Viscoelastic and volumetric contributions to age-related cognitive decline

粘弹性和体积对与年龄相关的认知能力下降的贡献

• 批准号: 10266862
• 负责人: Hillary Schwarb
• 金额: $ 7.93万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10266862
• 关键词: Age; Age-associated memory impairment; Aging; Alzheimer' s Disease; Assessment tool; Atrophic; Behavior; Behavioral; Biological; Brain; Brain region; Characteristics; Cognition; Cognitive; Corpus striatum structure; Data; Data Set; Development; Diagnosis; Disease; Eye Movements; Future; Health; Hippocampus (Brain); Human; Imaging Techniques; Impaired cognition; Impairment; Individual; Investigation; Learning; Liquid substance; Literature; Longevity; Magnetic Resonance Elastography; Magnetic Resonance Imaging; Measures; Mediating; Memory; Memory impairment; Methods; Neurologic; Outcome; Parkinson Disease; Participant; Patient-Focused Outcomes; Performance; Population; Positioning Attribute; Prevention; Process; Property; Proxy; Research; Resolution; Risk; Structure; Techniques; Tissues; Treatment outcome; Ursidae Family; Validation; Work; age related neurodegeneration; aging brain; behavior test; behavioral response; brain health; brain tissue; brain volume; cognitive ability; cognitive neuroscience; cognitive performance; cognitive process; cognitive testing; cost; effective intervention; gray matter; healthy aging; in vivo; learning ability; mechanical properties; neuroimaging; new technology; novel; novel strategies; pathological aging; relating to nervous system; relational memory; sequence learning; success; tool; viscoelasticity; visual tracking; young adult

PROJECT SUMMARY/ABSTRACT It is well understood that typical aging is accompanied by characteristic declines in fluid cognitive abilities as well as declines in the structural integrity of the brain. Structural integrity has typically been inferred from measures of brain volume. Volume, however, is a gross measure that cannot account for smaller-scale changes that may be contributing to diminished cognitive outcomes. Magnetic resonance elastography (MRE) is an emerging tool for acquiring noninvasive measures of the mechanical properties of biological tissue. As such, MRE provides a measure of the microstructural health of the tissue. The proposed work seeks (1) to assess the utility of MRE as a complementary tool to volumetric analysis in the study of human learning and memory and also (2) to establish MRE as a critically sensitive method for mapping degeneration in the aging brain, particularly when volumetric outcomes are equivocal. Volumetric, MRE, and cognitive data will be collected from 80 participants between the ages of 45 and 85. The cognitive assessment will measure both relational memory abilities (dependent on hippocampal function) and implicit sequence learning abilities (dependent on striatal function). Volumetric and MRE analyses will focus on the hippocampus and striatum specifically. These data will be used to examine the relationship between relational memory performance and both hippocampal volume and MRE-derived hippocampal viscoelasticity, as well as implicit sequence learning and both striatal volume and viscoelasticity, to explore the unique contribution of each to behavior. It is expected that, compared to volumetric measures alone, viscoelasticity measures will provide additional explanatory power when investigating the impact of tissue integrity on cognitive outcomes. This work will establish MRE as a useful tool for the study of cognitive neuroscience of aging and highlight the importance of choosing appropriate neuroimaging tools when assessing structural integrity. The resulting data will have important implications for tracking structural changes that impact cognitive abilities in typical aging as well as the diagnosis and tracking of treatment outcomes for patients with hippocampal (e.g., Alzheimer’s disease) and striatal (e.g., Parkinson’s disease) impairments.

项目总结/摘要 众所周知，典型的衰老伴随着流体认知能力的特征性下降， 以及大脑结构完整性的下降。结构完整性通常是从 测量脑容量。然而，成交量是一个总体指标，无法解释较小规模的情况 这些变化可能会导致认知功能下降。磁共振弹性成像（MRE） 是一种新兴的工具，用于获取生物组织的机械性能的非侵入性测量。作为 因此，MRE提供了组织的微观结构健康的量度。拟议的工作旨在（1） 评估地雷风险教育作为人体学习研究中体积分析的补充工具的效用， 记忆和（2）建立MRE作为一个非常敏感的方法映射退化的老化 大脑，特别是当体积结果不明确时。体积、MRE和认知数据将被 收集了80名年龄在45岁到85岁之间的参与者。认知评估将衡量 关系记忆能力（依赖于海马功能）和内隐序列学习能力 （取决于纹状体功能）。体积和MRE分析将集中在海马和纹状体 具体来说这些数据将用于检查关系内存性能与 海马体积和MRE衍生的海马粘弹性，以及内隐序列学习 以及纹状体体积和粘弹性，以探索各自对行为的独特贡献。是 预计，与单独的体积测量相比，粘弹性测量将提供额外的 在研究组织完整性对认知结果的影响时，这项工作将 建立MRE作为研究衰老认知神经科学的有用工具，并强调以下方面的重要性： 在评估结构完整性时选择适当的神经成像工具。产生的数据将具有 跟踪影响典型衰老中认知能力的结构变化以及 对患有海马的患者的治疗结果的诊断和跟踪（例如，阿尔茨海默病）和 纹状体的（例如，帕金森氏病）损伤。