The 2020 ESPINA study follow-up Exam: Fungicides, Insecticides, Inflammation and Child Development
2020年ESPINA研究后续考试:杀菌剂、杀虫剂、炎症和儿童发育
基本信息
- 批准号:10265315
- 负责人:
- 金额:$ 52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-18 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AcetylcholinesteraseAdolescenceAdolescentAffectAgeAgricultureAmericasAntifungal AgentsAzolesBiological MarkersBloodCCL2 geneChildChild DevelopmentChild HealthCholinesterase InhibitorsCognitionCognitiveCountyCytochrome P450Cytokeratin 18Data CollectionDevelopmentDiseaseDrug Metabolic DetoxicationEcuadorEnvironmental HealthEnzymesEpigenetic ProcessExposure toFatty LiverFlowersFollow-Up StudiesFoodFree RadicalsFundingFutureGenderHairHealthHepatotoxicityHumanImpairmentIn VitroIndustrial fungicideInflammationInsecticidesInterleukin-6InvestigationLinkLiverMeasurementMeasuresMediatingMental HealthMethodsMicrotubulesNational Institute of Environmental Health SciencesNerve DegenerationNeurocognitionNeurocognitiveNeurocognitive DeficitNeuronsOrganophosphatesOutcomeParticipantPatientsPerformancePesticidesPharmaceutical PreparationsPhysiologicalPlasmaPopulationPrevention programProcessProductionProspective StudiesQuinonesRecurrenceResearchRisk AssessmentSafetySalesSalivaSamplingSerumSpecimenStructureTNF geneTechnologyTestingTimeToxic effectTransaminasesUnited States National Institutes of HealthUrineVascular EndotheliumWorkagricultural communityagricultural pesticidebiobankclinical practicecognitive performancecohortdevelopmental toxicitydisorder preventionepidemiology studyexperimental studyexposure pathwayfollow-upfruits and vegetablesindividuals with autism spectrum disorderinflammatory markerinhibitor/antagonistliver inflammationmonocyteneurobehaviorneurobehavioralneuroinflammationneurotoxicnovelpesticide exposureprenatal exposureprospectiveprospective testpyrethroidstudy populationurinaryyoung adult
项目摘要
The sales of agricultural insecticides have steadily risen in the last 20 years and the use of fungicides
have skyrocketed in the last decade. Unfortunately, direct assessments of children's developmental toxicity in
relation to commonly used fungicides such as Azoles or Quinone Outside Inhibitors (QoI) are unavailable
because methods for their quantification in bio-specimens have only recently been developed. In experimental
studies, exposures QoI fungicides, resulted in epigenetic changes related to neuro-inflammation, and higher
levels of free-radicals. Azoles, another heavily used fungicide class, have also been linked with liver
inflammation and toxicity in-vitro. Azole fungicides share the same structure as azole antifungals used in
clinical practice, which are associated with elevations of liver enzymes in up to 20% of patients.
Cholinesterase inhibitor insecticide exposures have been associated with short- and long-lasting
neurobehavioral/cognitive delays in children associated. Whether continuing exposures to organophosphates
or other insecticides such as neonicotinoids or pyrethroids can affect cognition in adolescence is unclear.
We propose to conduct a follow-up investigation of adolescent participants (ages 16-21 y, n=535) of the
Secondary Pesticide Exposure among Children and Adolescents (ESPINA) study in 2020. This NIH-funded
study has examined participants in Pedro Moncayo County, Ecuador since 2008. Pedro Moncayo has one of
the highest concentrations of flower plantations in the Americas. The production of flowers involves a
disproportionately high use of fungicides. We plan to assess the ongoing and long-term associations of
pesticide exposures with neurocognition, and inflammatory markers (systemic, neuro and liver). To our
knowledge, this will be the first epidemiologic study of children/adolescents to evaluate health outcomes in
relation to fungicide and neonicotinoid exposures. This prospective study capitalizes on existing blood
measurements of insecticides in 2016 and acetylcholinesterase in 2008 and 2016.
