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Comprehensive Research Experiences to Advance Training and Education (CREATE) for Future Cancer Researchers

全面的研究经验可促进未来癌症研究人员的培训和教育 (CREATE)

基本信息

批准号：
10269302
负责人：
Priyamvada Rai
金额：
$ 30.23万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10269302
关键词：
Academic Training Academic skills Address Affect Area Bioinformatics Biological Markers Biology Biomedical Research Biotechnology Cancer Burden Cancer Control Cancer Research Project Catchment Area Cause of Death Clinical Oncology Clinical Trials Design Communities Community Health Community Outreach Complement Comprehensive Cancer Center Country Coupled Custom Data Analyses Data Set Databases Development Diagnosis Disease Education Educational Curriculum Educational workshop Ensure Environment Epigenetic Process Exposure to Faculty Feedback Fellowship Program Florida Foundations Future Genome Goals Immunotherapy Incidence Incubators Individual Infrastructure Instruction Knowledge Literature Location Malignant Neoplasms Mentors Methodology Mining Modernization Monitor Oncologist Oncology Outcome Participant Patients Physicians Population Positioning Attribute Public Health Reading Research Research Institute Research Personnel Research Project Grants Resources Students Supervision Therapeutic Time Training Training and Education Treatment outcome Tumor Biology United States Universities Validation Writing anticancer research base burden of illness cancer health disparity career career development commercialization drug development drug discovery efficacy evaluation epigenome experience faculty mentor faculty research field trip hands on instruction health disparity innovation insight interest medical schools next generation novel outreach peer peer coaching peer networks personalized medicine phase I trial programs recruit screening skills sociodemographics socioeconomic disparity summer program symposium technological innovation therapeutic target tool trial design undergraduate research undergraduate research experience undergraduate student

项目摘要

Project Summary Despite major advances in diagnosis and treatment, there remains a need for sustained research and therapeutic innovation to reduce cancer burden. Besides experimental biology, the landscape of oncology research now encompasses computational patient dataset mining for new biomarkers and therapeutic targets, genome and epigenome analysis-based personalized medicine, and application of how sociodemographic and socioeconomic disparities affect cancer incidence and outcomes. The next generation of researchers must receive early exposure to this comprehensive, integrated view of modern oncology, so they can make informed and innovative decisions regarding specialization or cross-specialization options throughout their future education. The proposed CREATE program for future cancer researchers aims to accomplish this goal by integrating a 10-week mentored undergraduate cancer research program with foundational modules on computational drug discovery and development and cancer health disparities-based research. This program will build and expand on the UMMSOM/Sylvester Comprehensive Cancer Center (SCCC)-sponsored pre-existing summer program infrastructure to facilitate research projects tailored to individual scholar interest alongside comprehensive academic and career development support. Complementarily, through a hands-on mini-project, CREATE scholars will receive hands-on instruction in bioinformatics and computational approaches required to develop a robust therapeutic pipeline. SCCC serves a diverse catchment area that will be leveraged to provide CREATE scholars with unique opportunities for understanding the impact of cancer disparities at the community level on disease incidence and treatment outcomes. Currently, only undergraduates actively engaged in computational projects or health disparities research benefit from their exposure to these essential research areas. Our proposed curriculum will ensure all our scholars develop a working understanding of these areas in addition to accomplishing substantive bench research with world-class faculty mentors. CREATE scholars will also experience clinical oncology components including physician shadowing and basic instruction in Phase I trial design. They will receive sustained programmatic and peer mentoring support as they navigate the next steps in their academic training. An important aspect of enhancing the cancer research workforce is outreach and engagement with student populations who do not have research opportunities due to their location or circumstances. SCCC is only the second NCI-designated center in the entire state of Florida. As such, our institutional summer program receives more qualified applicants than we can support, demonstrating a clear interest from undergraduates across the country in our cancer research resources and environment. We are, thus, in a unique position to offer the innovative CREATE program to help produce the next generation of cancer researchers with the comprehensive training and knowledge to succeed in oncology-based careers.

项目总结