PrEP My Way: A Novel PrEP Delivery System to Meet the Needs of Young African Women
PrEP My Way: A Novel PrEP Delivery System to Meet the Needs of Young African Women
批准号:
10364655
负责人:
Jessica Elizabeth Haberer
金额:
$18.61万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-03-06 至 2024-02-29
关键词:
AIDS preventionAddressAdherenceAfrica South of the SaharaAfricanAgeBehavioral SciencesBloodBusinessesCaringCellular PhoneCharacteristicsChlamydiaClientClinicCommunicationCommunitiesContraceptive methodsDiagnostic Reagent KitsEducationEnsureEnvironmentFaceFocus GroupsFutureGeneral HospitalsGonorrheaGrantHIVHealth ServicesHomeHourHuman immunodeficiency virus testIndividualInfectionInfrastructureInterventionInterviewKenyaLocationMassachusettsMediatingMedical ResearchMethodsModelingOralPhase III Clinical TrialsPlasmaPopulationPregnancy TestsProtocols documentationQuestionnairesRandomizedResearch InstituteResearch PersonnelSamplingSelf EfficacyServicesSexual HealthSexually Transmitted DiseasesSocial BehaviorSouth AfricaSouthern AfricaSpottingsSwabSystemTechnologyTelephoneTenofovirTest ResultTestingTrainingUgandaUniversitiesVaginaVulnerable PopulationsWashingtonWomanWorkYouthZambiabasecostdesignearly experienceempowermentexperiencefemale sex workerfollow-uphealth care deliveryinnovationinterestlearning materialsmen who have sex with mennoveloral HIVpeerpeer supportpre-exposure prophylaxisprimary outcomeprogramsremote deliveryremote monitoringself testingservice uptakesocial cognitive theorysocial stigmastandard of caresuccessuptakeyoung woman
中文摘要
项目摘要-意义:撒哈拉以南非洲的年轻女性(16-24岁)是一个
英文摘要
PROJECT SUMMARY - Significance: Young women (16-24 years old) in sub-Saharan Africa are a
vulnerable population in terms of HIV acquisition with ~7,000 new infections occurring per week. Oral daily
pre-exposure prophylaxis (PrEP) is a highly effective means of HIV prevention when taken regularly. Early
experience with the global rollout of PrEP in this population indicates enthusiasm for PrEP, but also barriers to
adherence and program retention. Proposed intervention: PrEP My Way is a novel PrEP delivery system
consisting of clinic-based PrEP initiation, followed by peer-delivered kits for HIV self-testing, PrEP refills,
vaginal swabs for gonorrhea and chlamydia self-sampling, pregnancy tests, and contraception refills, if
desired. Based on Social Cognitive Theory, our overall hypothesis is that PrEP My Way will overcome critical
stigma and structural barriers that currently limit PrEP use and thus empower young women to promote their
sexual health. Innovation: This study is the first, to our knowledge, to develop a peer-delivered kit for PrEP
use, sexually transmitted infection (STI) testing, and contraception. The intervention leverages smart use of
readily available technology (e.g., SMS, WhatsApp, Vimeo) to support use of the kit and peer-based
empowerment. Approach: We will first develop, tailor, and refine PrEP My Way for use with young women in
Kisumu, Kenya (Aim 1). We will use a client-centered, iterative approach, involving ~15 individual interviews
and two focus group discussions (with ~5 women each) to optimally design the PrEP My Way kit (with
instructional materials) and peer delivery system (including communication and kit delivery plans). We will
then test the intervention for feasibility, acceptability, and preliminary impact on PrEP adherence and program
retention (Aim 2). We will randomize 100 Kenyan women to PrEP My Way versus standard of care (i.e., clinic-
based delivery of PrEP and sexual health services) and follow them for 6 months. Feasibility will be assessed
by receipt of the kit at 1, 3, and 6 months and ability to use its components per protocol. Acceptability will be
determined through a mixed-methods interview at 6 months. Preliminary impact will be evaluated by dried
blood spot tenofovir levels (adherence) and kit use/clinic attendance at 6 months (retention) as primary
outcomes. Potential influencing and mediating socio-behavioral factors will be explored with questionnaires at
baseline and 6 months. Investigators/environment: Our team has extensive relevant experience to ensure
the success of this proposal, including PrEP adherence and behavioral science (PI: Dr. Haberer at
Massachusetts General Hospital), sexual health service delivery (Dr. Bukusi at the Kenyan Medical Research
Institute, Dr. Baeten at the University of Washington), and remote delivery and monitoring for PrEP and STIs
(Dr. Siegler at Emory), as well as product design (ARK in Nairobi). Future directions: PrEP My Way is
designed with limited infrastructure needs, thus creating potential for real world implementation at scale that
can be tested in a future R01 grant.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Use of sentiment analysis in SMS and social media to understand HIV prevention needs among young women in Kenya
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批准号:10761910
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项目类别:
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资助金额:$39.51万
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财政年份:2023
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负责人:Jessica Elizabeth Haberer
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依托单位:
Research Training in Global Non-Communicable Diseases
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批准号:10554719
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项目类别:
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资助金额:$20.94万
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财政年份:2023
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负责人:Jessica Elizabeth Haberer
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依托单位:
Fostering diversity in the next generation of HIV researchers to improve the HIV continuum of care
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批准号:10653830
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项目类别:
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资助金额:$26.9万
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财政年份:2020
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负责人:Jessica Elizabeth Haberer
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依托单位:
Fostering diversity in the next generation of HIV researchers to improve the HIV continuum of care
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批准号:10228677
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项目类别:
-
资助金额:$27.06万
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财政年份:2020
-
