The Adolescent Master Protocol (AMP) Up Series Project

青少年大师协议 (AMP) Up 系列项目

• 批准号: 10264953
• 负责人: Katherine K. Tassiopoulos
• 金额: $ 25.48万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-18 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264953
• 关键词: 15 year old; 18 year old; Address; Adherence; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Age; Aging; Alcohol consumption; Anti-Retroviral Agents; Behavior; Body Composition; Bone Density; Brain; Cardiac; Cardiopulmonary; Cardiovascular Diseases; Caring; Centers for Disease Control and Prevention (U.S.); Cervical; Child; Clinic; Clinic Visits; Clinical; Cohort Studies; Data; Data Collection; Disease; Disease remission; Emotional; Enrollment; Ensure; Epigenetic Process; Family dynamics; Generations; Genetic; Goals; Growth; HIV; HIV Infections; HIV antiretroviral; Health; Health behavior outcomes; Healthcare; Hearing; Human Papillomavirus; Immunologic Factors; Individual; Infant; Inflammatory; Influentials; Intervention; Kidney; Language; Lesion; Long-Term Effects; Longterm Follow-up; Lung; Medical; Mental Health; Metabolic; Nervous System Physiology; Neurocognitive; Neurologic; Nutritional; Oral; Oral health; Organ; Outcome; Participant; Pediatric HIV/AIDS Cohort Study; Perinatal; Persons; Pharmaceutical Preparations; Postpartum Period; Protocols documentation; Psyche structure; Publications; Research; Research Design; Role; Self Management; Series; Sex Behavior; Sexual Maturation; Sexually Transmitted Diseases; Social Functioning; Social support; Structure; Tobacco use; Toxic effect; Viral; Viremia; Visit; Woman; antiretroviral therapy; behavioral health; bone; cardiovascular disorder risk; cardiovascular risk factor; clinical care; cohort; comparison group; design; early childhood; emotional functioning; flexibility; follow-up; health care service utilization; health management; high risk; innovation; neurodevelopment; pediatric human immunodeficiency virus; perinatal HIV; physical conditioning; pubertal timing; recreational drug use; reproductive; reproductive outcome; scale up; social; social structure; sociodemographics; substance use; treatment adherence; treatment response; vaccine efficacy; virology; young adult

PROJECT SUMMARY The Centers for Disease Control and Prevention estimates that in 2016, there were 11,915 persons with perinatally-acquired HIV (PHIV) in the U.S., including 10,101 adolescents and young adults. Globally, 1.7 million children under the age of 15 are living with HIV and with effective antiretroviral medications (ARVs) are expected to survive into adolescence, young adulthood and beyond. The Adolescent Master Protocol (AMP) was designed to evaluate long-term effects of HIV infection and ARVs on multiple domains. AMP enrolled 451 children with PHIV between ages 7-16 years and 227 children living with perinatal HIV exposure but uninfected (PHEU) from 2007-09. The AMP Up and AMP Up Lite studies (AMP Up Series) were developed to allow for continued follow-up of young adults with PHIV (YAPHIV) beyond 18 years of age, including AMP participants, to assess physical and mental health as they transition to adulthood. These innovative studies share similar objectives and are designed to facilitate long- term follow-up with annual online and medical chart abstracted data collection. AMP has been highly productive with numerous influential publications. AMP Up has yielded important information – including the role of social support and ability to self-manage health care on a successful transition to adult clinical care, and the high risk of postpartum viremia and early HPV-associated cervical lesions. Yet the long-term effects of HIV and ARV on health in young adulthood are still unfolding. The comprehensive data collected since early childhood on a substantial subset of AMP Up participants previously in AMP provides the invaluable opportunity to assess how early HIV and ARV, mental health, neurocognitive function, and family dynamics impact adult outcomes. The specific aims of the AMP Up Series are to: 1. Define the impact of PHIV infection, ARVs, and individual, social and structural factors on: the transition to adulthood and adult care; brain structure and neurological functioning; academic, vocational, emotional and social functioning; mental health; medication and health care adherence; sexual behaviors; and substance use. 2. Identify infectious and non-infectious complications of HIV and their associations with ARVs and HIV. 3. Investigate genetic, epigenetic, virologic, inflammatory, and immunologic factors which impact the course of HIV infection, its complications, the response to treatment, and potential for HIV remission/cure.

项目摘要 疾病控制和预防中心估计，2016年，有11，915人患有 围产期获得性艾滋病毒（PHIV）在美国，包括10，101名青少年和年轻人。全球1.7 200万15岁以下儿童感染艾滋病毒， 预计将存活到青春期，青年期和以后。 青少年主协议（AMP）旨在评估艾滋病毒感染的长期影响， 多个领域的抗逆转录病毒药物。AMP招募了451名7-16岁的PHIV儿童和227名儿童 2007年至2009年期间，患有围产期艾滋病毒暴露但未感染（PHEU）。AMP UP和AMP UP Lite 开展了一项研究（AMP Up系列），以便继续随访年轻的PHIV感染者 （YAPHIV）18岁以上，包括AMP参与者，以评估他们的身心健康， 过渡到成年。这些创新的研究有着相似的目标，旨在促进长期的- 定期随访，每年在线收集医学图表摘要数据。 AMP的生产力很高，出版了许多有影响力的出版物。AMP Up已经产生了重要的 信息-包括社会支持的作用和自我管理保健的能力， 过渡到成人临床护理，产后病毒血症和早期HPV相关宫颈癌的高风险， 病变然而，艾滋病毒和抗逆转录病毒药物对青年人健康的长期影响仍在显现。的 从儿童早期开始收集的大量AMP Up参与者的综合数据， AMP的研究提供了宝贵的机会，可以评估早期艾滋病毒和抗逆转录病毒药物、心理健康、神经认知 功能和家庭动态影响成人的结果。AMP Up系列的具体目标是： 1.定义艾滋病毒感染、抗逆转录病毒药物以及个人、社会和结构因素对以下方面的影响： 成人和成人护理;大脑结构和神经功能;学术，职业，情感和 社会功能;心理健康;药物和卫生保健依从性;性行为;和物质使用。 2.确定艾滋病毒的感染性和非感染性并发症及其与抗逆转录病毒药物和艾滋病毒的关系。 3.研究影响疾病进程的遗传、表观遗传、病毒学、炎症和免疫学因素， 艾滋病毒感染，其并发症，对治疗的反应，以及艾滋病毒缓解/治愈的潜力。