Optimizing mHealth for adherence monitoring and intervention

优化移动医疗以进行依从性监测和干预

• 批准号: 10251996
• 负责人: Jessica Elizabeth Haberer
• 金额: $ 18.15万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10251996
• 关键词: AIDS prevention; Adherence; Africa; Anti-Retroviral Agents; Award; Boston; Caring; Consolidated Framework for Implementation Research; Counseling; Data; Development; Dose; Faculty; Feedback; Foundations; Funding; General Hospitals; Goals; Grant; Growth; HIV; HIV antiretroviral; Health Benefit; Health Technology; Individual; Infrastructure; Ingestion; Institution; International; Internist; Intervention; Lead; Manuscripts; Massachusetts; Medicine; Mentors; Mentorship; Methodology; Mid-Career Clinical Scientist Award (K24); Monitor; National Institute of Mental Health; Paper; Pattern; Peer Review; Pharmaceutical Preparations; Postdoctoral Fellow; Principal Investigator; Process; Productivity; Proxy; Publications; Research; Research Personnel; Rewards; Risk; Role; Rural; Structure; Talents; Text Messaging; Time; Training; Tuberculosis; Uganda; United States National Institutes of Health; Viral; Work; Writing; antiretroviral therapy; base; burden of illness; career; clinical care; comorbidity; design; doctoral student; experience; global health; implementation science; implementation strategy; improved; interest; mHealth; medical schools; mid-career faculty; patient oriented research; pill; pre-doctoral; programs; skills; therapy adherence; tool; uptake; viral rebound; viral transmission

Project summary Overview. This application for a K24 mid-career investigator award proposes to support mentoring for junior investigators interested in mHealth to improve adherence monitoring and intervention for HIV and related comorbid conditions. Candidate: Dr. Haberer is a practicing internist, the Director of Research at the Massachusetts General Hospital (MGH) Center for Global Health, and an Associate Professor of Medicine at Harvard Medical School (HMS). She has nearly 10 years of experience studying adherence to antiretroviral therapy for both the treatment and prevention of HIV in developing settings, with a particular focus on mHealth. Dr. Haberer is considered a leader in her field and most specifically in electronic adherence monitors and SMS-based monitoring and intervention. Dr. Haberer is also a dedicated mentor and has supported 21 pre-doctoral students, residents, post-doctoral fellows and junior faculty, both in Boston and abroad. Her mentees have written 18 first author papers (5 additional papers are in process) and received six NIH-funded grants with her guidance. As a testament to her mentoring, she won the prestigious HMS Young Mentor Award in 2014. Mentoring Plan: Dr. Haberer’s mentoring goals are to 1) increase mentoring activities in mHealth-based adherence monitoring and intervention; and 2) establish a structured mentoring program at the MGH Center for Global Health. She can access mentees through MGH, HMS, and other Harvard-affiliated institutions, as well as her research partner institutions in East Africa. Dr. Haberer is currently the principal investigator on two R01 grants through NIMH, as well as a large scale grant through the Bill and Melinda Gates Foundation. She therefore has the capacity for numerous mentees to participate in her on-going studies through analysis of existing data and supplemental projects. Dr. Haberer will also be expanding her research into implementation science, in which she will engage additional mentees. She has been receiving an increasing number of requests for mentorship that would require the support of this award. Research Plan: Dr. Haberer proposes to expand her research program into implementation science for mHealth-based adherence monitoring and intervention. This goal involves both acquiring formal training in implementation science, as well as conducting implementation science research on the use of electronic ART adherence monitoring plus support for routine clinical care in Uganda. She aims to 1) conduct multi-level formative work to design a preliminary implementation strategy; and 2) use an iterative approach to optimize the implementation strategy based on the Consolidated Framework for Research Implementation. This proposed research will help determine ways to move effective mHealth tools from the research context into routine clinical care, as well as advance Dr. Haberer’s career and serve as a platform for mentee involvement.

