    8763088
  • 项目类别：
  • 资助金额：
    $147.83万
  • 财政年份：
    --
  • 负责人：
    Yun Xing m wang
  • 依托单位：
    DIVISION OF BASIC SCIENCES - NCI
Search for the Structural Basis of Biomacromolecular Function and Activity
  • 批准号：
    8552680
  • 项目类别：
  • 资助金额：
    $127.85万
  • 财政年份：
    --
  • 负责人：
    Yun Xing m wang
  • 依托单位：
    DIVISION OF BASIC SCIENCES - NCI
Search for the Structural Basis of Biomacromolecular Function and Activity
  • 批准号：
    8348990
  • 项目类别：
  • 资助金额：
    $104.24万
  • 财政年份：
    --
  • 负责人：
    Yun Xing m wang
  • 依托单位：
    DIVISION OF BASIC SCIENCES - NCI
Search for the Structural Basis of Biomacromolecular Function and Activity
  • 批准号：
    10702344
  • 项目类别：
  • 资助金额：
    $256.09万
  • 财政年份：
    --
  • 负责人：
    Yun Xing m wang
  • 依托单位：
    DIVISION OF BASIC SCIENCES - NCI
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