Consider the influence of injury type and survival interval on cTBI neuropathology

研究项目3 总结 越来越多的人关注创伤性脑损伤（TBI）暴露与脑损伤发生率增加之间的关系。 各种神经精神和神经认知结果的风险，特别是与参与 身体接触的运动此外，令人信服的流行病学数据表明，严重的TBI是一个重要的环境因素， 痴呆症的风险因素，目前最佳估计表明，所有痴呆症中有5 - 15%可能是 TBI相关无论是在历史上还是现在，TBI相关的痴呆症已经被假定细分为基于 是否遵循单一，中度或重度TBI或重复，轻度TBI。然而，在过去的十年里， 尸检研究揭示了各种损伤的个体中复杂和重叠的病理学 exposure.重要的是，对TBI相关的程度和分布也有不完全的了解。 神经变性（TReND）病理需要产生神经功能障碍，症状谱 与这种病理学相关，或其与更广泛的神经退行性疾病的关系。因此，有一个 迫切需要对TReND的完整光谱进行无偏见，全面和可靠的评估 与患者相关变量和临床结局相比，我们将全面 来自慢性TBI的病例材料的广泛档案的数据集（约850个现有和预测的额外病例） 约450例新的慢性TBI）和匹配的对照组通过该CONNECT-TBI计划成为可能。研究这些 独特的组织资源和相关的临床数据集提供了无与伦比的机会， 结果和评估与神经病理学观察。我们建议：1）研究 损伤变量，以及2）确定神经病理学负荷与死前 慢性TBI的临床病理表现。

Research Project 3 SUMMARY There is growing concern over the association between exposure to traumatic brain injury (TBI) and increased risk of a variety of neuropsychiatric and neurocognitive outcomes, in particular those linked to participation in contact sports. Moreover, compelling epidemiological data indicates severe TBI as an important environmental risk factor for dementia with best current estimates suggesting that between 5 and 15% of all dementia may be TBI related. Both historically and currently, TBI-associated dementia has been presumptively subdivided based on whether it follows a single, moderate or severe TBI or repetitive, mild TBI. However, over the last decade, autopsy studies have revealed complex and overlapping pathologies in individuals across the spectrum of injury exposure. Critically, there is also an incomplete understanding of the extent and distribution of TBI related neurodegeneration (TReND) pathology required to produce neurological dysfunction, the spectrum of symptoms associated with this pathology, or its relationship with wider neurodegenerative disease. As such, there is a pressing need to perform unbiased, comprehensive and robust evaluations of the complete spectrum of TReND pathologies in comparison with patient associated variables and clinical outcomes. We will use comprehensive datasets of the extensive archive of case material from chronic TBI (~850 existing and the predicted additional ~450 new chronic TBI) and matched controls made possible via this CONNECT-TBI Program. Examining these unique tissue resources and linked clinical datasets offers an unrivalled opportunity to link comprehensive outcomes and assessments with neuropathological observations. We propose to 1) examine the influence of injury variables, and 2) Determine the association between neuropathological burden and antemortem clinicopathologic presentation of chronic TBI.