项目总结 概述。这份申请K24职业生涯中期调查员奖的申请书建议支持初级指导 研究人员对移动健康感兴趣，以改善对艾滋病毒及其相关疾病的依从性、监测和干预 并存的条件。 候选人：哈伯勒博士是一名执业内科医生，也是马萨诸塞州总医院的研究主任 MGH全球健康中心、哈佛医学院医学副教授 (HMS)。她有近10年的研究经验，研究对两种疾病的抗逆转录病毒治疗 发展中环境中艾滋病毒的治疗和预防，特别注重移动保健。哈伯勒医生是 被认为是其所在领域的领导者，尤其是在电子遵从性监视器和基于短信的 监测和干预。哈贝勒博士也是一位敬业的导师，他已经支持了21名博士后 来自波士顿和国外的学生、住院医生、博士后研究员和初级教员。她的导师们 撰写了18篇第一作者论文(5篇其他论文正在进行中)，并与她一起获得了6项NIH资助 指导。作为对她的指导的证明，她在2014年获得了享有盛誉的HMS青年导师奖。 指导计划：Haberer博士的指导目标是：1)增加基于mHealth的指导活动 依从性监测和干预；以及2)在MGH中心建立结构化的指导计划 全球健康。她还可以通过MGH、HMS和其他哈佛附属机构访问学员 作为她在东非的研究伙伴机构。哈贝勒博士目前是两个R01的首席研究员 通过NIMH提供的赠款，以及通过比尔和梅林达·盖茨基金会提供的大规模赠款。她 因此，她有能力通过分析以下内容，让众多学员参与她的持续学习 现有数据和补充项目。哈贝勒博士还将把她的研究扩展到实施 科学，她将参与更多的辅导者。她收到了越来越多的 需要本奖项支持的辅导请求。 研究计划：Haberer博士建议将她的研究计划扩展到实施科学 基于移动健康的依从性监测和干预。这一目标包括在以下两方面获得正式培训 实施科学，以及就电子艺术的使用进行实施科学研究 在乌干达，依从性监测加上对常规临床护理的支持。她的目标是1)进行多层次的 设计初步实施策略的形成性工作；以及2)使用迭代方法进行优化 以研究实施综合框架为基础的实施战略。这 拟议的研究将有助于确定如何将有效的移动健康工具从研究背景转移到 常规临床护理，以及促进Haberer博士的职业生涯，并作为学员参与的平台。

项目成果

Factors Affecting the Implementation of Electronic Antiretroviral Therapy Adherence Monitoring and Associated Interventions for Routine HIV Care in Uganda: Qualitative Study.

• DOI: 10.2196/18038
• 发表时间: 2020-09-10
• 期刊: Journal of medical Internet research
• 影响因子: 7.4
• 作者: Haberer JE;Garrison L;Tumuhairwe JB;Baijuka R;Tindimwebwa E;Tinkamanyire J;Burns BF;Asiimwe S
• 通讯作者: Asiimwe S

The impact of prevention-effective PrEP use on HIV incidence: a mathematical modelling study.

• DOI: 10.1002/jia2.26034
• 发表时间: 2022-11
• 期刊: JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
• 影响因子: 6
• 作者: Roberts, D. Allen;Bridenbecker, Daniel;Haberer, Jessica E.;Barnabas, Ruanne V.;Akullian, Adam
• 通讯作者: Akullian, Adam

A mobile health app may improve maternal and child health knowledge and practices among rural women with limited education in Uganda: a pilot randomized controlled trial.

• DOI: 10.1093/jamiaopen/ooac081
• 发表时间: 2022-12
• 期刊: JAMIA OPEN
• 影响因子: 2.1
• 作者: Musiimenta, Angella;Tumuhimbise, Wilson;Atukunda, Esther C.;Mugaba, Aaron T.;Asasira, Justus;Katusiime, Jane;Zender, Raphael;Pinkwart, Niels;Mugyenyi, Godfrey Rwambuka;Haberer, Jessica E.
• 通讯作者: Haberer, Jessica E.

Brief Report: The Impact of Disease Stage on Early Gaps in ART in the "Treatment for All" Era-A Multisite Cohort Study.

• DOI: 10.1097/qai.0000000000002605
• 发表时间: 2021-04-15
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Katz IT;Musinguzi N;Bell K;Cross A;Bwana MB;Amanyire G;Asiimwe S;Orrell C;Bangsberg DR;Haberer JE;META (Measuring Early Treatment Adherence) Team Investigators
• 通讯作者: META (Measuring Early Treatment Adherence) Team Investigators

Perceived oral health interventions by medical providers in Gugulethu, South Africa.

南非古古莱图医疗服务提供者对口腔健康干预措施的看法。

• DOI: 10.1371/journal.pone.0233437
• 发表时间: 2020
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Lambert,RFrederick;Yu,Amy;Orrell,Catherine;Haberer,JessicaE
• 通讯作者: Haberer,JessicaE