The specific aims are to test the following hypotheses: Urinary metabolites of insecticides in 2016
and 2020 (organophosphates, neonicotinoids, pyrethroids) and fungicides (Azoles, QoI) in 2016 are associated
with: 1) higher subclinical markers of systemic and neuro inflammation (CRP, TNF, IL-6, sICAM-1, sVCAM-1,
MCP-1, sCD14, sCD163); 2) Pesticides, particularly azole fungicides are associated with subclinical increases in
liver inflammation markers: transaminases (AST and ALT) and cytokeratin 18. We will test concurrent and
prospective associations with all inflammation markers in 2016-2018; 3) lower neur0-cognitive performance
in adolescence. We will test longitudinal associations of fungicides and insecticides with neurocognitive
performance, and will contrast such findings across pesticides to evaluate neurotoxic potencies. 4) As an
exploratory aim: we will assess mediating or modifying effects of inflammation on pesticide-induced impaired
neurobehavioral performance.
在过去的20年里,农业杀虫剂的销售和杀菌剂的使用稳步上升
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jose Ricardo Suarez其他文献
Jose Ricardo Suarez的其他文献
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{{ truncateString('Jose Ricardo Suarez', 18)}}的其他基金
The 2020 ESPINA study follow-up Exam: Fungicides, Insecticides, Inflammation and Child Development
2020年ESPINA研究后续考试:杀菌剂、杀虫剂、炎症和儿童发育
- 批准号:
10457234 - 财政年份:2020
- 资助金额:
$ 52万 - 项目类别:
The 2020 ESPINA study follow-up Exam: Fungicides, Insecticides, Inflammation and Child Development
2020年ESPINA研究后续考试:杀菌剂、杀虫剂、炎症和儿童发育
- 批准号:
9716417 - 财政年份:2020
- 资助金额:
$ 52万 - 项目类别:
The 2020 ESPINA study follow-up Exam: Fungicides, Insecticides, Inflammation and Child Development
2020年ESPINA研究后续考试:杀菌剂、杀虫剂、炎症和儿童发育
- 批准号:
10659041 - 财政年份:2020
- 资助金额:
$ 52万 - 项目类别:
The ESPINA Study Follow-up Examination in 2016: Environmental Pollutants and Child/Adolescent Development
2016年ESPINA研究跟踪检查:环境污染物与儿童/青少年发展
- 批准号:
9905409 - 财政年份:2016
- 资助金额:
$ 52万 - 项目类别:
The ESPINA Study Follow-up Examination in 2016: Environmental Pollutants and Child/Adolescent Development
2016年ESPINA研究跟踪检查:环境污染物与儿童/青少年发展
- 批准号:
9242028 - 财政年份:2016
- 资助金额:
$ 52万 - 项目类别:
The ESPINA Study Follow-up Examination in 2016: Environmental Pollutants and Child/Adolescent Development
2016年ESPINA研究跟踪检查:环境污染物与儿童/青少年发展
- 批准号:
9053238 - 财政年份:2016
- 资助金额:
$ 52万 - 项目类别:
Pesticides and Mental Health among Adolescents in Ecuadorian Agricultural Communities
厄瓜多尔农业社区青少年的农药与心理健康
- 批准号:
8992538 - 财政年份:2015
- 资助金额:
$ 52万 - 项目类别:
Pesticides and Mental Health among Adolescents in Ecuadorian Agricultural Communities
厄瓜多尔农业社区青少年的农药与心理健康
- 批准号:
9132795 - 财政年份:2015
- 资助金额:
$ 52万 - 项目类别:
Effects of Secondary Occupational Pesticide Exposure on Childhood Growth
次要职业农药接触对儿童生长的影响
- 批准号:
7393501 - 财政年份:2007
- 资助金额:
$ 52万 - 项目类别:
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