Consider the influence of injury type and survival interval on cTBI neuropathology

研究项目3 摘要 越来越多的人担心暴露于创伤性脑损伤(TBI)和增加 各种神经精神和神经认知结果的风险，特别是与参与 联系体育。此外，令人信服的流行病学数据表明，严重的脑外伤是一种重要的环境因素。 痴呆症的危险因素，目前的最佳估计表明，所有痴呆症患者中可能有5%至15%的人患有痴呆症 与TBI相关。无论是历史上还是现在，脑外伤相关的痴呆都被推定为基于 取决于是单发、中度、重度还是重复、轻度的脑外伤。然而，在过去的十年里， 尸检研究揭示了各种损伤个体的复杂和重叠的病理 曝光。关键的是，对脑外伤的范围和分布也缺乏全面的了解。 神经退行性变(趋势)病理所需产生的神经功能障碍，症状谱 与这种病理有关，或与更广泛的神经退行性疾病有关。因此，有一个 迫切需要对整个趋势进行公正、全面和有力的评估 病理与患者相关变量和临床结果的比较。我们将使用全面的 来自慢性脑损伤的大量病例材料档案的数据集(约850个现有的和预计将增加的 约450名新的慢性脑损伤患者)和配对的对照通过这种CONNECT-TBI计划成为可能。检查这些内容 独特的组织资源和相关联的临床数据集提供了无与伦比的机会，将全面的 结合神经病理学观察的结果和评估。我们建议1)考察 损伤变量，以及2)确定神经病理负担和生前之间的关联 慢性颅脑损伤的临床病理表现。

Research Project 3 SUMMARY There is growing concern over the association between exposure to traumatic brain injury (TBI) and increased risk of a variety of neuropsychiatric and neurocognitive outcomes, in particular those linked to participation in contact sports. Moreover, compelling epidemiological data indicates severe TBI as an important environmental risk factor for dementia with best current estimates suggesting that between 5 and 15% of all dementia may be TBI related. Both historically and currently, TBI-associated dementia has been presumptively subdivided based on whether it follows a single, moderate or severe TBI or repetitive, mild TBI. However, over the last decade, autopsy studies have revealed complex and overlapping pathologies in individuals across the spectrum of injury exposure. Critically, there is also an incomplete understanding of the extent and distribution of TBI related neurodegeneration (TReND) pathology required to produce neurological dysfunction, the spectrum of symptoms associated with this pathology, or its relationship with wider neurodegenerative disease. As such, there is a pressing need to perform unbiased, comprehensive and robust evaluations of the complete spectrum of TReND pathologies in comparison with patient associated variables and clinical outcomes. We will use comprehensive datasets of the extensive archive of case material from chronic TBI (~850 existing and the predicted additional ~450 new chronic TBI) and matched controls made possible via this CONNECT-TBI Program. Examining these unique tissue resources and linked clinical datasets offers an unrivalled opportunity to link comprehensive outcomes and assessments with neuropathological observations. We propose to 1) examine the influence of injury variables, and 2) Determine the association between neuropathological burden and antemortem clinicopathologic presentation of chronic TBI.