Exploration of Race, Obesity, and Metabolomics on the Development of Iron Deficiency in Young Women

种族、肥胖和代谢组学对年轻女性缺铁发展的探索

• 批准号: 10242050
• 负责人: Jacquelyn M Powers
• 金额: $ 12.62万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-20 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10242050
• 关键词: Address; Adolescence; Affect; African American; Age; Anemia; Biological Assay; Biological Markers; Blood Volume; Body mass index; Caucasians; Clinical Data; Controlled Study; Cross-Sectional Studies; Data; Development; Diagnosis; Dietary Iron; Early identification; Early treatment; Ethnic group; Evaluation; Fatigue; Female Adolescents; Ferritin; Future; Goals; Growth; Health; Hemorrhage; Homeostasis; Incidence; Individual; Inflammation; Intake; Intervention Studies; Iron; Laboratory Markers; Longitudinal Studies; Longitudinal cohort; Matched Group; Menarche; Methodology; Methods; Minority Groups; National Heart, Lung, and Blood Institute; Neurocognitive; Obesity; Oral; Outcome; Patient-Focused Outcomes; Population; Positioning Attribute; Predictive Factor; Pregnancy Histories; Prevalence; Prognostic Marker; Prospective cohort; Questionnaires; Race; Randomized Controlled Trials; Research; Risk; Risk Factors; Sampling; Serum; Severities; Specimen; Study Subject; TFRC gene; Testing; Time; Time Study; United States; United States Dept. of Health and Human Services; Work; base; biracial; clinical risk; cognitive function; cohort; design; epidemiology study; evidence base; exercise capacity; experience; follow-up; girls; high risk; indexing; iron deficiency; large datasets; metabolomics; muscle form; novel; novel marker; obese person; obesity risk; predictive marker; prognostic; prognostic value; racial minority; risk prediction; screening; screening guidelines; tool; young woman

PROJECT SUMMARY Iron deficiency (ID) affects an estimated 9 to 16% of adolescent girls in the United States and disproportionately affects African American girls. ID, with and without anemia, is associated with decreased cognitive function, diminished exercise capacity, and increased fatigue. Unrecognized ID can progress to complications of severe anemia. Despite readily available therapy with oral iron, there are no universal screening recommendations or evidence-based risk prediction tools to identify those girls at highest risk for its development. Early identification of at-risk girls would allow for well-designed, long-term, controlled studies that evaluate the effects of screening for and early treatment of ID on important health outcomes. The research aims of this project are to: 1) determine the prevalence of, timing of, and risk factors for ID in a large, biracial cohort of adolescent girls; and 2) identify novel biomarkers of ID through global serum profiling by metabolomics. To achieve this goal, we will utilize existing clinical data and specimens from the National Heart Lung and Blood Institute (NHLBI) Growth and Health Study (NGHS), a longitudinal study of obesity risk factors in African American and Caucasian girls followed annually from age 9-10 years to 18-19 years. We will assay serum samples drawn at serial time points (Years 1, 3, 5, 7, and 10) from NGHS subjects for whom at least 4 samples are available (n=693) over the 10-year period. We will determine ID status using both traditional and novel iron parameters, including serum ferritin and soluble transferrin receptor 1 (sTfR1) to determine the prevalence and timing of ID and assess clinical risk factors that are predictive of the ID development. We will perform unbiased profiling of metabolites in 40 samples to characterize metabolites that are altered in ID versus non-ID subjects and compare candidate metabolites to standard iron parameters to find those that may be used as predictive markers of ID in minority and/or obese populations. Our research team’s experience in epidemiologic and interventional studies in the field of ID, methodologic experience with the use of large datasets, and track record of performing large-scale bioassays, well-positions us to achieve our objectives. The results from this study will inform both the development of a risk prediction tool and evidenced-based screening recommendations for ID in adolescent girls. Identifying metabolites associated with ID will substantiate the prognostic value of candidate metabolites as biomarkers of ID compared to standard iron parameters. Overall, this work is required to provide the preliminary data that justifies a future R01 application to fully assess the benefits of ID screening, treatment initiation, and follow-up. The results will directly address the U.S. Department of Health and Human Services’ Healthy People objective of reducing ID in adolescent girls and young women.

项目摘要 铁缺乏症（ID）影响美国估计有9％至16％的青少年女孩，并且不成比例 影响非裔美国女孩。 id，有或没有贫血，与改善的认知功能有关， 运动能力降低并增加了疲劳。无法识别的ID可以发展为严重的并发症 贫血。尽管可以使用口服铁的疗法可用，但没有普遍的筛查建议或 基于证据的风险预测工具可以识别那些面临其发展风险最高的女孩。早期识别 处于危险的女孩将允许精心设计，长期对照研究，以评估筛查的影响 对于重要的健康状况，对ID的早期治疗。 该项目的研究目的是：1）确定ID的患病率，时间和风险因素 大，混血儿队的青春期女孩； 2）通过全球血清分析确定ID的新型生物标志物 代谢组学。为了实现这一目标，我们将利用国家心脏的现有临床数据和标本 肺和血液研究所（NHLBI）生长与健康研究（NGHS），肥胖风险因素的纵向研究 在非洲裔美国人和高加索女孩中，每年从9-10岁到18-19岁。我们将分析 NGHS受试者的串行时间点（1、3、5、7和10年）绘制的血清样品至少为4 在10年期间可用样品（n = 693）。我们将使用传统和 新的铁参数，包括血清铁蛋白和固体转铁蛋白受体1（STFR1），以确定 ID和评估临床风险因素的患病率和时机可以预测ID的发展。我们将 在40个样本中对代谢物进行无偏分析，以表征ID与ID相对于ID的代谢产物 非ID受试者并将候选代谢物与标准铁参数进行比较以找到可以使用的参数 作为少数群体和/或肥胖人群中ID的预测标记。 我们的研究团队在ID领域的流行病学和介入研究方面的经验，方法论 使用大型数据集的经验以及表演大规模生物测定，位置良好的记录 我们实现我们的目标。这项研究的结果将为风险预测工具的开发提供信息 以及对青春期女孩的ID的基于证据的筛查建议。识别相关的代谢产物 与标准相比 铁参数。总体而言，这项工作需要提供初步数据，以证明未来R01的合理性 应用以充分评估ID筛查，治疗计划和随访的好处。结果将 直接探讨美国卫生与公共服务部的健康人的目标 减少青春期女孩和年轻女性的ID。