The 2020 ESPINA study follow-up Exam: Fungicides, Insecticides, Inflammation and Child Development

2020年ESPINA研究后续考试:杀菌剂、杀虫剂、炎症和儿童发育

基本信息

项目摘要

The sales of agricultural insecticides have steadily risen in the last 20 years and the use of fungicides have skyrocketed in the last decade. Unfortunately, direct assessments of children's developmental toxicity in relation to commonly used fungicides such as Azoles or Quinone Outside Inhibitors (QoI) are unavailable because methods for their quantification in bio-specimens have only recently been developed. In experimental studies, exposures QoI fungicides, resulted in epigenetic changes related to neuro-inflammation, and higher levels of free-radicals. Azoles, another heavily used fungicide class, have also been linked with liver inflammation and toxicity in-vitro. Azole fungicides share the same structure as azole antifungals used in clinical practice, which are associated with elevations of liver enzymes in up to 20% of patients. Cholinesterase inhibitor insecticide exposures have been associated with short- and long-lasting neurobehavioral/cognitive delays in children associated. Whether continuing exposures to organophosphates or other insecticides such as neonicotinoids or pyrethroids can affect cognition in adolescence is unclear. We propose to conduct a follow-up investigation of adolescent participants (ages 16-21 y, n=535) of the Secondary Pesticide Exposure among Children and Adolescents (ESPINA) study in 2020. This NIH-funded study has examined participants in Pedro Moncayo County, Ecuador since 2008. Pedro Moncayo has one of the highest concentrations of flower plantations in the Americas. The production of flowers involves a disproportionately high use of fungicides. We plan to assess the ongoing and long-term associations of pesticide exposures with neurocognition, and inflammatory markers (systemic, neuro and liver). To our knowledge, this will be the first epidemiologic study of children/adolescents to evaluate health outcomes in relation to fungicide and neonicotinoid exposures. This prospective study capitalizes on existing blood measurements of insecticides in 2016 and acetylcholinesterase in 2008 and 2016. The specific aims are to test the following hypotheses: Urinary metabolites of insecticides in 2016 and 2020 (organophosphates, neonicotinoids, pyrethroids) and fungicides (Azoles, QoI) in 2016 are associated with: 1) higher subclinical markers of systemic and neuro inflammation (CRP, TNF, IL-6, sICAM-1, sVCAM-1, MCP-1, sCD14, sCD163); 2) Pesticides, particularly azole fungicides are associated with subclinical increases in liver inflammation markers: transaminases (AST and ALT) and cytokeratin 18. We will test concurrent and prospective associations with all inflammation markers in 2016-2018; 3) lower neur0-cognitive performance in adolescence. We will test longitudinal associations of fungicides and insecticides with neurocognitive performance, and will contrast such findings across pesticides to evaluate neurotoxic potencies. 4) As an exploratory aim: we will assess mediating or modifying effects of inflammation on pesticide-induced impaired neurobehavioral performance.
在过去的20年里,农业杀虫剂的销售和杀菌剂的使用稳步上升

项目成果

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Jose Ricardo Suarez其他文献

Jose Ricardo Suarez的其他文献

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{{ truncateString('Jose Ricardo Suarez', 18)}}的其他基金

The 2020 ESPINA study follow-up Exam: Fungicides, Insecticides, Inflammation and Child Development
2020年ESPINA研究后续考试:杀菌剂、杀虫剂、炎症和儿童发育
  • 批准号:
    10457234
  • 财政年份:
    2020
  • 资助金额:
    $ 52万
  • 项目类别:
The 2020 ESPINA study follow-up Exam: Fungicides, Insecticides, Inflammation and Child Development
2020年ESPINA研究后续考试:杀菌剂、杀虫剂、炎症和儿童发育
  • 批准号:
    9716417
  • 财政年份:
    2020
  • 资助金额:
    $ 52万
  • 项目类别:
The 2020 ESPINA study follow-up Exam: Fungicides, Insecticides, Inflammation and Child Development
2020年ESPINA研究后续考试:杀菌剂、杀虫剂、炎症和儿童发育
  • 批准号:
    10659041
  • 财政年份:
    2020
  • 资助金额:
    $ 52万
  • 项目类别:
The ESPINA Study Follow-up Examination in 2016: Environmental Pollutants and Child/Adolescent Development
2016年ESPINA研究跟踪检查:环境污染物与儿童/青少年发展
  • 批准号:
    9905409
  • 财政年份:
    2016
  • 资助金额:
    $ 52万
  • 项目类别:
The ESPINA Study Follow-up Examination in 2016: Environmental Pollutants and Child/Adolescent Development
2016年ESPINA研究跟踪检查:环境污染物与儿童/青少年发展
  • 批准号:
    9242028
  • 财政年份:
    2016
  • 资助金额:
    $ 52万
  • 项目类别:
The ESPINA Study Follow-up Examination in 2016: Environmental Pollutants and Child/Adolescent Development
2016年ESPINA研究跟踪检查:环境污染物与儿童/青少年发展
  • 批准号:
    9053238
  • 财政年份:
    2016
  • 资助金额:
    $ 52万
  • 项目类别:
Pesticides and Mental Health among Adolescents in Ecuadorian Agricultural Communities
厄瓜多尔农业社区青少年的农药与心理健康
  • 批准号:
    8992538
  • 财政年份:
    2015
  • 资助金额:
    $ 52万
  • 项目类别:
Pesticides and Mental Health among Adolescents in Ecuadorian Agricultural Communities
厄瓜多尔农业社区青少年的农药与心理健康
  • 批准号:
    9132795
  • 财政年份:
    2015
  • 资助金额:
    $ 52万
  • 项目类别:
Effects of Secondary Occupational Pesticide Exposure on Childhood Growth
次要职业农药接触对儿童生长的影响
  • 批准号:
    7393501
  • 财政年份:
    2007
  • 资助金额:
    $ 52万
  • 项目类别:

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