负责人:Jessica Elizabeth Haberer
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依托单位:
Fostering diversity in the next generation of HIV researchers to improve the HIV continuum of care
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批准号:10433934
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项目类别:
-
资助金额:$26.96万
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财政年份:2020
-
负责人:Jessica Elizabeth Haberer
-
依托单位:
Fostering diversity in the next generation of HIV researchers to improve the HIV continuum of care
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批准号:10013401
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项目类别:
-
资助金额:$27.28万
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财政年份:2020
-
负责人:Jessica Elizabeth Haberer
-
依托单位:
Fostering diversity in the next generation of HIV researchers to improve the HIV continuum of care
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批准号:10790281
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项目类别:
-
资助金额:$11.64万
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财政年份:2020
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负责人:Jessica Elizabeth Haberer
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依托单位:
Optimizing mHealth for adherence monitoring and intervention
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批准号:10251996
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项目类别:
-
资助金额:$18.15万
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财政年份:2017
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负责人:Jessica Elizabeth Haberer
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依托单位:
Optimizing mHealth for adherence monitoring and intervention
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批准号:9769137
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项目类别:
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资助金额:$15.65万
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财政年份:2017
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负责人:Jessica Elizabeth Haberer
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依托单位:
Real World Adherence to HIV PrEP in Serodiscordant African Couples
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批准号:9085371
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项目类别:
-
资助金额:$59.41万
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财政年份:2013
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负责人:Jessica Elizabeth Haberer
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依托单位:
Development of Real-Time Antiretroviral Therapy Adherence Intervention in Uganda
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批准号:8666821
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项目类别:
-
资助金额:$25.96万
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财政年份:2013
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负责人:Jessica Elizabeth Haberer
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依托单位:
Real World Adherence to HIV PrEP in Serodiscordant African Couples
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批准号:9291528
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项目类别:
-
资助金额:$59.79万
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财政年份:2013
-
负责人:Jessica Elizabeth Haberer
-
依托单位:
Development of Real-Time Antiretroviral Therapy Adherence Intervention in Uganda
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批准号:8539986
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项目类别:
-
资助金额:$24.01万
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财政年份:2013
-
负责人:Jessica Elizabeth Haberer
-
依托单位:
Real World Adherence to HIV PrEP in Serodiscordant African Couples
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批准号:8670774
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项目类别:
-
资助金额:$59.17万
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财政年份:2013
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负责人:Jessica Elizabeth Haberer
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依托单位:
Real World Adherence to HIV PrEP in Serodiscordant African Couples
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批准号:8465580
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项目类别:
-
资助金额:$62.66万
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财政年份:2013
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负责人:Jessica Elizabeth Haberer
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依托单位:
Novel Measures and Theory of Pediatric Antiretroviral Therapy Adherence in Uganda
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批准号:8092574
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项目类别:
-
资助金额:$18.41万
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财政年份:2009
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负责人:Jessica Elizabeth Haberer
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依托单位:
Novel Measures and Theory of Pediatric Antiretroviral Therapy Adherence in Uganda
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批准号:8496118
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项目类别:
-
资助金额:$18.31万
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财政年份:2009
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负责人:Jessica Elizabeth Haberer
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依托单位:
Novel Measures and Theory of Pediatric Antiretroviral Therapy Adherence in Uganda
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批准号:7758048
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项目类别:
-
资助金额:$18.15万
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财政年份:2009
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负责人:Jessica Elizabeth Haberer
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依托单位:
Novel Measures and Theory of Pediatric Antiretroviral Therapy Adherence in Uganda
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批准号:7922644
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项目类别:
-
资助金额:$18.4万
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财政年份:2009
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负责人:Jessica Elizabeth Haberer
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依托单位:
Novel Measures and Theory of Pediatric Antiretroviral Therapy Adherence in Uganda
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批准号:8287644
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项目类别:
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资助金额:$18.37万
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财政年份:2009
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负责人:Jessica Elizabeth Haberer
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依托单位:
海外基金