Tuberculosis & HIV Co-Infection Training Program in Kenya

摘要 结核病(TB)是艾滋病毒感染者(PLHIV)的主要死亡原因。尽管 100多年前结核分枝杆菌(Mtb)的发现和有效药物的可获得性 60多年来，控制结核病仍然存在着巨大的障碍，包括缺乏高效的 疫苗，长期药物治疗方案，预防感染，杀死巨噬细胞内的休眠细菌。 为了解决这些问题，需要开发新的研究和公共卫生战略，并将其结合起来 在结核病高发国家加强培训和当地能力建设。肯尼亚是30个结核病高发区之一 造成负担的国家加起来占全球结核病病例的80%以上。内罗毕大学(UON)， 肯尼亚医学研究所(KEMRI)和华盛顿大学(UW)提出了一项新的 结核病-艾滋病毒培训计划(TBHTP)以满足这些需求。TBHTP包括在以下方面的密切合作 肯尼亚与卫生部国家结核病、麻风和肺病项目(MoH NTLP)合作，以及 肯尼亚儿科研究联盟(KEPRECON)-附属于肯尼亚的研究组织 儿科协会(KPA)我们计划的主要目标是协作开发培训 在培训和研究能力建设方面满足当地需求的机会。这一伙伴关系建立在35- 威斯康星大学、KEMRI和UON在艾滋病毒研究方面合作和培训的一年历史。虽然这件事 尽管伙伴关系取得了很大成功，但结核病并不是以前努力的高度优先事项或重点目标。至 建设KEMRI和内罗毕大学(UON)进行结核病和结核病-艾滋病毒联合感染的能力 调研后，我们建议实行学位制的长期培训轨道，实行中期不培训 学位赛道和短期训练赛道。在5年内，我们将培训5 UW英里每小时，5 UON 流行病学奖学金，以及在KEMRI、UON或卫生部工作的5名UON博士生。我们还将进行培训 10名对结核病研究有兴趣和潜力的中期非学位科学家将参加威斯康星大学的 学习流行病学和生物统计学的课程，或在实验室工作一到三个月，然后回到 并参与了一个有指导的研究项目。最后，我们将举办短期研讨会，并提供 建立大量训练有素的研究人员的在线课程，这些研究人员将为 结核病方面的研究。这些培训机会加在一起，将提高当地的能力，并培训下一个 将发现抗击结核病的新研究和公共卫生战略的一代领导人 肯尼亚的流行病。

Abstract Tuberculosis (TB) is the leading cause of death in people living with HIV infection (PLHIV). Despite the discovery of Mycobacterium tuberculosis (Mtb) over 100 years ago and the availability of effective drugs for over 60 years, there remain formidable hurdles for controlling TB including the lack of a highly efficacious vaccine, long drug treatment regimens, prevention of infection, and killing dormant bacilli within macrophages. To address these problems, novel research and public health strategies need to be developed and coupled with enhanced training and local capacity building in high TB endemic countries. Kenya is one of 30 TB high burden countries which together constitute over 80% of global TB cases. The University of Nairobi (UoN), the Kenya Medical Research Institute (KEMRI) and the University of Washington (UW) propose a new TB-HIV Training Program (TBHTP) to address these needs. The TBHTP includes close partnerships in Kenya with the Ministry of Health National Tuberculosis Leprosy and Lung Disease Program (MoH NTLP), and the Kenya Pediatric Research Consortium (KEPRECON) – the research organization affiliated with the Kenya Pediatric Association (KPA). The primary goal of our program is to collaboratively develop training opportunities to address local needs in training and research capacity building. This partnership builds on a 35- year history of collaboration and training in HIV research between UW, KEMRI, and UoN. Although this partnership has been highly successful, TB has not been a high priority or focused goal of previous efforts. To build the capacity of KEMRI and the University of Nairobi (UoN) to conduct TB and TB-HIV co-infection research, we propose to implement a long-term training degree-earning track, a medium-term training non- degree track, and a short-term training track. During the 5-year period, we will train 5 UW MPH, 5 UoN Fellowship in Epidemiology, and 5 UoN PhD students working at KEMRI, UoN, or the MoH. We will also train 10 medium term non-degree scientists who have interest and potential in TB research will attend UW and take coursework in epidemiology and biostatistics or work in a laboratory for one to three months before returning to Kenya and engaging in a mentored research project. Finally, we will conduct short term workshops and provide on-line courses to build a critical mass of trained researchers who will create a supportive environment for research in TB. Together, these training opportunities will enhance local capacity and train the next generation of leaders who will discover novel research and public health strategies to combat the TB epidemic in Kenya.