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Shedding light on brain circuits mediating navigation of the odor plume in a natural environment

揭示自然环境中调节气味羽流的大脑回路

基本信息

批准号：
10241846
负责人：
Emily Gibson
金额：
$ 8.95万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2022-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10241846
关键词：
Achievement Algorithms Animals Anterior nares Area BRAIN initiative Bachelor&apos s Degree Back Bayesian Analysis Behavior Biomedical Engineering Brain Brain imaging Brain region Cells Code Colorado Complex Computer Analysis Coupled Custom Data Development Devices Doctor of Philosophy Eating Environment Environmental Engineering technology Faculty Fiber Funding Graduate Education Grant Hippocampus (Brain)Image Intercalated Cell Laboratories Lasers Light Location London Maps Measurement Measures Mechanics Mediating Methods Microscope Monitor Motion Mus Neurons Neurosciences Odors Organism Partner in relationship Persons Photons Population Problem Solving Psychology Research Site Solid Source Students System Techniques Testing Three-Dimensional Imaging Training United States National Institutes of Health Universities Weight analytical method analytical tool base college design doctoral student experience graduate student instrument interdisciplinary approach interest member novel optical imaging photoionization portability programs relating to nervous system sensor tool two-photon

项目摘要

Project Summary Navigating within an odor plume is a complex task due to unpredictable changes in odor concentration. The algorithms used by organisms to navigate the odor plume remain mysterious and how the brain solves this complex sensorimotor task key to escaping, mating and eating is unknown (1). The problem is challenging because it requires parallel monitoring of: 1) brain activity in multiple brain regions in the freely moving animal, 2) odor plume dynamics, 3) sniffing and 4) animal motion. While optical imaging is an attractive solution, imaging neural activity in multiple brain regions in the freely moving animal is currently impossible with either commercial or custom miniscopes (2). Members of our Odor Plume Neurophotonics (OPeN) interdisciplinary team developed a novel two photon fiber-coupled microscope for 3D imaging of brain activity in the freely moving mouse under funding from an NIH BRAIN U01 and an NSF NCS:FOUNDATIONS grant (3)(Bright, Gibson, Gopinath and Restrepo) and quantified realistic odor environments in the laboratory to explore algorithms used for odor-guided navigation under funding by an NSF Ideas Lab “Cracking the Olfactory Code” (Crimaldi)(4). Here, we leverage the extensive expertise of the team to crack the circuit basis for odor plume navigation. We will develop a multi-site miniature 3-photon fiber coupled microscope (3P-FCM) to record neuronal activity in four brain sites in two planes of view. In addition, OPeN will develop a portable photoionization (PID) sensor to detect the odorant concentration at the nostril as the animal navigates the odor plume. Finally, OPeN team members will develop a Bayesian analysis method to decode odor plume navigation from neural activity. The OPeN advisory board includes faculty from universities such as Cornell University and the University College of London, and will include two Directors of NSF NeuroNex Hubs. Understanding the circuit basis of odor plume navigation is impossible using current technology. This will be a major accomplishment involving systems neuroscience, neurophotonics and environmental engineering. The instruments and analysis methods developed by OPeN will be an important contribution to understanding brain function in complex environments. OPeN will foster training of graduate students and postdocs cracking the neural basis of odor plume navigation.

项目总结

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Fabrication and characterization of a two-dimensional individually addressable electrowetting microlens array.

二维独立可寻址电润湿微透镜阵列的制造和表征。

DOI：
10.1364/oe.497992
发表时间：
2023
期刊：
Optics express
影响因子：
3.8
作者：
Gilinsky,SamuelD;Zohrabi,Mo;Lim,WeiYang;Supekar,OmkarD;Bright,VictorM;Gopinath,JulietT
通讯作者：
Gopinath,JulietT

Ultra‐Thin Ceramic Substrates for Improved Heat sinking for MicroLEDs

DOI：
10.1002/admt.202300390
发表时间：
2023-08
期刊：
Advanced Materials Technologies
影响因子：
6.8
作者：
Christine K. McGinn;Vikrant Kumar;Megan Noga;Zachary A. Lamport;Ioannis Kymissis
通讯作者：
Christine K. McGinn;Vikrant Kumar;Megan Noga;Zachary A. Lamport;Ioannis Kymissis